Abstract：
:Earlier work has shown that morphine sulfate can produce a dose-related decrease in heart rate (HR) and cardiac output (CO) in isolated working rat hearts. This response is preventable with the use of the opiate receptor antagonist, naloxone hydrochloride. In this study, the stereospecificity of the opiate response was tested with the use of levorphanol tartrate and its d-isomer, dextrorphan, in our Langendorff rat heart model. The interaction of muscarinic receptor activity with the opiate response was tested by first adding bethanechol chloride to the perfusate in the presence and absence of atropine (5 X 10(-9) mmol/L). Our earlier studies with morphine sulfate were then repeated in the presence of the same concentration of atropine. At a concentration of 5 X 10(-6) mmol/L, levorphanol tartrate produced a significant decrease in CO (p less than 0.05), while a similar concentration of dextrorphan produced little change in either HR or CO. Bethanechol chloride, in a concentration of 3 X 10(-6) mmol/L, produced a significant decrease in HR and CO (p less than 0.05), which was prevented by atropine. When morphine sulfate was added to the standard perfusate (3 X 10(-4) mmol/L), HR and CO were significantly decreased (p less than 0.05). This change was not prevented by the addition of atropine. The opiate effect on myocardial function is mediated by a stereospecific opiate receptor, which acts independently of muscarinic receptor antagonism.
journal_name
Surgeryjournal_title
Surgeryauthors
Vargish T,Beamer KC,Daly T,Head Rsubject
Has Abstractpub_date
1987-08-01 00:00:00pages
171-7issue
2eissn
0039-6060issn
1532-7361pii
0039-6060(87)90231-5journal_volume
102pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:The recurrence rate for colorectal liver metastases after repeat hepatic resection is high, and selection criteria for repeat hepatectomy are still controversial. METHODS:Clinical data of patients undergoing repeat hepatectomy for metastatic colon cancer were reviewed retrospectively and compared with those...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2003.151
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:A better understanding of the analgesia needs of patients who undergo common operative procedures is necessary as we address the growing opioid public health crisis in the United States. The aim of this study was to evaluate patient experience with our opioid prescribing practice after elective inguinal hern...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.06.017
更新日期：2017-11-01 00:00:00
abstract：:A patient with an uncommon cause of portal venous hypertension, pancreatitis, is depicted. The patient had an equally uncommon pattern of symptoms and signs consisting of abdominal pain and lower gastrointestinal hemorrhage caused by colonic varices. A unique treatment, with angiographic placement of an expandable int...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:In 337 limbs (208 patients) with primary varicose veins, Doppler ultrasound was used to detect reverse flow in the saphenous veins caused by manual compression of the calf. According to the extent of reverse flow in the saphenous trunks, varicosities of the long saphenous vein were classified into five types and the s...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
abstract：BACKGROUND:Adrenal venous sampling (AVS) is used in the workup of primary hyperaldosteronism (PA). The purpose of this study was to determine the success rate of AVS and to examine the decision-making process after "less than ideal" AVS. METHODS:A total of 60 patients underwent 62 AVS for PA. Biochemical evidence of a...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2006.07.026
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Gastric cancer is an aggressive disease, and overall changes in incidence rates have been noted. There are conflicting data on whether young patients have worse outcomes than older patients; the roles of tumor biology and access to care are critical to answering this question. Our objectives were to explore ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2013.05.017
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:This study aimed to compare the radicality for and clinical advantages of laparoscopic liver resection, which is increasingly used, and the corresponding open procedure by propensity score matching analysis. METHODS:We analyzed 260 hepatocellular carcinoma patients who underwent initial liver resection at o...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.02.031
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Our aim was to examine the outcomes of patients with tertiary hyperparathyroidism (3-HPT) who had limited resection of 1 or 2 parathyroids. METHODS:We reviewed 140 patients with 3-HPT who underwent parathyroidectomy (PTX) at a single institution. Patients were analyzed according to their operation-limited P...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.09.026
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Because of controversy about the correct treatment of toxic solitary thyroid nodules, we reviewed our experience. METHODS:We retrospectively studied 32 patients (24 women and 8 men) with solitary toxic thyroid nodules who were treated at our institution (1970 to 1985). RESULTS:Median values were as follows...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：BACKGROUND:The effects of intestinal inflammation on the central nervous system are unknown. The dorsal motor nucleus of the vagus (DMNV) integrates peripheral and central signals and sends efferent signals to the gastrointestinal system. The purpose of this study was to determine the effects of intestinal inflammation...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2008.03.042
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:For the normal resolution of an acute inflammatory response, neutrophil (PMN) apoptosis is essential to maintain immune homeostasis and to limit inappropriate host tissue damage. A delay in PMN apoptosis has been implicated in the pathogenesis of the systemic inflammatory response syndrome (SIRS). Dopamine, ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
abstract：:This study compares the National Board of Medical Examiners Part II (NBME II) subtest scores of medical students attaining honors in a clinical clerkship to those of students receiving a passing score to determine if the NBME II examinations could be considered independently as valid indicators of clinical achievement...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-06-01 00:00:00
abstract：BACKGROUND:Plasma from laparotomized mice has been shown to stimulate in vitro tumor growth when compared to results with preoperative plasma. This study assessed the effect of plasma from patients who underwent major open (OS) or laparoscopic surgery (LS) on in vitro tumor cell growth. METHODS:Eighty-four patients un...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.125308
更新日期：2002-08-01 00:00:00
abstract：:Of 3,941 patients who underwent varicose vein surgery from 1968 through 1978, 163 had superficial thrombophlebitis, a common complication of varicose veins. Superficial thrombophlebitis was more frequently found in the older age groups. The incidence of occurrence (three women to one man) was identical to that of the ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-07-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to examine the mortality rate of penetrating cardiac trauma in a large urban hospital. METHODS:This was a retrospective study over a period of 5 years and 5 months of all patients admitted alive with a stab or a gunshot cardiac injury. RESULTS:There were 310 patients with a st...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：BACKGROUND:An overproduction of corticosterone during severe sepsis results in increased apoptosis of immune cells, which may result in relative immunosuppression and an impaired ability to fight infections. We have previously demonstrated that administration of tubastatin A, a selective inhibitor of histone deacetylas...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2014.03.033
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Primary tissue failure is the most frequent indication for reoperation in patients with a mitral bioprosthetic valve (MBPV). Complete excision of the bioprosthesis is time-consuming and may be complicated by cardiac rupture at the atrioventricular junction or the posterior left ventricular wall where a strut...
journal_title：Surgery
pub_type： 杂志文章,评审
doi：10.1016/s0039-6060(05)80033-9
更新日期：1995-10-01 00:00:00
abstract：BACKGROUND:The deliberate induction of carbon dioxide pneumoperitoneum during laparoscopic surgery could be a possible source of cardiovascular collapse. The effects of elevated intraabdominal pressure (IAP) on systemic hemodynamics and splanchnic blood flow created by insufflation of carbon dioxide were examined in an...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:Our purpose was to determine whether the combination of total liver vascular inflow occlusion (Pringle maneuver) and rapid hepatic transection with a clamp-crush technique results in significant reduction of blood loss and transfusion requirements during major hepatic resections. METHODS:A series of 49 adul...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1999-02-01 00:00:00
abstract：BACKGROUND:Corticosteroid use continues to rise nationally. Studies have evaluated the impact of chronic steroid use on surgical outcomes in smaller populations. This study investigated the impact of chronic steroid use on perioperative surgical outcomes in a surgical cohort of more than 5 million surgical patients, us...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2018.12.016
更新日期：2019-05-01 00:00:00
abstract：:A patient's condition was initially diagnosed as constrictive pericarditis, but an echocardiogram revealed the presence of an intracardiac tumor. The tumor was a slow-growing leiomyosarcoma that originated in the left internal iliac vein, extended into the inferior vena cava, and reached the right ventricle. This tumo...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-05-01 00:00:00
abstract：BACKGROUND:The mortality rate for abdominal vena caval injuries remains high. We examined the experience of a level I trauma center to determine factors significant to the outcome in these injuries. METHODS:Forty-seven patients were identified in a retrospective review (1989 to 1999) of patients were identified with a...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.108054
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:Benign thyroid cysts have been successfully treated with nonoperative sclerotherapy. Although OK-432 is a safe and effective sclerosing agent used to treat benign cystic lesions, little is known about its effectiveness in thyroid cysts. This study tested the efficacy of OK-432 sclerotherapy for thyroid cysts...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：10.1016/j.surg.2008.06.014
更新日期：2008-11-01 00:00:00
abstract：:Improvement of renal allograft survival by induction of immunologic unresponsiveness was attempted in 24 patients by the pretransplant administration of donor-specific whole blood or buffy coat under continuous azathioprine immunosuppression. All patients and their donors had one or two disparate HLA haplotypes. Cross...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-08-01 00:00:00
abstract：:The effect of chronic electrical stimulation on muscle mass of pedicled diaphragmatic muscle grafts (DMGs) implanted into the right ventricle was studied in 21 dogs. Nineteen dogs, followed up to 70 days (mean, 34 days), were divided into three groups. In six dogs (control) the DMG was not stimulated. In six other dog...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：BACKGROUND:The physiologic assessment of anal sphincters in cases of posttraumatic fecal incontinence is a fundamental step in planning operative treatment. In this study, we evaluate the correlation between size of anal sphincter defect, anal pressures, and clinical symptoms in patients with posttraumatic fecal incont...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.05.020
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Cytotoxic lymphocytes (CTLs) are an important component of immune function, involved in antigen recognition and resistance to viral infection. Burn injury suppresses cell-mediated immunity, induces allograft tolerance, and increases the risk of viral infection, but the mechanisms are not well understood. Thi...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(05)80354-x
更新日期：1995-08-01 00:00:00
abstract：:A new technique for endarterectomy of the aorta, iliac, femoropopliteal, and three distal vessels of the lower leg is a safe and predictable method of endarterectomy that has proved to be effective. By the use of this technique the superficial femoral artery and its collateral branches are opened, considerably increas...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-05-01 00:00:00
abstract：:The smuggling of illicit drugs by concealing them within the human body has become a widespread practice. Those individuals who transport packaged drugs are commonly known as "body packers" or "mules". "Body stuffers," on the other hand, are individuals who emergently place the contraband in a body orifice when they s...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND:Isolated limb perfusion (ILP) with melphalan is an accepted treatment for intransit melanoma of the extremities. Using an ILP human melanoma xenograft model, we tested the hypothesis that acidosis augments the antitumor effect of melphalan and that nitric oxide (NO) induction mediates tumor regression. METH...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.125713
更新日期：2002-08-01 00:00:00
