Methylphenidate hydrochloride as an antidepressant: controversy, case studies, and review.

Abstract:

:The use of psychostimulants as antidepressants remains controversial in the field of psychiatry. While methylphenidate hydrochloride (MPH) and dextroamphetamine (DA) are often considered to be equivalent drugs, differences in their neurobiologic mechanism of action may account for different clinical response patterns. Hence, clinical trials and literature reviews that examine the antidepressant efficacy of psychostimulants without distinguishing between MPH and DA may reach inaccurate conclusions. This paper is a critical review of controlled and uncontrolled studies examining the use of MPH as an antidepressant. We discuss the methodologic limitations of existing placebo-controlled trials that have reached mixed conclusions about the efficacy of MPH as an antidepressant. These studies are offset by uncontrolled open trials and clinical case reports that endorse the drug's effectiveness in alleviating depressive symptoms. The series of patients we treated with MPH demonstrates the safety and efficacy of this drug in alleviating depressive symptoms in the medically ill elderly with a variety of mood disorders. Reviewing these six cases and balancing the positive and negative reports in the literature, we provide practical guidelines for identifying patients who are potential candidates for treatment with MPH.

journal_name

South Med J

journal_title

Southern medical journal

authors

Kraus MF,Burch EA Jr

doi

10.1097/00007611-199210000-00012

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

985-91

issue

10

eissn

0038-4348

issn

1541-8243

journal_volume

85

pub_type

杂志文章,评审
  • Leukocytosis and hypercalcemia: a rare combination of paraneoplastic features in squamous cell penile cancer.

    abstract::Penile cancer is very rare in North America and Europe, as compared with the rest of the world. Squamous cell carcinoma (SCC) accounts for more than 95% of the cancer type. Paraneoplastic syndrome (PNS), a clinical syndrome of nonmetastatic systemic effects that occurs in patients with malignant disease, is often asso...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e3181d7b802

    authors: Doraiswamy VA,Biboa J,Obafemi A,Goldschmid M

    更新日期:2010-05-01 00:00:00

  • Status of the physician-patient privilege.

    abstract::While in most states information physicians obtain from the about patients is confidential and cannot be disclosed without the patient's permission, a recent California Supreme Court decision affirms that when the doctor reasonably believes his patient can cause violent harm to third persons, he had an overriding duty...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197903000-00030

    authors: Bunch PL,Dowben C

    更新日期:1979-03-01 00:00:00

  • Bilateral protrusio acetabuli in sickle cell anemia.

    abstract::Extreme bilateral protrusio acetabuli is an unusual complication of hematologic disease. We have described a patient with sickle cell anemia who had this complication probably as a result of osteopenia. Thus sickle cell anemia should be added to the list of potential causes of protrusio acetabuli. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199003000-00018

    authors: Rijke AM,Pope TL Jr,Keats TE

    更新日期:1990-03-01 00:00:00

  • Comparison of traditional and nontraditional weight loss methods: an analysis of the national health and nutrition examination survey.

    abstract:OBJECTIVES:To evaluate the real-world use of various weight loss techniques and to compare the effectiveness of nontraditional methods with diet and exercise in helping nongeriatric adults lose weight. METHODS:A cross-sectional analysis of the 2005-2010 National Health and Nutrition Examination Survey was performed. A...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.14423/SMJ.0000000000000130

    authors: Post RE,Johnson SP,Wright RU,Mainous AG 3rd

    更新日期:2014-07-01 00:00:00

  • Value of fiberoptic gastrointestinal endoscopy in infants and children.

    abstract::Fiberoptic gastrointestinal endoscopy was performed on 52 patients between the ages of 2 months and 16 years. The procedures were safely and easily done with premedications consisting of meperidine, promethazine, and chlorpromazine, and atropine, with diazepam given at the time of the procedure. Fiberoptic endoscopy w...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197805000-00022

    authors: Graham DY,Klish WJ,Ferry GD,Sabel JS

    更新日期:1978-05-01 00:00:00

  • Postoperative deaths due to unsuspected pheochromocytoma.

    abstract::Two cases of postoperative death due to unsuspected pheochromocytoma are presented. Both patients exhibited signs and symptoms preoperatively which might have been attributable to a pheochromocytoma. These reports serve as a reminder of the potentially fatal consequences of inadequate evaluation of hypertensive patien...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197711000-00023

    authors: Cross DA,Meyer JS

    更新日期:1977-11-01 00:00:00

  • Panretinal photocoagulation in the management of neovascular glaucoma.

    abstract::We report a retrospective evaluation of the role of panretinal photocoagulation in the primary treatment of neovascular glaucoma. Thirty-six eyes (32 patients) received aggressive argon laser panretinal photocoagulation beginning as soon as feasible after diagnosis of the developing neovascular glaucoma. Thirty eyes w...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198811000-00008

    authors: Cashwell LF,Marks WP

    更新日期:1988-11-01 00:00:00

  • Primary squamous cell carcinoma of the breast.

    abstract::Primary squamous cell carcinoma of the breast is a rare cancer. Published reports of prognosis are variable, and most studies are case reports of one or a few patients. We report an additional case of squamous cell carcinoma of the breast occurring in a 53-year-old black woman. In reviewing the reported cases of this ...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/00007611-199605000-00013

    authors: Weigel RJ,Ikeda DM,Nowels KW

    更新日期:1996-05-01 00:00:00

  • Mycobacterium fortuitum Meningitis: Approach to Lumboperitoneal Shunt Infection.

    abstract::Mycobacterium fortuitum is a rare, opportunistic pathogen most frequently contracted through contact with a contaminated source. An immunocompetent 26-year-old female patient presented to our institution with an infected lumboperitoneal (LP) shunt presenting as continued nonhealing wounds. After multiple debridements,...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.14423/SMJ.0000000000000955

    authors: Zakrzewski J,Hu K,Neisewander BL,Esfahani DR,Bhimani AD,Shah HP,Haddadin DW,Mehta AI

    更新日期:2019-04-01 00:00:00

  • M-mode echocardiographic abnormalities in Rocky Mountain spotted fever.

    abstract::Rocky Mountain spotted fever is a serious acute systemic illness frequently complicated by cardiac involvement. To evaluate the spectrum of myocardial dysfunction, we obtained M-mode echocardiograms on nine consecutive patients with Rocky Mountain spotted fever within 72 hours of admission. Seven of the nine patients ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198409000-00019

    authors: Feltes TF,Wilcox WD,Feldman WE,Lipskis DJ,Carter SL,Bugg GW

    更新日期:1984-09-01 00:00:00

  • Use of Cardiac Troponin Testing in the Outpatient Setting.

    abstract:OBJECTIVES:Cardiac troponin (cTn) measurement is useful for diagnosing myocardial infarction (MI), particularly in the inpatient setting. A growing body of literature suggests that cTn may be useful for evaluating chronic conditions in the outpatient environment; however, little is known regarding cTn ordering patterns...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.14423/SMJ.0000000000000971

    authors: Ross SJ,Shah NH,Noutong Njapo SA,Cordiner DJ,Winchester DE

    更新日期:2019-05-01 00:00:00

  • Mediastinal tumors and pseudotumors: evaluation by computerized tomography.

    abstract::In this series, thorough evaluation of 250 mediastinal lesions by various diagnostic methods showed that contrast enhanced CT scans of the mediastinum were superior to other modalities in differentiation and precise localization of the various types of lesions. Such superior evaluation may have a profound effect on th...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198504000-00009

    authors: Devkota J

    更新日期:1985-04-01 00:00:00

  • Sports Concussion Management: part II.

    abstract::Millions of concussions occur every year in the United States. The public interest in concussion has increased after a number of high-profile deaths in high school athletes from sports-related head trauma and in some professional athletes from chronic traumatic encephalopathy. One of the most active areas of research ...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/SMJ.0000000000000064

    authors: Terrell TR,Cox CB,Bielak K,Casmus R,Laskowitz D,Nichols G

    更新日期:2014-02-01 00:00:00

  • Cimetidine usage for unlabeled conditions in an ambulatory care service.

    abstract::With the intent of cost containment, we conducted a survey of cimetidine usage in the Ambulatory Care Service of our Veterans Administration Medical Center. During a period of six months, this drug was prescribed for 132 patients. Only about 20% received cimetidine for FDA approved conditions. Treated conditions not a...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198410000-00019

    authors: Thomas CT,Thomas E,Reddy KR,Martin E,Stapleton JA

    更新日期:1984-10-01 00:00:00

  • Retrocardiac densities due to paraesophageal varices: roentgenographic detection.

    abstract::We have described a patient with portal hypertension and retrocardiac paramediastinal density on upright PA chest x-ray film. Splenoportograms showed this density to be paraesophageal collateral veins. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198511000-00030

    authors: Frederick HM,Clements JL Jr,Colvin RS

    更新日期:1985-11-01 00:00:00

  • Metamorphosis of breast cancer.

    abstract::In two decades there has been a sweeping metamorphosis of the antiquated conception of breast cancer as a solitary mass of questionable operability, accompanied by numerous axillary lymph nodes and probably distant metastasis. An undreamed-of recognizable preclinical stage of breast cancer has drastically changed atti...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197811000-00004

    authors: Egan RL

    更新日期:1978-11-01 00:00:00

  • Orthopedic surgery postgraduate year 1 intern curriculum improves initial orthopedic in-training examination performance.

    abstract:OBJECTIVE:To determine the efficacy of an educational curriculum designed for orthopedic surgery postgraduate year 1 (PGY-1) interns to improve initial Orthopedic In-Training Examination (OITE) performance. METHODS:A retrospective cohort study was performed that evaluated the PGY-1 intern OITE performance of one resid...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e31824fb9a4

    authors: Roberts CS,Nyland J,Broome B

    更新日期:2012-04-01 00:00:00

  • A unique case of recurrent takotsubo cardiomyopathy.

    abstract::Takotsubo (stress induced) cardiomyopathy is also known as broken heart syndrome or transient left ventricular apical ballooning syndrome. The clinical presentation, which mimics acute myocardial infarction, is preceded by intense emotional or physical stress. Recurrence of apical ballooning syndrome seems to be rare....

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e3181e631ce

    authors: Pathak H,Esses J,Pathak S,Frankel R,Hollander G

    更新日期:2010-08-01 00:00:00

  • Role of Rifaximin in Spontaneous Bacterial Peritonitis Prevention.

    abstract::Cirrhosis affects millions of people around the world and is associated with increased morbidity and mortality. Spontaneous bacterial peritonitis (SBP) is a common complication of liver disease with cirrhosis and accounts for up to 30% of infections in patients with cirrhosis. Patients with a history of SBP and those ...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.14423/SMJ.0000000000000887

    authors: Oliver A,Wong M,Sanchez C

    更新日期:2018-11-01 00:00:00

  • Thoracoabdominal radiculopathy.

    abstract::Thoracic nerve root dysfunction (TNRD) manifested as abdominal pain is an infrequently reported condition. We present data on six patients who had chronic intermittent thoracoabdominal pain originating in the back. Diabetes and osteoarthritis of the spine were the chief causes of these symptoms. The electromyogram in ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198802000-00014

    authors: Sellman MS,Mayer RF

    更新日期:1988-02-01 00:00:00

  • Massive edema of the ovary associated with androgenic manifestations.

    abstract::Massive ovarian edema is a rare tumor-like condition of the ovary characterized by marked enlargement of one or both ovaries due to marked accumulation of edema fluid in the ovarian stroma. This paper reviews the literature on massive ovarian edema and presents a case associated with androgenic manifestations. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/00007611-199511000-00015

    authors: Siller BS,Gelder MS,Alvarez RD,Partridge EE

    更新日期:1995-11-01 00:00:00

  • Comorbidity of schizophreniform disorder and borderline personality disorder in an 18-year-old black woman.

    abstract::We describe a rare occurrence of comorbidity of schizophreniform disorder and borderline personality disorder as an initial patient presentation. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199803000-00013

    authors: Houry D,Johnson J,Cabrejos C

    更新日期:1998-03-01 00:00:00

  • Tuberculous peritonitis: fatality associated with delayed diagnosis.

    abstract::We describe a fatal case of tuberculous peritonitis and review the literature on the diagnostic modalities available to diagnose this entity. We suspect a delayed diagnosis resulted in the death of our patient. Today, the prompt diagnosis of an unknown ascitic process involves laparoscopy. A patient with unknown large...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/00007611-199904000-00010

    authors: Ahmad M,Ahmed A

    更新日期:1999-04-01 00:00:00

  • Exercise and the aging foot.

    abstract::Overall physical fitness has become increasingly popular in the 1990s, especially in the geriatric community. More runners, bikers, swimmers, and aerobic advocates over the age of 55 are requiring medical attention for foot complaints, as the feet are a necessary tool for almost any athletic activity. This paper discu...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:

    authors: Gordon GM,Cuttic MM

    更新日期:1994-05-01 00:00:00

  • The development, status, and future of healthcare chaplaincy.

    abstract::This review article provides insight into the evolution of professional healthcare chaplaincy. It identifies key historical developments identifying the training, qualifications, and competencies of chaplains. Consideration is given to both the unique character of the pastoral role in healthcare as well as the contrib...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/01.smj.0000220893.37354.1e

    authors: Ford T,Tartaglia A

    更新日期:2006-06-01 00:00:00

  • Pseudoepitheliomatous hyperplasia mistaken for cancer after delayed reconstruction.

    abstract::Pseudoepitheliomatous hyperplasia (PEH) arises in areas of chronic inflammation and can be mistaken for squamous cell carcinoma, leading to unnecessary removal of more tissue. We present a study of 21 patients having delayed reconstruction of defects left by Mohs micrographic surgery (MMS) to remove facial skin cancer...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199504000-00014

    authors: Calhoun KH,Wagner RF Jr,Kumar D,Hokanson JA

    更新日期:1995-04-01 00:00:00

  • Neuroleptospirosis with hydrocephalus and very elevated cerebrospinal fluid protein.

    abstract::To our knowledge, this is the first known case of a patient with leptospirosis and very elevated CSF, which caused hydrocephalus. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e3181a0ae80

    authors: Sakellaridis N,Panagopoulos D,Androulis A

    更新日期:2009-05-01 00:00:00

  • Risk Factors for 30-Day Readmissions of Individuals with Decompensated Cirrhosis.

    abstract:OBJECTIVES:Patients with cirrhosis have a high rate of 30-day hospital readmission that affects their quality of life and contributes to increased healthcare-related costs. The aim of our study was to identify frequency, predictors, and preventable causes of hospital readmissions among patients with decompensated cirrh...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.14423/SMJ.0000000000000371

    authors: Agrawal K,Kumar P,Markert R,Agrawal S

    更新日期:2015-11-01 00:00:00

  • Risk assessment and management of anthracycline and HER2 receptor inhibitor-induced cardiomyopathy.

    abstract::With the advent and increased use of chemotherapeutic agents and radiation therapy, cancer survival rates have increased. With increased survival, both acute and chronic cardiotoxic adverse effects have emerged. The growing need for managing the treatment of individuals with chemotherapy-induced cardiotoxicity has led...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.14423/SMJ.0000000000000232

    authors: Jahangir E,Shah S,Shum K,Baxter C,Fitzpatrick JD,Cole J,Gilliland Y,Polin NM

    更新日期:2015-02-01 00:00:00

  • Carbenicillin nephrotoxicity.

    abstract::A patient with biopsy-proven interstitial nephritis associated with nafcillin and dicloxacillin therapy developed fever, hematuria, pyuria, and renal insufficiency after the administration of carbenicilin five months later. Cephalosporin therapy was given to this patient without signs of renal toxicity. This is the fi...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197801000-00028

    authors: Roselle GA,Clyne DH,Kauffman CA

    更新日期:1978-01-01 00:00:00