Is gastric metaplasia essential for duodenal ulcer?

Abstract:

:Multiple biopsies were taken from the duodenum of 100 patients (46 active duodenal ulcer, 14 healed duodenal ulcer, 40 control subjects) to detect duodenitis, gastric metaplasia and Helicobacter pylori (Hp). Histamine-induced congo-red staining of the duodenal bulb was performed in additional 25 cases of active duodenal ulcer to determine the presence of functioning parietal cells in the duodenum. The incidence of duodenitis was 45% in control subjects and 76.7% in patients with duodenal ulcer (active or healed) (p < 0.01). Superficial gastric metaplasia was present in 2.5% of control subjects and 13.3% patients with duodenal ulcer (active or healed) (p > 0.05). Hp in the duodenum was detected in 10% of control subjects and 8.3% of patients with duodenal ulcer. Congo-red test was positive in two of 25 (8%) patients of active duodenal ulcer indicating "functioning" parietal cells in the duodenum. In Indian patients with duodenal ulcer, a low incidence of gastric metaplasia and Hp in the duodenum is observed in contrast to its high incidence in patients from Western countries.

journal_name

J Clin Gastroenterol

authors

Amarapurkar DN,Parikh SS,Prabhu SR,Kalro RH,Desai HG

doi

10.1097/00004836-199310000-00007

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

204-6

issue

3

eissn

0192-0790

issn

1539-2031

journal_volume

17

pub_type

杂志文章
  • Autoimmune pancreatitis, pancreatic mass, and lower gastrointestinal bleed.

    abstract::Autoimmune pancreatitis (AIMP) is a recently described clinical entity causing chronic pancreatitis. It often presents with diffuse enlargement of the pancreas and/or a focal mass at the head of the pancreas causing common bile duct obstruction and jaundice. In most instances, AIMP is mistaken for pancreatic cancer. A...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199906000-00019

    authors: Venu RP,Radke JS,Brown RD,Deutsch SF,Zaytsev PM,Miyaji E,Nishimori I

    更新日期:1999-06-01 00:00:00

  • Therapy of NAFLD: insulin sensitizing agents.

    abstract::Insulin resistance is an integral part of the underlying pathophysiology in most patients with nonalcoholic fatty liver disease (NAFLD). Insulin-sensitizing agents are therefore likely to be of key importance in the treatment of this disorder, especially in the histologically more severe form known as nonalcoholic ste...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcg.0000168647.71411.48

    authors: Caldwell SH,Argo CK,Al-Osaimi AM

    更新日期:2006-03-01 00:00:00

  • Prophylactic placement of gastrostomy feeding tubes before radiotherapy in patients with head and neck cancer: is it worthwhile?

    abstract:BACKGROUND:After radiation treatment of head and neck cancer, placement of gastrostomy feeding tubes can be technically difficult. The practice of placing tubes before treatment is probably justified if the tube is used for more than 4 weeks and if complications are infrequent. The aim of this study was to determine th...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200109000-00009

    authors: Scolapio JS,Spangler PR,Romano MM,McLaughlin MP,Salassa JR

    更新日期:2001-09-01 00:00:00

  • An update on clinical trials in the treatment of advanced hepatocellular carcinoma.

    abstract::Despite the successful FDA approval of sorafenib as the standard of care therapy in patients with advanced hepatocellular carcinoma (HCC), its clinical benefits have been modest. The mortality rate remains high and prognosis poor for patients with advanced-stage HCC. The exact mechanism of sorafenib in the treatment o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31827d77a2

    authors: Lee JK,Abou-Alfa GK

    更新日期:2013-07-01 00:00:00

  • Perforation of small intestine caused by Churg-Strauss syndrome.

    abstract::In Churug-Strauss Syndrome (CSS), gastrointestinal tract (GIT) is an uncommon site of involvement. In addition to review of recent literature, we herein report a case of CSS with unusual involvement of GIT. The patient was being treated for idiopathic hypereosinophilic syndrome for 2 years; he later developed acute pe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199610000-00017

    authors: Sharma MC,Safaya R,Sidhu BS

    更新日期:1996-10-01 00:00:00

  • Screening colonoscopy use among individuals at higher colorectal cancer risk.

    abstract:GOALS:To describe screening colonoscopy use in those with a family history of colorectal cancer (CRC). BACKGROUND:Colonoscopy is an effective means of screening for CRC and is preferred for individuals at higher risk. We therefore derived population-based estimates of colonoscopy use and analyzed how individual charac...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200607000-00006

    authors: Longacre AV,Cramer LD,Gross CP

    更新日期:2006-07-01 00:00:00

  • Is smoking still important in the pathogenesis of peptic ulcer disease?

    abstract::The pathogenesis of peptic ulcer disease is multifactorial, including the effects of Helicobacter pylori, gastric acid, pepsin, gastroduodenal motility, smoking and nicotine, and the complex interaction of an array of other so-called aggressive and protective factors. Since the discovery and acceptance of H. pylori as...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199700001-00003

    authors: Eastwood GL

    更新日期:1997-01-01 00:00:00

  • Current Management of Patients With Diverticulosis and Diverticular Disease: A Survey From the 2nd International Symposium on Diverticular Disease.

    abstract:BACKGROUND:Management of diverticular disease (DD) remains a point of debate. GOALS:To investigate the current opinion of participants of the 2nd International Symposium on Diverticular Disease, on real-life management of patients with DD of the colon. STUDY:Twelve questions were aimed at the diagnosis, treatment, an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000645

    authors: Tursi A,Picchio M,Elisei W,Di Mario F,Scarpignato C,Brandimarte G

    更新日期:2016-10-01 00:00:00

  • Fatal reactivation of hepatitis B virus in a patient who was hepatitis B surface antigen negative and core antibody positive before receiving chemotherapy for non-Hodgkin lymphoma.

    abstract::Patients who are hepatitis B surface antigen (HBsAg) positive are at risk for hepatitis flare when receiving cytotoxic or immunosuppressive therapy. It has been reported that as high as 50% of HBsAg-positive individuals who undergo chemotherapy develop elevation of liver transaminases. According to current Association...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181945942

    authors: Wu JM,Huang YH,Lee PC,Lin HC,Lee SD

    更新日期:2009-05-01 00:00:00

  • Effect of calcitonin on gastric emptying and on serum insulin and gastrin concentrations after ingestion of a mixed solid-liquid meal in humans.

    abstract::In a double-blind placebo-controlled study, we examined the effect of calcitonin on gastric emptying, and on serum concentrations of gastrin, insulin, glucose, calcium, and phosphorus after a mixed solid-liquid meal in 11 healthy men. Synthetic salmon calcitonin was administered as a 415 pmol i.v. bolus injection foll...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-199002000-00007

    authors: Jonderko K,Jonderko G,Gołab T

    更新日期:1990-02-01 00:00:00

  • Alpha-fetoprotein-producing clear cell carcinoma of the extrahepatic bile ducts.

    abstract::A 79-year-old woman visiting our hospital with chief complaints of epigastric pain and jaundice was emergently admitted. Her alpha-fetoprotein (AFP) level was as high as 2265 ng/mL at admission. Her abdominal computed tomography scan revealed dilation of the intrahepatic bile duct and a tumorlike lesion protruding int...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200607000-00016

    authors: Miyazawa M,Torii T,Toshimitsu Y,Kamizasa N,Suzuki T,Shinozuka N,Ishizawa K,Koyama I

    更新日期:2006-07-01 00:00:00

  • Serum hepatitis C virus titers in the progression of type C chronic liver disease. With special emphasis on patients with type 1b infection.

    abstract::The correlation of serum hepatitis C virus (HCV) titers to the progression of type C chronic liver disease remains controversial. We have investigated the relationship between serum HCV titers and different histological stages of chronic liver disease, including chronic persistent hepatitis (CPH), chronic active hepat...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004836-199612000-00008

    authors: Kao JH,Lai MY,Chen PJ,Hwang LH,Chen DS

    更新日期:1996-12-01 00:00:00

  • Efficacy of sucralfate in the prevention of recurrence of duodenal ulcers.

    abstract::Eighty-four patients who were endoscopically confirmed to have healed duodenal ulcers were entered into this 1-year, double-blind, placebo-controlled trial of sucralfate, 1g twice daily, in the prevention of duodenal ulcer recurrence. Patients remained in the study until recurrence of ulceration was endoscopically con...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-198709011-00006

    authors: Behar J,Roufail W,Thomas E,Keller F,Dernbach W,Tesler MA

    更新日期:1987-01-01 00:00:00

  • Primary biliary cirrhosis and chronic pancreatitis in a patient with ulcerative colitis.

    abstract::A 65-year-old Japanese woman had primary biliary cirrhosis (PBC) and chronic pancreatitis associated with ulcerative colitis. The association of PBC and ulcerative colitis may prove to be valid. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198510000-00011

    authors: Kato Y,Morimoto H,Unoura M,Kobayashi K,Hattori N,Nakanuma Y

    更新日期:1985-10-01 00:00:00

  • The differential diagnosis of eosinophilic esophagitis.

    abstract::Eosinophilic esophagitis is a morphologic finding that may result from a wide spectrum of clinical conditions. The distinctive histological features accompanying eosinophilic esophagitis may facilitate the diagnosis of the underlying disease entity. Unfortunately, there are no pathognomonic histologic characteristics ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200004000-00007

    authors: Ahmad M,Soetikno RM,Ahmed A

    更新日期:2000-04-01 00:00:00

  • Predictive factors for metachronous recurrence of early gastric cancer after endoscopic treatment.

    abstract::Since endoscopic treatment has been evaluated and become established as treatment for early gastric cancer, metachronous recurrence has become a major problem. In this report, predictive factors for recurrence were studied using the Kaplan-Meier method and Cox's proportional hazards regression model in 76 patients who...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199907000-00011

    authors: Arima N,Adachi K,Katsube T,Amano K,Ishihara S,Watanabe M,Kinoshita Y

    更新日期:1999-07-01 00:00:00

  • Endoscopic ultrasonography in multiple lymphomatous polyposis.

    abstract::Two cases of multiple lymphomatous polyposis (MLP) are presented, involving different segments of the gastrointestinal tract. Both cases display the characteristic clinical and pathologic features of MLP. In addition, we were able to document, for the first time, the endoscopic ultrasonographic findings in this diseas...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200202000-00010

    authors: Viana HL,Henrique RM,Ferreira ES,Correia AM,Silva RA,Dias LM,Viana RL

    更新日期:2002-02-01 00:00:00

  • Colonic variceal hemorrhage: diagnosis and management.

    abstract::Lower gastrointestinal bleeding colonic varices is infrequent. We report a patient in whom the diagnosis was made by angiography and in whom portosystemic shunt has been helpful. We believe that the treatment of choice for colonic varices is portosystemic shunt, as attempts at resection, judged by the reports in the l...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198502000-00011

    authors: Katz LB,Shakeed A,Messer J

    更新日期:1985-02-01 00:00:00

  • Hepatoblastoma presenting as isosexual precocity. The clinical importance of histologic and serologic parameters.

    abstract::A 2-year-old boy presented with sexual precocity secondary to a hormone-producing hepatoblastoma. The tumor demonstrated an aggressive histologic pattern and stained immunohistochemically for alpha-fetoprotein and beta-subunit human chorionic gonadotrophin. After a successful liver transplant these tumor markers were ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Heimann A,White PF,Riely CA,Ritchey AK,Flye MW,Barwick KW

    更新日期:1987-02-01 00:00:00

  • Effects of growth factors on acid-induced damage to rat gastric epithelial cells.

    abstract::We previously established a model of cell damage induced by an acidified medium in the rat gastric epithelial cell line RGM1. Treatment of the cells with epidermal growth factor (EGF, 1-10 ng/ml) for 4 h prevented acid-induced cell damage in a concentration-dependent manner. In contrast, basic fibroblast growth factor...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199700001-00013

    authors: Furukawa O,Okabe S

    更新日期:1997-01-01 00:00:00

  • Clinical features of patients with negative results from traditional diagnostic work-up and Crohn's disease findings from capsule endoscopy.

    abstract:INTRODUCTION:Capsule endoscopy (CE) can detect Crohn's disease in patients with suggestive symptoms but with negative results from the traditional diagnostic work-up (ileocolonoscopy and small bowel follow-through). The objective of this study was to determine which clinical features predict the diagnosis of Crohn's di...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200609000-00006

    authors: Valle J,Alcántara M,Pérez-Grueso MJ,Navajas J,Muñoz-Rosas C,Legaz ML,Cuena R,Carrobles JM

    更新日期:2006-09-01 00:00:00

  • The symptomatic and histologic response to a gluten-free diet in patients with borderline enteropathy.

    abstract:GOALS:A clinical problem is posed by patients with symptoms suggestive of gluten sensitivity (diarrhea, weight loss, unresponsive iron-deficiency anemia, etc.); however, small intestinal biopsies reveal only minor abnormalities, such as lymphocytosis with or without crypt hyperplasia (Marsh I-II). Our aim was to assess...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200301000-00006

    authors: Tursi A,Brandimarte G

    更新日期:2003-01-01 00:00:00

  • Patient outcomes related to percutaneous endoscopic gastrostomy placement.

    abstract::Although many aspects of percutaneous endoscopic gastrostomy (PEG) have been addressed in the literature, attention to psychologic and social outcomes of PEG has been limited. Our goal was to assess a range of physical, psychologic, and social outcomes related to PEG feeding. This study is a follow-up survey of patien...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200101000-00012

    authors: Verhoef MJ,Van Rosendaal GM

    更新日期:2001-01-01 00:00:00

  • A randomized, controlled trial of interactive, multimedia software for patient colonoscopy education.

    abstract::The purpose of our study was to assess the effectiveness of computer-assisted instruction (CAI) in patients having colonoscopies. We conducted a randomized, controlled trial in large, multispecialty clinic. Eighty-six patients were referred for colonoscopies. The interventions were standard education versus standard e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-200102000-00010

    authors: Shaw MJ,Beebe TJ,Tomshine PA,Adlis SA,Cass OW

    更新日期:2001-02-01 00:00:00

  • Oxides, onions, and other matters gastrointestinal--1996--a perspective.

    abstract::A selection of landmark articles for a given year in any subject risks being somewhat subjective, and subjectivity is best avoided in scientific endeavor. However, the very nature of such a selection process invites judgment. Like most judges, I, too, claim to avoid conscious bias, but no one who has ever graced the b...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199704000-00003

    authors: Kapadia CR

    更新日期:1997-04-01 00:00:00

  • Percutaneous endoscopic gastrostomy sites infected by methicillin-resistant Staphylococcus aureus: impact on outcome.

    abstract:BACKGROUND:The impact of methicillin-resistant Staphylococcus aureus (MRSA) colonization of percutaneous endoscopic gastrostomy (PEG) sites on morbidity and mortality is uncertain. AIM:We investigated the impact of known prior MRSA colonization on the incidence of symptomatic PEG site wound infection and mortality. M...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000210096.44123.b6

    authors: Mainie I,Loughrey A,Watson J,Tham TC

    更新日期:2006-04-01 00:00:00

  • A comprehensive review of eosinophilic esophagitis in adults.

    abstract::Eosinophilic esophagitis is a recently described disease characterized by the presence of upper gastrointestinal tract symptoms in association with a dense esophageal eosinophilic infiltrate. The awareness and interest of physicians and researchers in this disease has been increasing as reflected by the number of publ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e318211f95b

    authors: Almansa C,Devault KR,Achem SR

    更新日期:2011-09-01 00:00:00

  • Unilateral Versus Bilateral Lung Transplantation: Do Different Esophageal Risk Factors Predict Chronic Allograft Failure?

    abstract:GOALS:To assess the effect of unilateral versus bilateral lung transplantation (LTx) on esophageal motility and gastroesophageal reflux, and the association with the development of obstructive chronic lung allograft dysfunction (o-CLAD). BACKGROUND:We have shown that esophagogastric junction outflow obstruction, incom...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001015

    authors: Tangaroonsanti A,Lee AS,Vela MF,Crowell MD,Erasmus D,Keller C,Mallea J,Alvarez F,Almansa C,DeVault KR,Houghton LA

    更新日期:2019-04-01 00:00:00

  • The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations.

    abstract::Aspirin is commonly accepted as a risk factor for gastric ulcer; however, there is little published evidence linking aspirin consumption to duodenal ulcer. The effect of 1 g of aspirin per day on site-specific ulcer hospitalizations was examined using data from a 3-year randomized, double-blind, placebo-controlled tri...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-199006000-00005

    authors: Kurata JH,Abbey DE

    更新日期:1990-06-01 00:00:00

  • Diagnostic yield of spiral enteroscopy when performed for the evaluation of abnormal capsule endoscopy findings.

    abstract:BACKGROUND:Spiral enteroscopy (SE) has emerged as a new alternative for deep intubation of the small intestine. SE is most often used to evaluate abnormal findings on capsule endoscopy (CE). OBJECTIVE:Investigate the ability of SE to reproduce abnormal findings detected on preceding CE. DESIGN:Prospective study. SET...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181eeb74b

    authors: Buscaglia JM,Richards R,Wilkinson MN,Judah JR,Lam Y,Nagula S,Draganov PV

    更新日期:2011-04-01 00:00:00