Abstract:
:In this paper, a new and efficient method for synthesis of phloroglucinol with an overall yield of 60% was described. As well, the phloroglucinol association on an immobilized human serum albumin (HSA) column was analyzed in biochromatography by the determination of its Langmuir distribution isotherms. The role of the magnesium cation Mg2+ on the phloroglucinol-HSA binding process was as well analyzed. The results showed that in the Mg2+ concentration range (0.7-2 mM) (including its biological concentration range, i.e. 0.75-0.90 mM), increasing the Mg2+ concentration increased the fraction of free phloroglucinol (not linked with HSA) and thus its biological effect.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Ismaili L,Refouvelet B,Xicluna A,Robert JF,Guillaume YCdoi
10.1016/s0731-7085(03)00220-6subject
Has Abstractpub_date
2003-07-14 00:00:00pages
549-53issue
3eissn
0731-7085issn
1873-264Xpii
S0731708503002206journal_volume
32pub_type
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