Regression dilution in the proportional hazards model.

Abstract:

:The problem of regression dilution arising from covariate measurement error is investigated for survival data using the proportional hazards model. The naive approach to parameter estimation is considered whereby observed covariate values are used, inappropriately, in the usual analysis instead of the underlying covariate values. A relationship between the estimated parameter in large samples and the true parameter is obtained showing that the bias does not depend on the form of the baseline hazard function when the errors are normally distributed. With high censorship, adjustment of the naive estimate by the factor 1 + lambda, where lambda is the ratio of within-person variability about an underlying mean level to the variability of these levels in the population sampled, removes the bias. As censorship increases, the adjustment required increases and when there is no censorship is markedly higher than 1 + lambda and depends also on the true risk relationship.

journal_name

Biometrics

journal_title

Biometrics

authors

Hughes MD

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

1056-66

issue

4

eissn

0006-341X

issn

1541-0420

journal_volume

49

pub_type

杂志文章
  • A biological marker model for predicting disease transitions.

    abstract::For patients with chronic myelogenous leukemia (CML), the effect of elevated blood levels of adenosine deaminase (ADA) is studied as a marker for transitions from stable disease to blast crisis and then to death. Data in the form of snapshots over time, with day, state of disease, and ADA level, are analyzed for 55 pa...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:

    authors: Klein JP,Klotz JH,Grever MR

    更新日期:1984-12-01 00:00:00

  • Semiparametric estimation of the covariate-specific ROC curve in presence of ignorable verification bias.

    abstract::Covariate-specific receiver operating characteristic (ROC) curves are often used to evaluate the classification accuracy of a medical diagnostic test or a biomarker, when the accuracy of the test is associated with certain covariates. In many large-scale screening tests, the gold standard is subject to missingness due...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.1541-0420.2011.01562.x

    authors: Liu D,Zhou XH

    更新日期:2011-09-01 00:00:00

  • Nonparametric discrete survival function estimation with uncertain endpoints using an internal validation subsample.

    abstract::When a true survival endpoint cannot be assessed for some subjects, an alternative endpoint that measures the true endpoint with error may be collected, which often occurs when obtaining the true endpoint is too invasive or costly. We develop an estimated likelihood function for the situation where we have both uncert...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/biom.12316

    authors: Zee J,Xie SX

    更新日期:2015-09-01 00:00:00

  • Combining band recovery data and Pollock's robust design to model temporary and permanent emigration.

    abstract::Capture-recapture models are widely used to estimate demographic parameters of marked populations. Recently, this statistical theory has been extended to modeling dispersal of open populations. Multistate models can be used to estimate movement probabilities among subdivided populations if multiple sites are sampled. ...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.0006-341x.2001.00273.x

    authors: Lindberg MS,Kendall WL,Hines JE,Anderson MG

    更新日期:2001-03-01 00:00:00

  • A semiparametric estimate of treatment effects with censored data.

    abstract::A semiparametric estimate of an average regression effect with right-censored failure time data has recently been proposed under the Cox-type model where the regression effect beta(t) is allowed to vary with time. In this article, we derive a simple algebraic relationship between this average regression effect and a m...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.0006-341x.2001.00875.x

    authors: Xu R,Harrington DP

    更新日期:2001-09-01 00:00:00

  • Comment on "Wang et al. (2005), Robust estimating functions and bias correction for longitudinal data analysis".

    abstract::This note provides a discussion on the manuscript by Wang et al. (2005) who aim to robustify inference for longitudinal data analysis by replacing the ordinary generalized estimating function with an influence-bounded, possibly biased, version. To adjust for the bias of the ensuing robust estimator, the authors provid...

    journal_title:Biometrics

    pub_type: 信件

    doi:10.1111/biom.13263

    authors: Lunardon N,Menardi G

    更新日期:2020-09-01 00:00:00

  • Optimal Bayesian design for patient selection in a clinical study.

    abstract::Bayesian experimental design for a clinical trial involves specifying a utility function that models the purpose of the trial, in this case the selection of patients for a diagnostic test. The best sample of patients is selected by maximizing expected utility. This optimization task poses difficulties due to a high-di...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.1541-0420.2008.01156.x

    authors: Buzoianu M,Kadane JB

    更新日期:2009-09-01 00:00:00

  • Bayesian enrichment strategies for randomized discontinuation trials.

    abstract::We propose optimal choice of the design parameters for random discontinuation designs (RDD) using a Bayesian decision-theoretic approach. We consider applications of RDDs to oncology phase II studies evaluating activity of cytostatic agents. The design consists of two stages. The preliminary open-label stage treats al...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.1541-0420.2011.01623.x

    authors: Trippa L,Rosner GL,Müller P

    更新日期:2012-03-01 00:00:00

  • Ultra high-dimensional semiparametric longitudinal data analysis.

    abstract::As ultra high-dimensional longitudinal data are becoming ever more apparent in fields such as public health and bioinformatics, developing flexible methods with a sparse model is of high interest. In this setting, the dimension of the covariates can potentially grow exponentially as ...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/biom.13348

    authors: Green B,Lian H,Yu Y,Zu T

    更新日期:2020-08-04 00:00:00

  • Breeding return times and abundance in capture-recapture models.

    abstract::For many long-lived animal species, individuals do not breed every year, and are often not accessible during non-breeding periods. Individuals exhibit site fidelity if they return to the same breeding colony or spawning ground when they breed. If capture and recapture is only possible at the breeding site, temporary e...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/biom.12094

    authors: Pledger S,Baker E,Scribner K

    更新日期:2013-12-01 00:00:00

  • Selecting factors predictive of heterogeneity in multivariate event time data.

    abstract::In multivariate survival analysis, investigators are often interested in testing for heterogeneity among clusters, both overall and within specific classes. We represent different hypotheses about the heterogeneity structure using a sequence of gamma frailty models, ranging from a null model with no random effects to ...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.0006-341X.2004.00179.x

    authors: Dunson DB,Chen Z

    更新日期:2004-06-01 00:00:00

  • Statistical methods in ophthalmology: an adjusted chi-square approach.

    abstract::Ophthalmologic studies often compare several groups of subjects for the presence or absence of some ocular finding, where each subject may contribute two eyes to the analysis, the values from the two eyes being highly correlated. Rosner (1982, Biometrics 38, 105-114) and Dallal (1988, Biometrics 44, 253-257) proposed ...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:

    authors: Donner A

    更新日期:1989-06-01 00:00:00

  • Sample size determination for establishing equivalence/noninferiority via ratio of two proportions in matched-pair design.

    abstract::In this article, we propose approximate sample size formulas for establishing equivalence or noninferiority of two treatments in match-pairs design. Using the ratio of two proportions as the equivalence measure, we derive sample size formulas based on a score statistic for two types of analyses: hypothesis testing and...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.0006-341x.2002.00957.x

    authors: Tang ML,Tang NS,Chan IS,Chan BP

    更新日期:2002-12-01 00:00:00

  • Sensitivity analysis for nonrandom dropout: a local influence approach.

    abstract::Diggle and Kenward (1994, Applied Statistics 43, 49-93) proposed a selection model for continuous longitudinal data subject to nonrandom dropout. It has provoked a large debate about the role for such models. The original enthusiasm was followed by skepticism about the strong but untestable assumptions on which this t...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.0006-341x.2001.00007.x

    authors: Verbeke G,Molenberghs G,Thijs H,Lesaffre E,Kenward MG

    更新日期:2001-03-01 00:00:00

  • The estimation of maternal genetic variances.

    abstract::The estimation of maternal genetic variances by a multivariate maximum likelihood method is discussed. As an illustration the method is applied to data on Tribolium using a model based on partitioning the maternal genetic effect into additive and dominance components. An alternative model due to Falconer (1965) is als...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:

    authors: Thompson R

    更新日期:1976-12-01 00:00:00

  • A pairwise pseudo-likelihood approach for left-truncated and interval-censored data under the Cox model.

    abstract::Left truncation commonly occurs in many areas, and many methods have been proposed in the literature for the analysis of various types of left-truncated failure time data. For the situation, a common approach is to conduct the analysis conditional on truncation times, and the method is relatively simple but may not be...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/biom.13394

    authors: Wang P,Li D,Sun J

    更新日期:2020-10-15 00:00:00

  • Drawing inferences for high-dimensional linear models: A selection-assisted partial regression and smoothing approach.

    abstract::Drawing inferences for high-dimensional models is challenging as regular asymptotic theories are not applicable. This article proposes a new framework of simultaneous estimation and inferences for high-dimensional linear models. By smoothing over partial regression estimates based on a given variable selection scheme,...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/biom.13013

    authors: Fei Z,Zhu J,Banerjee M,Li Y

    更新日期:2019-06-01 00:00:00

  • Bayesian influence measures for joint models for longitudinal and survival data.

    abstract::This article develops a variety of influence measures for carrying out perturbation (or sensitivity) analysis to joint models of longitudinal and survival data (JMLS) in Bayesian analysis. A perturbation model is introduced to characterize individual and global perturbations to the three components of a Bayesian model...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.1541-0420.2012.01745.x

    authors: Zhu H,Ibrahim JG,Chi YY,Tang N

    更新日期:2012-09-01 00:00:00

  • A multilevel mixed effects varying coefficient model with multilevel predictors and random effects for modeling hospitalization risk in patients on dialysis.

    abstract::For patients on dialysis, hospitalizations remain a major risk factor for mortality and morbidity. We use data from a large national database, United States Renal Data System, to model time-varying effects of hospitalization risk factors as functions of time since initiation of dialysis. To account for the three-level...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/biom.13205

    authors: Li Y,Nguyen DV,Kürüm E,Rhee CM,Chen Y,Kalantar-Zadeh K,Şentürk D

    更新日期:2020-09-01 00:00:00

  • Joint models for a primary endpoint and multiple longitudinal covariate processes.

    abstract::Joint models are formulated to investigate the association between a primary endpoint and features of multiple longitudinal processes. In particular, the subject-specific random effects in a multivariate linear random-effects model for multiple longitudinal processes are predictors in a generalized linear model for pr...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.1541-0420.2007.00822.x

    authors: Li E,Wang N,Wang NY

    更新日期:2007-12-01 00:00:00

  • Sequential equivalence testing and repeated confidence intervals, with applications to normal and binary responses.

    abstract::We propose group sequential tests of the equivalence of two treatments based on ideas related to repeated confidence intervals. These tests adapt readily to unpredictable group sizes, to the possibility of continuing even though a boundary has been crossed, and to nonnormal observations. In comparing two binomial dist...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:

    authors: Jennison C,Turnbull BW

    更新日期:1993-03-01 00:00:00

  • Coregionalized single- and multiresolution spatially varying growth curve modeling with application to weed growth.

    abstract::Modeling of longitudinal data from agricultural experiments using growth curves helps understand conditions conducive or unconducive to crop growth. Recent advances in Geographical Information Systems (GIS) now allow geocoding of agricultural data that help understand spatial patterns. A particularly common problem is...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.1541-0420.2006.00535.x

    authors: Banerjee S,Johnson GA

    更新日期:2006-09-01 00:00:00

  • Adaptive decision making in a lymphocyte infusion trial.

    abstract::We describe an adaptive Bayesian design for a clinical trial of an experimental treatment for patients with hematologic malignancies who initially received an allogeneic bone marrow transplant but subsequently suffered a disease recurrence. Treatment consists of up to two courses of targeted immunotherapy followed by ...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.0006-341x.2002.00560.x

    authors: Thall PF,Inoue LY,Martin TG

    更新日期:2002-09-01 00:00:00

  • The effect of screening on some pretest-posttest test variances.

    abstract::The clinical trial design in which the endpoint is measured both at baseline and at the end of the study is used in a variety of situations. For two-group designs, test such as the t test or analysis of covariance are commonly used to evaluate treatment efficacy. Often such pretest-posttest trials restrict participati...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:

    authors: Follmann DA

    更新日期:1991-06-01 00:00:00

  • Comments about Joint Modeling of Cluster Size and Binary and Continuous Subunit-Specific Outcomes.

    abstract::In longitudinal studies and in clustered situations often binary and continuous response variables are observed and need to be modeled together. In a recent publication Dunson, Chen, and Harry (2003, Biometrics 59, 521-530) (DCH) propose a Bayesian approach for joint modeling of cluster size and binary and continuous ...

    journal_title:Biometrics

    pub_type: 评论,杂志文章

    doi:10.1111/j.1541-020X.2005.00409_1.x

    authors: Gueorguieva RV

    更新日期:2005-09-01 00:00:00

  • Random-effects models, for longitudinal data using Gibbs sampling.

    abstract::Analysis of longitudinal studies is often complicated through differences amongst individuals in the number and spacing of observations. Laird and Ware (1982, Biometrics 38, 963-974) proposed a linear random-effects model to deal with this problem. We propose a generalisation of this model to accommodate multiple rand...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:

    authors: Gilks WR,Wang CC,Yvonnet B,Coursaget P

    更新日期:1993-06-01 00:00:00

  • Further aspects of a Markovian sampling policy for water quality monitoring.

    abstract::In this paper, a Markov process is developed as a mathematical model to study the general problem of quality control monitoring. This approach was previously used by Arnold (1970) in development of sampling plans to study the water quality monitoring of streams. Arnold considered the expected sample size required for ...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:

    authors: Smeach SC,Jernigan RW

    更新日期:1977-03-01 00:00:00

  • The effect of conditional dependence on the evaluation of diagnostic tests.

    abstract::The accuracy of a new diagnostic test is often determined by comparison with a reference test which also has unknown error rates. Maximum likelihood estimation of the error rates of both tests is possible if they are simultaneously applied to two populations with different disease prevalences. The estimation procedure...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:

    authors: Vacek PM

    更新日期:1985-12-01 00:00:00

  • The gamma-frailty Poisson model for the nonparametric estimation of panel count data.

    abstract::In this article, we study nonparametric estimation of the mean function of a counting process with panel observations. We introduce the gamma frailty variable to account for the intracorrelation between the panel counts of the counting process and construct a maximum pseudo-likelihood estimate with the frailty variabl...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/j.0006-341x.2003.00126.x

    authors: Zhang Y,Jamshidian M

    更新日期:2003-12-01 00:00:00

  • Mixture models for estimating the size of a closed population when capture rates vary among individuals.

    abstract::We develop a parameterization of the beta-binomial mixture that provides sensible inferences about the size of a closed population when probabilities of capture or detection vary among individuals. Three classes of mixture models (beta-binomial, logistic-normal, and latent-class) are fitted to recaptures of snowshoe h...

    journal_title:Biometrics

    pub_type: 杂志文章

    doi:10.1111/1541-0420.00042

    authors: Dorazio RM,Royle JA

    更新日期:2003-06-01 00:00:00