Cetaben and fibrates both influence the activities of peroxisomal enzymes in different ways.


:The effects of cetaben and clofibric acid were compared on the activities of peroxisomal enzymes in the liver and kidney of male Wistar rats. Cetaben at 200 mg/kg body wt increased the activities of all of the enzymes in the liver that were studied two to eight times, whereas the changes induced by the same dose of clofibric acid increased some of the enzymes and decreased others. In the kidney, cetaben increased the activities of all investigated peroxisomal enzymes, while clofibric acid only increased the activity of palmitoyl-CoA oxidase. The data obtained in the dose-response study of cetaben revealed a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body wt administered over 10 days, but the maximal effect was observed at 250 mg/kg. Palmitoyl-CoA oxidase and D-amino acid oxidase respond most markedly to cetaben. Cetaben could represent an atypical peroxisomal proliferator, since it increased the activities of all peroxisomal enzymes investigated. The fact that the individual components localized in the peroxisomes do not change markedly could be of importance with respect to the function and physical properties of peroxisomes.


Biochem Pharmacol


Biochemical pharmacology


Chandoga J,Rojeková I,Hampl L,Hocman G




Has Abstract


1994-02-09 00:00:00














  • Specific, high-affinity bradykinin binding by purified porcine kidney post-proline cleaving enzyme.

    abstract::Post-proline cleaving enzyme (PPCE) was purified from porcine kidney cytosol. The purified enzyme bound [125I-Tyr5]-bradykinin but neither [125I-Tyr1]-kallidin nor [125I-Tyr8]-bradykinin. Scatchard analysis of the data was consistent with a single class of binding sites with a Kassoc = 1.3 +/- 0.1 X 10(8) M-1. The opt...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Odya CE,Dally RD,Georgiadis KE

    更新日期:1987-01-01 00:00:00

  • Modulation of [3H] TBOB binding to the rodent GABAA receptor by simple disaccharides.

    abstract::We have recently reported evidence that a simple beta-linked alkylated mannose reversibly increased the magnitude of GABA(A) receptor currents evoked in cultured rat pyramidal neurons whilst concomitantly reducing the incidence of spontaneous synaptic activity. In this present study, the effects of the simple beta-lin...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Rezai N,Duggan C,Cairns D,Lees G,Chazot PL

    更新日期:2003-02-15 00:00:00

  • Isolation and characterization at cholinergic nicotinic receptors of a neurotoxin from the venom of the Acanthophis sp. Seram death adder.

    abstract::The present study describes the isolation of the first neurotoxin (acantoxin IVa) from Acanthophis sp. Seram death adder venom and an examination of its activity at nicotinic acetylcholine receptor (nAChR) subtypes. Acantoxin IVa (MW 6815; 0.1-1.0 microM) caused concentration-dependent inhibition of indirect twitches ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Wickramaratna JC,Fry BG,Loiacono RE,Aguilar MI,Alewood PF,Hodgson WC

    更新日期:2004-07-15 00:00:00

  • Characterization of IRA/IRB hybrid insulin receptors using bioluminescence resonance energy transfer.

    abstract::The insulin receptor (IR) is composed of two alpha-chains that bind ligands and two beta-chains that possess an intracellular tyrosine kinase activity. The IR is expressed in cells as two isoforms containing or not exon 11 (IRB and IRA, respectively). Several mRNA studies have demonstrated that the two isoforms are co...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Blanquart C,Achi J,Issad T

    更新日期:2008-10-01 00:00:00

  • On Becoming a Pharmacologist: Channeling David Triggle.

    abstract::This Festschrift contribution summarizes the perspectives of two of David Triggle's graduate students. Both share somewhat parallel scientific and career paths-i.e., enrolling in the Biochemical Pharmacology program at the University of Buffalo, pursuing graduate training under the mentorship of David Triggle and subs...

    journal_title:Biochemical pharmacology

    pub_type: 历史文章,杂志文章,评审


    authors: Rampe D,Gopalakrishnan M

    更新日期:2015-11-15 00:00:00

  • Antioxidant-mediated attenuation of the induction of cytochrome P450BM-3(CYP102) by ibuprofen in Bacillus megaterium ATCC 14581.

    abstract::Bacillus megaterium contains a soluble cytochrome P450 termed BM-3, which is highly inducible by barbiturates, peroxisome proliferators, and nonsteroidal antiinflammatory drugs. In rats and mice, the chronic administration of peroxisome proliferators induces a sustained oxidative stress in hepatic tissue and may be re...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: English NT,Rankin LC

    更新日期:1997-08-15 00:00:00

  • Selective early loss of polypeptides in liver microsomes of CCl4-treated rats. Relationship to cytochrome P-450 content.

    abstract::Treatment of rats with carbon tetrachloride (CCl4) resulted in early reproducible losses of either one or two specific polypeptides (depending on the inducing agent with which the animals had been treated) in the molecular weight range of the multiple forms of cytochrome P-450. The loss was correlated with a decrease ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Noguchi T,Fong KL,Lai EK,Olson L,McCay PB

    更新日期:1982-03-01 00:00:00

  • Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast.

    abstract::A 1.57kb BamH1 fragment containing a full-length human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) cDNA was inserted into the BglII site of the yeast expression plasmid pMA91 and the resulting recombinant plasmid, PELT1, introduced into Saccharomyces cerevisiae strain AH22. Microsomes prepared from AH22/pELT1 ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Ellis SW,Ching MS,Watson PF,Henderson CJ,Simula AP,Lennard MS,Tucker GT,Woods HF

    更新日期:1992-08-18 00:00:00

  • Subcellular localization of a thromboxane A2/prostaglandin H2 receptor antagonist binding site in human platelets.

    abstract::The subcellular localization of a binding site for the competitive thromboxane A2/prostaglandin H2 (TXA2/PGH2) antagonist, 9,11-dimethylmethano-11,12-methano-16-(3-iodo-4- hydroxyphenyl)-13,14-dihydro-13-aza-15 alpha beta-omega-tetranor TXA2 ([125I]-PTA-OH), was determined. Subcellular fractions of platelets were prep...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Saussy DL Jr,Mais DE,Baron DA,Pepkowitz SH,Halushka PV

    更新日期:1988-02-15 00:00:00

  • On the binding of a 3-alpha-methylated digitoxigenin-glucoside to ouabain receptors in heart muscle homogenate.

    abstract::3-alpha-Methyl substituted digitoxigenin-3-beta-glucoside (methyl-dtg-gluc) displays unusual features, e.g. a high dissociation rate constant from its binding site leading to rapid reversibility of the inotropic and toxic effects, and a flat dose-response curve attaining higher inotropic maxima thus indicating an incr...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Lüllmann H,Mohr K

    更新日期:1982-08-01 00:00:00

  • Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress.

    abstract::Breast cancer is the leading cause of cancer death among females, and novel chemotherapeutic drugs for treating breast cancer are needed urgently. Saxifragifolin D (SD) was isolated by our group from Androsace umbellata which is commonly used to treat solid tumor. In this study, we evaluated its growth inhibitory effe...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Shi JM,Bai LL,Zhang DM,Yiu A,Yin ZQ,Han WL,Liu JS,Li Y,Fu DY,Ye WC

    更新日期:2013-04-01 00:00:00

  • Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells.

    abstract::In advanced stages of cancer disease, caveolin-1 (CAV1) expression increases and correlates with increased migratory and invasive capacity of the respective tumor cells. Previous findings from our laboratory revealed that specific ECM-integrin interactions and tyrosine-14 phosphorylation of CAV1 are required for CAV1-...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Ortiz R,Díaz J,Díaz-Valdivia N,Martínez S,Simón L,Contreras P,Lobos-González L,Guerrero S,Leyton L,Quest AFG

    更新日期:2020-07-01 00:00:00

  • Inhibition of leukotriene B4 formation in human neutrophils after oral nafazatrom (Bay g 6575).

    abstract::Three grams of nafazatrom (Bay g 6575), given orally to healthy male volunteers in a single dose, significantly reduce the formation of leukotriene B4 in polymorphonuclear leukocytes. LTB4 synthesis fell from 57.1 +/- 17.0 ng/10(7) PMNL, mean +/- S.D., in control to 34.3 +/- 14.4 ng/10(7) PMNL 3 hr after nafazatrom (2...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Strasser T,Fischer S,Weber PC

    更新日期:1985-06-01 00:00:00

  • Tenofovir alafenamide (TAF) as the successor of tenofovir disoproxil fumarate (TDF).

    abstract::Tenofovir alafenamide (TAF) can be considered a new prodrug of tenofovir (TFV), as successor of tenofovir disoproxil fumarate (TDF). It is in vivo as potent against human immunodeficiency virus (HIV) at a 30-fold lower dose (10mg) than TDF (300mg). TAF has been approved in November 2015 (in the US and EU), as a single...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: De Clercq E

    更新日期:2016-11-01 00:00:00

  • The in vitro ketone reduction of warfarin and analogues. Substrate stereoselectivity, product stereoselectivity and species differences.

    abstract::The in vitro metabolic ketone reduction of warfarin and its 4'-analogues acenocoumarol (4'-nitrowarfarin) and 4'-chlorowarfarin has been investigated using microsomal and cytosolic fractions of several species. Both subcellular fractions showed ketone reductase activity. The cytosolic fractions, in most species, exhib...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Hermans JJ,Thijssen HH

    更新日期:1989-10-01 00:00:00

  • Changes in rat hepatic microsomal mixed function oxidase activity following exposure to halothane under various oxygen concentrations.

    abstract::This study demonstrates that the exposure of phenobarbitone-treated rats to halothane at an oxygen concentration of either 10% or 14% results in marked decreases in cytochrome P-450 content and aminopyrine demethylase activity in animals sacrificed from 1 to 48 hr post-exposure. The alterations observed in the hepatic...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Knights KM,Gourlay GK,Cousins MJ

    更新日期:1987-03-15 00:00:00

  • Inhibition of cellular thymidylate synthesis by cytotoxic propenal derivatives of pyrimidine bases and deoxynucleosides.

    abstract::A series of cytotoxic propenal (3-oxoprop-1-enyl) derivatives of pyrimidine bases and deoxynucleosides was evaluated for their ability to block thymidylate synthesis in intact and permeabilized murine leukemia L1210 cells. Several were potent inhibitors of this process, likely contributing to their cytotoxicity. The I...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Kalman TI,Marinelli ER,Xu B,Reddy AR,Johnson F,Grollman AP

    更新日期:1991-07-05 00:00:00

  • Indirect evidence for the metabolic dehalogenation of tetrafluorodiethylstilbestrol by rat and hamster liver and kidney microsomes. Species- and organ-dependent differences.

    abstract::In order to assess the significance of the catechol pathway for the carcinogenic activity of diethylstilbestrol (DES), the stability of 3',5',3",5"-tetrafluoro-DES (TF-DES) against metabolic catechol formation was examined in vitro. A radioenzymatic assay was used for determining the estrogen hydroxylase activity of l...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Hey MM,Haaf H,McLachlan JA,Metzler M

    更新日期:1986-07-01 00:00:00

  • Chiral inversion of drug: role of intestinal bacteria in the stereoselective sulphoxide reduction of flosequinan.

    abstract::Chiral inversion at a sulphoxide position of flosequinan enantiomers [(+/-)-7-fluoro-1-methyl-3-methylsulphinyl-4-quinolone] occurred in conventional rats but not in either germ-free rats or rats treated with antibiotics after an oral administration of each enantiomer. Thus, it was postulated that the chiral inversion...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Kashiyama E,Yokoi T,Todaka T,Odomi M,Kamataki T

    更新日期:1994-07-19 00:00:00

  • Induction of integrin β3 in PGE₂-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin.

    abstract::We previously demonstrated that prostaglandin (PG) E₂ stimulates adhesion of mastocytoma P-815 cells (P-815 cells) to the Arg-Gly-Asp (RGD)-enriched matrix via the PGE₂ receptor subtype EP4 [Hatae N, Kita A, Tanaka S, Sugimoto Y, Ichikawa A. Induction of adherent activity in mastocytoma P-815 cells by the cooperation ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Okada Y,Nishikawa J,Semma M,Ichikawa A

    更新日期:2011-04-01 00:00:00

  • Identification of transmembrane domain 1 & 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor.

    abstract::The vasoactive urotensin-II (UII), a cyclic undecapeptide widely distributed in cardiovascular, renal and endocrine systems, specifically binds the UII receptor (UT receptor), a G protein-coupled receptor (GPCR). The involvement of this receptor in numerous pathophysiological conditions including atherosclerosis, hear...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Sainsily X,Cabana J,Holleran BJ,Escher E,Lavigne P,Leduc R

    更新日期:2014-11-15 00:00:00

  • Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: Impact on oxidative, inflammatory and apoptotic machineries.

    abstract::Epilepsy is one of the serious neurological sequelae of bacterial meningitis. Rifampicin, the well-known broad spectrum antibiotic, is clinically used for chemoprophylaxis of meningitis. Besides its antibiotic effects, rifampicin has been proven to be an effective neuroprotective candidate in various experimental mode...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Ali AE,Mahdy HM,Elsherbiny DM,Azab SS

    更新日期:2018-10-01 00:00:00

  • Effect of stereo and regiochemistry towards wild and multidrug resistant HIV-1 virus: viral potency of chiral PETT derivatives.

    abstract::Chiral derivatives of several substituted halopyridyl and thiazolyl PETT compounds were synthesized as non-nucleoside inhibitors of the reverse transcriptase (RT) enzyme of the human immunodeficiency virus (HIV-1). Molecular modeling studies indicated that because of the asymmetric geometry of the non-nucleoside inhib...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Venkatachalam TK,Mao C,Uckun FM

    更新日期:2004-05-15 00:00:00

  • Effect of mevinolin on cholesterol metabolism in obese and lean Zucker rats.

    abstract::Mevinolin is a potent competitive inhibitor of HMG-CoA reductase, the enzyme catalyzing the major rate-limiting step in cholesterol synthesis. In this study the drug was administered as an intragastric dose at 2.5 mg/kg/day to 10 to 12-week-old lean and obese Zucker female rats over a 5-day period. Mevinolin showed no...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: McCune SA,Jurin RR

    更新日期:1987-03-15 00:00:00

  • A novel form of cytochrome P-450 in beagle dogs. P-450-D3 is a low spin form of cytochrome P-450 but with catalytic and structural properties similar to P-450d.

    abstract::A form of cytochrome P-450, P-450-D3, cross reactive with antibodies to rat P-450d was purified from liver microsomes of polychlorinated biphenyl (PCB)-treated female Beagle dogs to an electrophoretic homogeneity. Judging from the result of sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS-PAGE), the molec...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Ohta K,Motoya M,Komori M,Miura T,Kitada M,Kamataki T

    更新日期:1989-01-01 00:00:00

  • A spin-label study of the correlation between stomatocyte formation and membrane fluidization of erythrocytes.

    abstract::Change in the membrane fluidity of human erythrocytes on transformation to stomatocytes was observed by ESR spectroscopy using 12-doxyl stearic acid or its methyl ester as a probe. When the transformation to stomatocytes was induced by four qualitatively different methods, i.e. (a) addition of cationic amphiphilic age...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Noji S,Takahashi T,Kon H

    更新日期:1982-10-15 00:00:00

  • Interaction of dimercaptosuccinic acid (DMSA) with angiotensin II on calcium mobilization in vascular smooth muscle cells.

    abstract::Dimercaptosuccinic acid (DMSA) was shown to lower blood pressure in rat models of arterial hypertension. Thus, there is evidence that-besides its chelating properties-DMSA has a direct vascular effect, e.g. through scavenging of reactive oxygen species (ROS). We speculated that, in addition, intracellular calcium mobi...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Kramer HJ,Mensikova V,Bäcker A,Meyer-Lehnert H,Gonick HC

    更新日期:2003-05-15 00:00:00

  • Covalent coupling of doxorubicin in protein microspheres is a major determinant of tumour drug disposition.

    abstract::Doxorubicin is shown to be present in albumin microspheres (10-40 microns) in two forms: the native drug and a fraction of drug covalently coupled to the protein matrix probably via glutaraldehyde. Upon trypsin digestion the fraction covalently coupled is released and can be resolved from native doxorubicin by high pe...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Cummings J,Willmott N,Marley E,Smyth J

    更新日期:1991-06-15 00:00:00

  • Comparison of the inducing effect of dehydroepiandrosterone on hepatic peroxisome proliferation-associated enzymes in several rodent species. A short-term administration study.

    abstract::The in-vivo effect of dehydroepiandrosterone (DHEA) on hepatic enzyme activities of rats, mice, hamsters and guinea pigs was investigated. After DHEA treatment (300 mg/kg body weight, per os, 14 days), the activities of peroxisomal beta-oxidation, catalase, carnitine acetyltransferase, carnitine palmitoyltransferase, ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Sakuma M,Yamada J,Suga T

    更新日期:1992-03-17 00:00:00

  • Suppressive effect of biscoclaurine alkaloids on agonist-induced activation of phospholipase A2 in rabbit platelets.

    abstract::The effect of biscoclaurine (bisbenzylisoquinoline) alkaloids on phospholipase A2 and C activation in signal transduction system of rabbit platelet was studied. Isotetrandrine, cepharanthine and berbamine inhibited the aggregation induced by collagen but not by other stimuli such as thrombin and arachidonic acid, whil...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Hashizume T,Yamaguchi H,Sato T,Fujii T

    更新日期:1991-02-01 00:00:00