Transfer of inflammatory cytokines across the placenta.

Abstract:

OBJECTIVE:The purpose of this study was to determine whether the placental transfer of interleukin (IL)-1alpha, IL-6, and tumor necrosis factor-alpha (TNF-alpha) occurs. METHODS:Four normal-term placentas were perfused for maternal-fetal transfer of the cytokines, 2 placentas for fetal-maternal transfer, and 4 additional placentas were used for an endogenous control. The ex vivo isolated cotyledon human placental perfusion model was used. The reference compound antipyrine was used to determine the transport fraction and clearance index of the cytokines. The cytokines were added to either the maternal or fetal circulations, and samples were collected for 1 hour in a constant-flow open circulation. Cytokine levels were compared between the study and control placentas. Concentrations of the cytokines were measured by sandwich enzyme immunoassay. RESULTS:The clearance index for the maternal-fetal transfer of IL-1alpha and TNF-alpha was 0.001, suggesting minimal transfer to the fetal circulation. The clearance index for IL-6 was 0.30, indicating transfer to the fetal circulation. When the cytokines were added to the fetal circulation, the clearance index for IL-1alpha was 0.001, again indicating minimal transfer. The clearance index for TNF-alpha in the fetal-maternal study was not determined. IL-6 had a clearance index of 0.23, which was similar to that observed with maternal-fetal transfer. IL-6 concentrations in the study placentas were higher than the concentrations found in the controls. CONCLUSION:There appears to be bidirectional transfer of IL-6 in the healthy-term human placental perfusion model. LEVEL OF EVIDENCE:II-2

journal_name

Obstet Gynecol

authors

Zaretsky MV,Alexander JM,Byrd W,Bawdon RE

doi

10.1097/01.AOG.0000114980.40445.83

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

546-50

issue

3

eissn

0029-7844

issn

1873-233X

pii

103/3/546

journal_volume

103

pub_type

杂志文章
  • Clinical application of fetal weight determination by real-time ultrasound measurements.

    abstract::The weights of 101 neonates delivered within 72 hours of real-time ultrasound examination were compared with the weight calculated from the ultrasonically measured biparietal diameter and abdominal circumference. A high degree of correlation (4 = .9624) was found between actual and calculated weights. This method of w...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Ott WJ

    更新日期:1981-06-01 00:00:00

  • Postmenarchal development of chylous ascites in acrocephalosyndactyly with congenital lymphatic dysplasia.

    abstract:BACKGROUND:Acrocephalosyndactyly is a syndrome characterized by congenital malformation of the skull with craniosynostosis, midface hypoplasia, and symmetrical webbed fusion of the fingers and toes. We describe a possible pathophysiologic mechanism for chylous ascites that developed several months after menarche in a w...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(00)01162-5

    authors: Batt RE,Michalski SR,Mahl T,Reynhout JC

    更新日期:2001-05-01 00:00:00

  • Intrauterine anesthesia for gynecologic procedures: a systematic review.

    abstract:OBJECTIVE:To assess the effectiveness of intrauterine local anesthesia in reducing pain associated with outpatient gynecologic procedures. DATA SOURCES:We searched online databases PubMed or MEDLINE, Embase, Google Scholar, and Clinicaltrials.gov and hand-searched reference lists from reviews evaluating pain-control m...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/AOG.0b013e3182639ab5

    authors: Mercier RJ,Zerden ML

    更新日期:2012-09-01 00:00:00

  • Perforation of the uterus and partial extrusion of a Lippes loop. Report of a case.

    abstract::This is a case report of a woman having an IUD which became partially extruded through the uterine wall and went undetected until the patient became pregnant. Severe metritis followed premature rupture of the membranes during the early part of the third trimester. Cesarean section hysterectomy led to a salutary outc...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Post DF

    更新日期:1969-12-01 00:00:00

  • Association of the Affordable Care Act With Ovarian Cancer Care.

    abstract:OBJECTIVE:To estimate how implementation of the 2010 Affordable Care Act (ACA) might be associated with stage at diagnosis and time to treatment for women with ovarian cancer. METHODS:We conducted a retrospective cohort study using difference-in-differences analysis comparing stage at diagnosis and time to treatment b...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000003630

    authors: Smith AJB,Fader AN

    更新日期:2020-02-01 00:00:00

  • Cervical intraepithelial neoplasia III: long-term outcome after cold-knife conization with clear margins.

    abstract:OBJECTIVE:To evaluate the long-term outcome of patients with severe cervical intraepithelial neoplasia or squamous cell carcinoma in situ (CIN III) after cold-knife conization with clear margins. METHODS:A total of 4417 women (mean age 36, range 18-72 years) with histologically confirmed CIN III had cold-knife conizat...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(00)01174-1

    authors: Reich O,Pickel H,Lahousen M,Tamussino K,Winter R

    更新日期:2001-03-01 00:00:00

  • Reclosure of the disrupted laparotomy wound: a systematic review.

    abstract:OBJECTIVE:To review systematically all prospective, randomized trials published in English quantifying the success of reclosure of the disrupted laparotomy wound. DATA SOURCES:The MEDLINE/PubMed, EMBASE, CINAHL, and Cochrane databases were searched from 1966 to 2004. References were hand-searched and their authors con...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.AOG.0000171114.75338.06

    authors: Wechter ME,Pearlman MD,Hartmann KE

    更新日期:2005-08-01 00:00:00

  • Mucinous cystadenocarcinoma of the retroperitoneum.

    abstract::A case of a primary retroperitoneal mucinous cystadenocarcinoma of ovarian type found at laparotomy in the presence of two normal ovaries is described. Careful examination of the tumor showed no evidence of ovarian tissue in the wall. The appearance of this tumor could be traced from areas of benign mucinous cystadeno...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Roth LM,Ehrlich CE

    更新日期:1977-04-01 00:00:00

  • The ultrasonographic appearance of ovarian ectopic pregnancies.

    abstract:OBJECTIVE:To evaluate the ultrasonographic findings of ovarian ectopic pregnancies. METHODS:The ultrasonographic reports, videotapes, medical records, and operative summaries were reviewed for all women with a confirmed diagnosis of an ovarian ectopic pregnancy. Examinations were personally conducted by a physician wh...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000148271.27446.30

    authors: Comstock C,Huston K,Lee W

    更新日期:2005-01-01 00:00:00

  • Fertility-conserving surgery for young women with stage IA1 cervical cancer: safety and access.

    abstract:OBJECTIVE:To estimate the safety of fertility-conserving surgery for stage IA1 cervical cancer and to analyze predictors of access to conization. METHODS:We analyzed women with stage IA1 cervical cancer aged 40 years or younger who were diagnosed between 1988 and 2005 and recorded in the Surveillance, Epidemiology, an...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e3181d06b68

    authors: Wright JD,Nathavithrana R,Lewin SN,Sun X,Deutsch I,Burke WM,Herzog TJ

    更新日期:2010-03-01 00:00:00

  • Urinary prostacyclin and thromboxane metabolites in drinking pregnant women and in their infants: relations to the fetal alcohol effects.

    abstract::To study the effect of maternal ethanol consumption on the production of prostacyclin and thromboxane, we measured urinary 6-keto-prostaglandin F1 alpha (a hydration product of prostacyclin), 2,3-dinor-6-keto-prostaglandin F1 alpha (generated from 6-keto-prostaglandin F1 alpha through beta oxidation), and thromboxane ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Ylikorkala O,Halmesmäki E,Viinikka L

    更新日期:1988-01-01 00:00:00

  • The use of quinidine sulfate throughout pregnancy.

    abstract::A gravid patient was given quinidine sulfate for idiopathic ventricular tachycardia. The serum levels of quinidine remained stable throughout pregnancy. At delivery, maternal and neonatal quinidine levels were equivalent, while the level in the amniotic fluid was significantly elevated. Explanations for the latter inc...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Hill LM,Malkasian GD Jr

    更新日期:1979-09-01 00:00:00

  • A rapid screening technic for detection of Y chromosomes.

    abstract::A rapid, simple method for screening individuals at high risk for the presence of Y chromosomes is described. The correlation with actual sex using probability tables from Baye's formula have shown to be accurate, when used with a 99% confidence limit. This procedure can be utilized in the investigation of amenorrhea ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Paulson JD,Keller DW,Muhlendorf K,Eatherly C

    更新日期:1976-12-01 00:00:00

  • Poor perinatal outcome associated with retained cerclage in patients with premature rupture of membranes.

    abstract:OBJECTIVE:To evaluate the role of immediate cerclage removal versus retention in patients experiencing premature rupture of the membranes remote from term (PROM). METHODS:Thirty patients with prophylactic cerclage experiencing PROM at 24-32 weeks were managed expectantly after either immediate removal in 20 (67%) or r...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Ludmir J,Bader T,Chen L,Lindenbaum C,Wong G

    更新日期:1994-11-01 00:00:00

  • Aggressive angiomyxoma of the vulva.

    abstract::An unusual myxoid and vascular appearing neoplasm of the vulva, termed an aggressive angiomyxoma, is described in a 36-year-old Hispanic woman. The clinical presentation and recurrence pattern were typical for previously described neoplasms of the same cellular pattern. The histopathology, difficulties in determining ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Hilgers RD,Pai R,Bartow SA,Aisenbrey G,Bowling MC

    更新日期:1986-09-01 00:00:00

  • Informed Consent and Shared Decision Making in Obstetrics and Gynecology: ACOG Committee Opinion, Number 819.

    abstract:ABSTRACT:Meeting the ethical obligations of informed consent requires that an obstetrician-gynecologist gives the patient adequate, accurate, and understandable information and requires that the patient has the ability to understand and reason through this information and is free to ask questions and to make an intenti...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000004247

    authors:

    更新日期:2021-02-01 00:00:00

  • Antenatal evaluation and management in nonimmune hydrops fetalis.

    abstract::Thirty-eight cases of nonimmune hydrops fetalis were evaluated by detailed real-time ultrasonography and two-dimensional echocardiography. Before ultrasound evaluation, all mothers had a complete blood count, titers for toxoplasmosis, rubella, cytomegalovirus, and herpes (TORCH screen), serum albumin, and a Kleihauer-...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Watson J,Campbell S

    更新日期:1986-04-01 00:00:00

  • Menstruation in young girls: a clinical perspective.

    abstract::The ACOG has recommended that the initial visit to an obstetrician-gynecologist for health guidance, screening, and provision of preventive services should take place around age 13-15. At this visit, clinicians can provide guidance to young girls and their parents on adolescent physical development based on data that ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1016/s0029-7844(02)01660-5

    authors: Adams Hillard PJ

    更新日期:2002-04-01 00:00:00

  • Committee Opinion No. 681 Summary: Disclosure and Discussion of Adverse Events.

    abstract::Adverse outcomes, preventable or otherwise, are a reality of medical care. Most importantly, adverse events affect patients, but they also affect health care practitioners. Disclosing information about adverse events has benefits for the patient and the physician and, ideally, strengthens the patient-physician relatio...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000001813

    authors:

    更新日期:2016-12-01 00:00:00

  • Learning curve in ultrasonographic screening for selected fetal structural anomalies in early pregnancy.

    abstract:OBJECTIVE:To assess the value of first trimester screening by ultrasonography in detecting structural anomalies of the fetus in a general obstetric population. METHODS:During 1993-1998, 20,465 consecutive pregnant women who resided in a defined geographic area participated in ultrasonographic screening for major malfo...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(02)02590-5

    authors: Taipale P,Ammälä M,Salonen R,Hiilesmaa V

    更新日期:2003-02-01 00:00:00

  • A simple test for predicting pregnancy-induced hypertension.

    abstract::One hundred thirty-one nulliparous patients between 28 to 34 weeks' gestation with no known history of renal disease or hypertension were placed in the left lateral recumbent position and their blood pressures were taken once and recorded. They then turned to the supine position where another blood pressure was taken ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Peck TM

    更新日期:1977-11-01 00:00:00

  • Uterine contractility and placental histology in abortion by laminaria and metreurynter.

    abstract::Abortions by cervical dilatation with laminaria tents followed by placement of a metreurynter into the lower uterine cavity to provide a mechanical stretch (the method most often used in midterm abortions in Japan) was performed in 7 normal Japanese and American women, 19-24 weeks pregnant, to determine similarities ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Manabe Y,Nakajima A,Griggs JF

    更新日期:1973-05-01 00:00:00

  • Peripartum changes in maternal cerebral blood flow velocity in normotensive and preeclamptic patients.

    abstract:OBJECTIVE:To compare the effect of delivery on cerebral blood flow velocity between normotensive and preeclamptic women, adjusting for mode of delivery and change in hematocrit values. METHODS:Twenty-three normotensive and 46 preeclamptic women had maternal middle cerebral blood flow velocity assessed antepartum and a...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Williams KP,McLean C

    更新日期:1993-09-01 00:00:00

  • Second-Trimester Fetal Loss in a Patient With Hyperemesis Gravidarum Complicated by Refeeding Syndrome.

    abstract:BACKGROUND:Refeeding syndrome is a rare constellation of electrolyte abnormalities after reintroduction of glucose during an adaptive state of starvation and malnutrition, resulting in fluid shifts, end-organ damage, and, potentially, death. We present a case of fetal death in a patient with hyperemesis gravidarum comp...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000003276

    authors: Mayer KH,McGill AL

    更新日期:2019-06-01 00:00:00

  • Retrograde ejaculation: successful treatment with artificial insemination.

    abstract::Retrograde ejaculation is characterized by aspermia or oligospermia and results from an incompetent bladder neck, often due to a dysfunction of the internal sphincter. In almost 3 years, eight couples who suffered from infertility due to retrograde ejaculation were treated with inseminations with spermatozoa gained fr...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: van der Linden PJ,Nan PM,te Velde ER,van Kooy RJ

    更新日期:1992-01-01 00:00:00

  • Hysterectomy for benign indications and risk of pelvic organ fistula disease.

    abstract:OBJECTIVE:To study the association between hysterectomy for benign indications and pelvic organ fistula disease. METHODS:We conducted a nationwide cohort study based on Swedish health care registers. The cohort consisted of 182,641 women having hysterectomy (exposed cohort) and 525,826 women not undergoing the procedu...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e3181b2a1df

    authors: Forsgren C,Lundholm C,Johansson ALV,Cnattingius S,Altman D

    更新日期:2009-09-01 00:00:00

  • Paracervical block efficacy in office hysteroscopic sterilization: a randomized controlled trial.

    abstract:OBJECTIVE:To estimate the efficacy of paracervical block compared with saline for pain relief during office hysteroscopic sterilization. METHODS:This study was a randomized, placebo-controlled study of women desiring hysteroscopic sterilization. A paracervical block of 1% lidocaine or normal saline was administered be...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/AOG.0b013e3181c51ace

    authors: Chudnoff S,Einstein M,Levie M

    更新日期:2010-01-01 00:00:00

  • A clinical and microbiologic analysis of risk factors for puerperal endometritis.

    abstract::Predictors of postpartum endometritis were identified in 607 asymptomatic, laboring women. One hundred (16.5%) developed postpartum endometritis. Multivariate analysis using stepwise logistic regression identified cesarean delivery (relative risk 12.8; P less than .0001) as the dominant overall predictor. In patients ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Newton ER,Prihoda TJ,Gibbs RS

    更新日期:1990-03-01 00:00:00

  • Abortion at 18-22 weeks by laminaria dilation and evacuation.

    abstract:OBJECTIVE:To evaluate the complications of late second-trimester abortions (18-22 weeks) by laminaria dilation and evacuation, and the obstetric outcome of subsequent pregnancies. METHODS:Dilation of the cervix was achieved by repeated laminaria tent replacement. Evacuation was carried out in the outpatient clinic usi...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0029-7844(96)00170-6

    authors: Schneider D,Halperin R,Langer R,Caspi E,Bukovsky I

    更新日期:1996-09-01 00:00:00

  • Neurodevelopmental Outcomes After Assisted Reproductive Technologies.

    abstract:OBJECTIVE:To compare children's cognitive, motor, and language development at 2 years of age after assisted reproductive technologies (ARTs) relative to natural conception. METHODS:The 3D-Study (2010-2012) is a prospective cohort study, which sought to improve the understanding among perinatal events, obstetric outcom...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000001837

    authors: Balayla J,Sheehy O,Fraser WD,Séguin JR,Trasler J,Monnier P,MacLeod AA,Simard MN,Muckle G,Bérard A,3D-Study Research Group From the Integrated Research Network in Perinatology of Quebec and Eastern Ontario.

    更新日期:2017-02-01 00:00:00