Urinary prostacyclin and thromboxane metabolites in drinking pregnant women and in their infants: relations to the fetal alcohol effects.


:To study the effect of maternal ethanol consumption on the production of prostacyclin and thromboxane, we measured urinary 6-keto-prostaglandin F1 alpha (a hydration product of prostacyclin), 2,3-dinor-6-keto-prostaglandin F1 alpha (generated from 6-keto-prostaglandin F1 alpha through beta oxidation), and thromboxane B2 (a hydration product of thromboxane A2) using consequent high-performance liquid chromatography and radioimmunoassays in 39 drinking women and 16 abstinent controls, and in their infants. Thirty-one drinkers and two control women smoked. Maternal ethanol consumption was accompanied by increased output of prostacyclin and thromboxane metabolites in the mothers, but no relationship was apparent between the increased metabolites and development of fetal alcohol effects in 22 mothers. There were no differences between smoking and nonsmoking drinkers in the excretion of these prostanoids. All the infants born to the drinkers had increased thromboxane B2 excretion, but the excretion of prostacyclin metabolites was increased only in infants with fetal alcohol effects. The ratio between prostacyclin and thromboxane was reduced in infants with fetal alcohol effects. Thus, maternal ethanol consumption is associated with enhanced prostacyclin and thromboxane synthesis, perhaps in the kidneys and/or systemic circulation and vascular bed. Similar changes may also occur in the fetus and/or newborn with fetal alcohol effects.


Obstet Gynecol


Ylikorkala O,Halmesmäki E,Viinikka L


Has Abstract


1988-01-01 00:00:00












  • Conservative management of maternal cervical vertebral hemangioma complicating pregnancy.

    abstract:BACKGROUND:Although vertebral hemangiomas are found in 10% of the population, they rarely become symptomatic. We describe management of an enlarging cervical vertebral hemangioma during pregnancy. CASE:A primiparous woman at 33 weeks of gestation presented with neck pain and paresthesias. She had a known cervical hema...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Foster L,Davidson K,Egerman R

    更新日期:2015-03-01 00:00:00

  • Management of interstitial ectopic pregnancies with a combined intra-amniotic and systemic approach.

    abstract:BACKGROUND:Approximately 2% of all pregnancies are ectopic; of these, 4% are interstitial or cervical. There exists no clear consensus as to whether surgical or medical management is superior. CASE:We present three cases of advanced nonfallopian tube ectopic pregnancies from 6 to 8 weeks of gestation. Our first two ca...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Swank ML,Harken TR,Porto M

    更新日期:2013-08-01 00:00:00

  • The preterm prediction study: fetal fibronectin testing and spontaneous preterm birth. NICHD Maternal Fetal Medicine Units Network.

    abstract:OBJECTIVE:To evaluate the presence of fetal fibronectin in the cervix and vagina as a screening test for spontaneous preterm birth. METHODS:Two thousand nine hundred twenty-nine women at ten centers were routinely screened every 2 weeks from 22-24 to 30 weeks for cervical and vaginal fetal fibronectin. A positive test...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究


    authors: Goldenberg RL,Mercer BM,Meis PJ,Copper RL,Das A,McNellis D

    更新日期:1996-05-01 00:00:00

  • Experience with midtrimester abortion.

    abstract::The midtrimester abortion program at a large community hospital was evaluated. During the 3-year study, 1839 patients aborted in the midtrimester by intraamniotic injection of hypertonic saline, prostaglandin F2alpha or a combination of saline and prostaglandin F2alpha. The method, using a combination of saline and pr...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Pahl IR,Lundy LE

    更新日期:1979-05-01 00:00:00

  • Amniotic fluid cortisol as an index of fetal lung maturity.

    abstract::Amniotic fluid cortisol concentration was compared with lecithin/sphingomyelin ratio, gestational age, and eventual birth-weight in a large series of normal and high-risk human pregnancies in an effort to determine whether cortisol could be used as a reliable indicator of fetal maturity. It appears that when used alon...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Gewolb IH,Hobbins JC,Tan SY

    更新日期:1977-04-01 00:00:00

  • Abortion training in Canadian obstetrics and gynecology residency programs.

    abstract:OBJECTIVE:To study abortion training in Canadian obstetrics and gynecology (ob-gyn) residency programs. METHODS:An anonymous questionnaire was sent to all postgraduate year (PGY)-4 and PGY-5 ob-gyn residents (n=130) and residency program directors (n=16) in Canada. The questionnaires inquired about demographic informa...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Roy G,Parvataneni R,Friedman B,Eastwood K,Darney PD,Steinauer J

    更新日期:2006-08-01 00:00:00

  • Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined.

    abstract:OBJECTIVE:To analyze the change in serial human chorionic gonadotropin (hCG) levels in women symptomatic with pain or bleeding who presented with nondiagnostic ultrasonography but were ultimately confirmed to have a viable intrauterine pregnancy. METHODS:The rise in serial hCG measures were modeled over time, with the...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Barnhart KT,Sammel MD,Rinaudo PF,Zhou L,Hummel AC,Guo W

    更新日期:2004-07-01 00:00:00

  • Improving care for depression in obstetrics and gynecology: a randomized controlled trial.

    abstract:OBJECTIVE:To evaluate an evidence-based collaborative depression care intervention adapted to obstetrics and gynecology clinics compared with usual care. METHODS:A two-site, randomized controlled trial included screen-positive women (Patient Health Questionnaire-9 score of at least 10) who met criteria for major depre...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Melville JL,Reed SD,Russo J,Croicu CA,Ludman E,LaRocco-Cockburn A,Katon W

    更新日期:2014-06-01 00:00:00

  • Practice Bulletin No. 161 Summary: External Cephalic Version.

    abstract::In the United States, there is a widespread belief that the overall cesarean delivery rate is higher than necessary. Efforts are being directed toward decreasing the number of these procedures, in part by encouraging physicians to make changes in their management practices. Because breech presentations are associated ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审


    authors: American College of Obstetricians and Gynecologists' Committee on Practice Bulletins--Obstetrics.

    更新日期:2016-02-01 00:00:00

  • Hormonal treatment of an endometrial stromal nodule followed by local excision.

    abstract:BACKGROUND:Endometrial stromal nodule is a rare subtype of endometrial stromal tumor. Although such nodules are benign, hysterectomy has been considered the treatment of choice, because evaluation of the margin is required for diagnosis. The similarity between low-grade stromal sarcoma and stromal nodule suggests that ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Schilder JM,Hurd WW,Roth LM,Sutton GP

    更新日期:1999-05-01 00:00:00

  • Transurethral bladder eversion concurrent with uterovaginal prolapse.

    abstract:BACKGROUND:Transurethral bladder eversion is rare. A case of transurethral bladder eversion with concurrent uterovaginal prolapse is presented. CASE:The patient was postmenopausal, had a long history of uterovaginal prolapse, and developed bladder eversion. Examination under anesthesia revealed full-thickness transure...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Mastropietro MA,Clark MH,Hale DS

    更新日期:2002-05-01 00:00:00

  • Magnetic resonance imaging in Mayer-Rokitansky-Küster-Hauser syndrome.

    abstract::Six girls with suspected Rokitansky syndrome underwent magnetic resonance imaging (MRI) and then sonography and laparoscopy to confirm the clinical diagnosis and define the precise characteristics of the malformation. The uterus was missing in all; four had müllerian rudiments in place of the uterus, which were cavita...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Fedele L,Dorta M,Brioschi D,Giudici MN,Candiani GB

    更新日期:1990-10-01 00:00:00

  • Infant mortality and early postpartum discharge.

    abstract:OBJECTIVE:To assess additional risk of newborn death owing to early discharge. METHODS:This was a historical cohort study using Washington State linked birth certificates, death certificates, and hospital discharge records that covered 47,879 live births in 1989 and 1990. Logistic regression was used to assess risk of...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Malkin JD,Garber S,Broder MS,Keeler E

    更新日期:2000-08-01 00:00:00

  • Decreased plasma tryptophan in pregnancy.

    abstract:OBJECTIVE:To examine levels of serum tryptophan and its degradation product kynurenine in uncomplicated pregnancy, according to the week of pregnancy and the concentrations of neopterin. METHODS:Plasma was analyzed from 45 healthy pregnant women (15 in each trimester), 15 healthy puerperas, and 20 nonpregnant controls...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Schröcksnadel H,Baier-Bitterlich G,Dapunt O,Wachter H,Fuchs D

    更新日期:1996-07-01 00:00:00

  • Endometriosis associated with ascites.

    abstract::Pelvic endometriosis associated with massive ascites is an unusual occurrence. Only 12 cases have been reported since 1954 when Brews first described this entity. The authors present two cases recently encountered at Saga Medical School Hospital. Clinical courses and operative findings are described and other cases fr...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Iwasaka T,Okuma Y,Yoshimura T,Kidera Y,Sugimori H

    更新日期:1985-09-01 00:00:00

  • Effect of ritodrine on labor after premature rupture of the membranes.

    abstract::The effect on labor of administering ritodrine after a premature rupture of the membranes (PROM) was studied in a double-blind trial in 30 patients. The patients were selected according to the following criteria: 28 to 36 weeks' gestation, only 1 fetus, cervix dilated 4 cm or less, and absence of pyrexia or other sign...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章


    authors: Christensen KK,Ingemarsson I,Leideman T,Solum T,Svenningsen N

    更新日期:1980-02-01 00:00:00

  • Retention of intrauterine fetal bone increases menstrual prostaglandins.

    abstract::Intrauterine retention of fetal bone is a rare complication of abortion that can cause secondary infertility by an unknown mechanism. We report such a case in which menstrual fluid prostanoids were measured to elucidate the possible pathophysiology. The pattern of prostanoid increases was similar to that seen in intra...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Lewis V,Khan-Dawood F,King M,Beckmann C,Dawood MY

    更新日期:1990-03-01 00:00:00

  • Placenta previa percreta involving the urinary bladder: a report of two cases and review of the literature.

    abstract::The incidences of both placenta previa and placenta accreta are increased in patients with scarred uteri, and patients with uterine scars and placenta previa are at increased risk for also having placenta accreta. Two cases are presented of placenta previa percreta with involvement of the urinary bladder necessitating...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审


    authors: Price FV,Resnik E,Heller KA,Christopherson WA

    更新日期:1991-09-01 00:00:00

  • Fetal nucleated cells in maternal peripheral blood after delivery in cases of fetomaternal hemorrhage.

    abstract:OBJECTIVE:To determine how long fetal nucleated cells can be detected in maternal peripheral blood after delivery in cases of fetomaternal hemorrhage, using fluorescence in situ hybridization or polymerase chain reaction. METHODS:Nucleated cells with Y chromosomes were analyzed in 90 blood samples using fluorescence i...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Hamada H,Arinami T,Hamaguchi H,Kubo T

    更新日期:1995-03-01 00:00:00

  • Medical Education and Safety as Co-priorities in the Coronavirus Disease 2019 (COVID-19) Era: We Can Do Both.

    abstract::As hospitals and medical schools confronted coronavirus disease 2019 (COVID-19), medical students were essentially restricted from all clinical work in an effort to prioritize their safety and the safety of others. One downstream effect of this decision was that students were designated as nonessential, in contrast to...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Baecher-Lind L,Fleming AC,Bhargava R,Cox SM,Everett EN,Graziano SC,Katz NT,Sims SM,Morgan HK,Morosky CM,Sonn TS,Sutton JM,Royce CS,Association of Professors of Gynecology and Obstetrics Undergraduate Medical Education Committee

    更新日期:2020-10-01 00:00:00

  • Social support in improving perinatal outcome: the Resource Mothers Program.

    abstract::This report studies the Resource Mothers Program, an organization that improves perinatal outcome through social support. Resource Mothers are nonprofessional women who combine warmth, parenting experience, and knowledge of their local community services to reduce the hazards associated with rural adolescent pregnancy...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Heins HC Jr,Nance NW,Ferguson JE

    更新日期:1987-08-01 00:00:00

  • Diagnostic accuracy of fetal heart rate monitoring in the identification of neonatal encephalopathy.

    abstract:OBJECTIVE:To estimate the diagnostic accuracy of electronic fetal heart rate abnormalities in the identification of neonates with encephalopathy treated with whole-body hypothermia. METHODS:Between January 1, 2007, and July 1, 2013, there were 39 neonates born at two hospitals within our system treated with whole-body...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Graham EM,Adami RR,McKenney SL,Jennings JM,Burd I,Witter FR

    更新日期:2014-09-01 00:00:00

  • Massive blood transfusion during hospitalization for delivery in New York State, 1998-2007.

    abstract:OBJECTIVE:To define the frequency, risk factors, and outcomes of massive transfusion in obstetrics. METHODS:The State Inpatient Dataset for New York (1998-2007) was used to identify all delivery hospitalizations for hospitals that reported at least one delivery-related transfusion per year. Multivariable logistic regr...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Mhyre JM,Shilkrut A,Kuklina EV,Callaghan WM,Creanga AA,Kaminsky S,Bateman BT

    更新日期:2013-12-01 00:00:00

  • Uterine sarcoidosis potentially associated with interferon-alpha use for chronic hepatitis C infection.

    abstract:BACKGROUND:A regimen including interferon-alpha has become the standard of care in the treatment of chronic hepatitis C over the last decade. One rare adverse effect associated with the use of interferon-alpha is a granulomatous pulmonary reaction. CASE:A unique case of uterine sarcoidosis associated with the use of i...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Tsiodras S,Drimala P,Stavreas N,Dachlythras M,Alamani AM,Naoum G

    更新日期:2005-05-01 00:00:00

  • Transvaginal sonographic detection of embryonic-fetal abnormalities in early pregnancy.

    abstract:OBJECTIVE:To estimate the detection rate of abnormalities by transvaginal ultrasound in early pregnancy. METHODS:We prospectively analyzed records of 3592 sequential pregnant women at 10-16 weeks' (singleton) gestation (mean 13 weeks and 2 days). After exclusion of 114 women, there were 3478 women in the study. Each w...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Guariglia L,Rosati P

    更新日期:2000-09-01 00:00:00

  • Complex atypical endometrial hyperplasia: the risk of unrecognized adenocarcinoma and value of preoperative dilation and curettage.

    abstract:OBJECTIVE:To evaluate whether preoperative dilation and curettage (D&C) lowers the risk of unexpected cancer at hysterectomy. METHODS:Women with complex atypical endometrial hyperplasia on sampling from January 2000 to May 2008 who underwent hysterectomy within 6 months were identified using a pathology database. Pati...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Suh-Burgmann E,Hung YY,Armstrong MA

    更新日期:2009-09-01 00:00:00

  • Higher Risk of Homicide Among Pregnant and Postpartum Females Aged 10-29 Years in Illinois, 2002-2011.

    abstract:OBJECTIVE:To examine whether being pregnant or postpartum was associated with excess risk for homicide among females in Illinois and to describe the association between pregnancy status and homicide by race, ethnicity, and age group. METHODS:This is a retrospective, multicohort, ecologic study of females of reproducti...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Koch AR,Rosenberg D,Geller SE,Illinois Department of Public Health Maternal Mortality Review Committee Working Group.

    更新日期:2016-09-01 00:00:00

  • Histologic prognosticators in stage I squamous cell carcinoma of the vulva.

    abstract::Sixty-four cases of stage I vulvar squamous cell carcinoma were analyzed histologically to define a patient subset at minimum risk for recurrence or nodal metastases. Three patterns of invasion were predefined: carcinoma in situ with early stromal invasion (33%), pushing (8%), and infiltrative (59%). Infiltrative patt...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Ross MJ,Ehrmann RL

    更新日期:1987-11-01 00:00:00

  • Prenatal diagnosis of neural tube defects. IV. Maternal serum alpha-fetoprotein screening.

    abstract::The maternal serum alpha-fetoprotein (AFP) in 6161 women in routine pregnancy [2771 in a hospital obstetric clinic (group 1) and 3390 in private practices (group 2)] was studied. Group 1 studies enabled the delineation of the normal range of serum AFP, whereas group 2 represented a true screening experience. In group ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Milunsky A,Alpert E,Neff RK,Frigoletto FD Jr

    更新日期:1980-01-01 00:00:00

  • The genetics of intersexuality: clinical and theoretic perspectives.

    abstract::Recent studies using newly devised serologic techniques have dramatically advanced our understanding of gonadal organogenesis and aberrant sexual differentiation. Thus XY gonadal dysgenesis, XX male syndrome, and XX true hermaphroditism, for example, may be seen as typifying specific errors of regulation, synthesis, o...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审


    authors: Wachtel SS

    更新日期:1979-12-01 00:00:00