Alpha(2A)-adrenergic versus imidazoline receptor controversy in rilmenidine's action: alpha(2A)-antagonism in humans versus alpha(2A)-agonism in rabbits.

Abstract:

:At the alpha(2A)-autoreceptors on the sympathetic nerve terminals of the human atrial appendages and rabbit pulmonary artery, rilmenidine and oxymetazoline exhibit different properties (antagonism and agonism, respectively). These opposite pharmacodynamic properties of alpha(2)-adrenoceptor ligands seem to be due to substantial differences in the nucleotide and amino acid sequences between human and rabbit alpha(2A)-adrenoceptors. Hence, the rabbit alpha(2A)-adrenoceptor is not reliably predictive for the action of ligands at the human alpha(2A)-adrenoceptor.

journal_name

Ann N Y Acad Sci

authors

Molderings GJ,Bonisch H,Bruss M,Gothert M

doi

10.1196/annals.1304.036

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

279-82

eissn

0077-8923

issn

1749-6632

journal_volume

1009

pub_type

杂志文章
  • Synthetic wisdom.

    abstract::Wisdom is a special kind of virtue. It is not to be identified with any outstanding cognitive ability-like having a prodigious memory or knowing a lot. Rather it consists in seeing what is most important and most valuable, either within a particular domain or in life as a whole. In the life of a wise person, that insi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13212

    authors: Kitcher P

    更新日期:2016-11-01 00:00:00

  • Cyclic AMP-dependent signaling aberrations in macronodular adrenal disease.

    abstract::The adrenal glands are a major source of steroid hormone biosynthesis. In normal physiology, the pituitary hormone corticotropin (ACTH) regulates the secretion of glucocorticoids via its G protein-coupled receptor (ACTHR), the product of the MC2R gene. Aldosterone is another major product of the adrenal gland; its reg...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb04339.x

    authors: Bourdeau I,Stratakis CA

    更新日期:2002-06-01 00:00:00

  • Relaxin-induced changes in renal function and RXFP1 receptor expression in the female rat.

    abstract::Relaxin causes renal hyperfiltration, natriuresis, and diuresis in male rats. This study determined the effect of recombinant human relaxin (rhRLX) on renal function in the female rat. After 7 days of rhRLX treatment (0.4 microg/h) urinary excretion of sodium and chloride were significantly lower in the rhRLX-treated ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2008.03797.x

    authors: Bogzil AH,Ashton N

    更新日期:2009-04-01 00:00:00

  • The stimulated social brain: effects of transcranial direct current stimulation on social cognition.

    abstract::Transcranial direct current stimulation (tDCS) is an increasingly popular noninvasive neuromodulatory tool in the fields of cognitive and clinical neuroscience and psychiatry. It is an inexpensive, painless, and safe brain-stimulation technique that has proven to be effective in modulating cognitive and sensory-percep...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13098

    authors: Sellaro R,Nitsche MA,Colzato LS

    更新日期:2016-04-01 00:00:00

  • The genetic basis of precursor supply for the biosynthesis of macrolide and polyether antibiotics.

    abstract::Macrolide and polyether biosynthesis in actinomycetes is regulated at the level of precursor supply by effects of nutrients on the sources of the low-molecular-weight fatty acids used to build the carbon framework of these antibiotics. Ammonium ion appears to suppress the first enzymes of valine and threonine cataboli...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1994.tb47382.x

    authors: Tang L,Zhang YX,Hutchinson CR

    更新日期:1994-05-02 00:00:00

  • Protecting the privacy of patient information in clinical networks: regulatory effectiveness analysis.

    abstract::Patient privacy is one of the major issues in the development of modern clinical information system networks. Such networks will have to demonstrate an appropriate concern for privacy as a precondition of operation. Regulatory effectiveness analysis is a novel technique for measuring compliance with a technological re...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1992.tb26090.x

    authors: Brannigan VM

    更新日期:1992-12-17 00:00:00

  • Novel bioartificial liver support system: preclinical evaluation.

    abstract::Preclinical safety and efficacy evaluation of a novel bioartificial liver support system (BLSS) was conducted using a D-galactosamine canine liver failure model. The BLSS houses a suspension of porcine hepatocytes in a hollow fiber cartridge with the hepatocytes on one side of the membrane and whole blood flowing on t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb08516.x

    authors: Patzer JF 2nd,Mazariegos GV,Lopez R,Molmenti E,Gerber D,Riddervold F,Khanna A,Yin WY,Chen Y,Scott VL,Aggarwal S,Kramer DJ,Wagner RA,Zhu Y,Fulmer ML,Block GD,Amiot BP

    更新日期:1999-06-18 00:00:00

  • Genetic code: an alternative model of translation.

    abstract::Our earlier studies of translation have led us to a specific numeric coding of nucleotides (A = 0, C = 1, G = 2, and U = 3)--that is, a quaternary numeric system; to ordering of digrams and codons (read right to left: .yx and Z.yx) as ordinal numbers from 000 to 111; and to seek hypothetic transformation of mRNA to 20...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1342.081

    authors: Damjanović ZM,Rakocević MM

    更新日期:2005-06-01 00:00:00

  • Tight junctions on the move: molecular mechanisms for epithelial barrier regulation.

    abstract::Increasing evidence suggests that the tight junction is a dynamically regulated structure. Cytoskeletal reorganization, particularly myosin light chain phosphorylation--induced actomyosin contraction, has increasingly been recognized as a mediator of physiological and pathophysiological tight junction regulation. Howe...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2012.06613.x

    authors: Shen L

    更新日期:2012-07-01 00:00:00

  • Effect of indoor lighting on normal skin.

    abstract::A small but measurable component of some indoor lighting is ultraviolet radiation (UVR); whether it is sufficient to modify the indoor worker's risk for chronic skin changes is not directly answerable with available technology. A first approach to this question involves a) estimating a range of annual background solar...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1985.tb11819.x

    authors: Cole C,Forbes PD,Davies RE,Urbach F

    更新日期:1985-01-01 00:00:00

  • Ketoconazole treatment of coccidioidal meningitis.

    abstract::Fifteen patients with coccidioidal meningitis were treated with high doses of ketoconazole for up to 4 years. Five patients were treated with ketoconazole alone. One clinically failed, one developed hepatotoxicity, and three achieved remission of meningitis. One patient received intrathecal AMB in addition to ketocona...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1988.tb40446.x

    authors: Graybill JR,Stevens DA,Galgiani JN,Sugar AM,Craven PC,Gregg C,Huppert M,Cloud G,Dismukes WE

    更新日期:1988-01-01 00:00:00

  • Reproductive aging: theoretical perspectives, mechanisms, nonhuman models, and health correlates.

    abstract::Every 365.2421999 days--more or less--the earth rotates, revolves, wobbles, and precesses along an elliptical path around the sun. Those of us who survive the journey are a year older: we have aged one solar year. Some years we seem to age faster than other years; some people seem to age faster than other people; some...

    journal_title:Annals of the New York Academy of Sciences

    pub_type:

    doi:10.1111/j.1749-6632.2010.05700.x

    authors: Haaga J,O'Connor K,Weinstein M,Wise P

    更新日期:2010-08-01 00:00:00

  • Developmental plasticity of central serotonin neurons after 5,7-dihydroxytryptamine treatment.

    abstract::Systemic administration of 5,7-HT to newborn rats produces an altered development of the 5-HT neurons in the central nervous system, with marked regional differences. 5,7-Hydroxytryptamine can enter the brain and elicit its neurotoxic actions after systemic administration in the neonatal stage due to an incompletely d...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1978.tb31532.x

    authors: Jonsson G,Pollare T,Hallman H,Sachs C

    更新日期:1978-06-12 00:00:00

  • Sex, sex differences, and social behavior.

    abstract::Sex differences in social behavior are center stage in recent formulations of evolutionary psychology. Evolutionary psychology, with its emphasis on the long-term consequences of early adaptations, offers itself as an alternative meta-theory to mainstream social psychology, which emphasizes the importance of social st...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06625.x

    authors: Rabinowitz VC,Valian V

    更新日期:2000-04-01 00:00:00

  • Combined neurostimulation and neuroimaging in cognitive neuroscience: past, present, and future.

    abstract::Modern neurostimulation approaches in humans provide controlled inputs into the operations of cortical regions, with highly specific behavioral consequences. This enables causal structure-function inferences, and in combination with neuroimaging, has provided novel insights into the basic mechanisms of action of neuro...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12110

    authors: Bestmann S,Feredoes E

    更新日期:2013-08-01 00:00:00

  • Different vaccine strategies used to protect against Theileria annulata.

    abstract::SPAG-1, a sporozoite surface antigen of T. annulata, has previously been shown to elicit partial protection when used, as an hepatitis B core antigen fusion, to immunize cattle. The objective of this study was to try and improve the protective capacity of this antigen by enlisting different vaccine strategies. Cattle ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb11054.x

    authors: Boulter NR,Brown CG,Kirvar E,Glass E,Campbell J,Morzaria S,Nene V,Musoke A,D'Oliveira C,Gubbels MJ,Jongejan F,Hall FR

    更新日期:1998-06-29 00:00:00

  • Differential regulation of apoptosis by ischemia-reperfusion and ischemic adaptation.

    abstract::Ischemia and reperfusion injure the heart, as manifested by myocardial infarction, postischemic ventricular functional dysfunctions, arrhythmias, and cardiomyocyte apoptosis. Hearts can be adapted to ischemic-reperfusion injury by subjecting them to non-lethal cyclic episodes of short-term ischemia and reperfusion. Th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb09254.x

    authors: Maulik N,Sasaki H,Galang N

    更新日期:1999-06-30 00:00:00

  • Blood--its derivatives and its problems--factor VIII.

    abstract::Unfortunately, all of the problems of the hemophiliac have not been solved by the availability of concentrated factor VIII products. Patients still are faced with the crippling effects of arthritis, problems with employment, problems with ignorance (both medical and lay), and an increased risk of premature death even ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1975.tb53341.x

    authors: Breckenridge RT

    更新日期:1975-01-20 00:00:00

  • SPR imaging-based salivary diagnostics system for the detection of small molecule analytes.

    abstract::Saliva is an underused fluid with considerable promise for biomedical testing. Its potential is particularly great for monitoring small-molecule analytes since these are often present in saliva at concentrations that correlate well with their free levels in blood. We describe the development of a prototype diagnostic ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1384.026

    authors: Fu E,Chinowsky T,Nelson K,Johnston K,Edwards T,Helton K,Grow M,Miller JW,Yager P

    更新日期:2007-03-01 00:00:00

  • Vitamin A influence on calcium metabolism and calcification.

    abstract::Vitamin A deficiency has been shown to affect vision, reproduction, cellular differentiation, and maintenance of epithelial and skeletal tissues. Different vitamin A compounds, i.e., retinol and retinoic acid, vary in their ability to fulfill these biologic functions. Aside from vision, the exact molecular mechanisms ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1980.tb21326.x

    authors: Navia JM,Harris SS

    更新日期:1980-01-01 00:00:00

  • Chaos in the centers of galaxies.

    abstract::We compare diverging evolution of a two-component (gas+stars) galactic disk embedded in a "live" halo with that of an identical pure stellar disk. Our modeling supports the conjecture that the growth of central concentration in galaxies dissolves the main family of regular orbits in the stellar bar and assists in the ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb11258.x

    authors: Shlosman I,Heller C,Berentzen I

    更新日期:1998-12-30 00:00:00

  • Liquid surfactant membrane emulsions. A new technique for enzyme immobilization.

    abstract::Liquid membrane reactors are well known for metal extraction. This technology may also be applied to the immobilization of enzymes in enzyme emulsions. The use of liquid membrane reactors for enzymatic bioconversions has several advantages in comparison to solid membrane reactors and conventional immobilization techni...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1987.tb45702.x

    authors: Scheper T,Makryaleas K,Nowottny C,Likidis Z,Tsikas D,Schügerl K

    更新日期:1987-01-01 00:00:00

  • Antisense promoter mapping. Inhibitory methods of transcriptional analysis.

    abstract::We have employed antisense methods to study the transcriptional functions of c-fos protein (Fos). Clones expressing inducible anti-fos RNA have been employed to inhibit c-fos expression, resulting in activation of c-fos transcription by inhibiting its normal repressor function. The sites of negative regulation by Fos ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1992.tb21061.x

    authors: Holt JT

    更新日期:1992-10-28 00:00:00

  • Role of platelets and leukocytes in modulation of vascular tone.

    abstract::Activated platelets and leukocytes release potent vasoactive factors that may modulate vascular tone. Activation of normal platelets produces dilatation of normal arteries. Vasodilatation is mediated by adenosine diphosphate (ADP), which releases endothelium-derived relaxing factor (EDRF) from endothelium. In atherosc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1994.tb12036.x

    authors: Kaul S,Padgett RC,Heistad DD

    更新日期:1994-04-18 00:00:00

  • A cooperative study of sarcoidosis in Asia and Africa: analytic epidemiology.

    abstract::The characteristics of about 2,000 Japanese sarcoidosis cases collected by the Japan Sarcoidosis Committee during the 10-yr period, 1963-1972, were chronological increase with decreasing infectious diseases (represented by tuberculosis), north-to-south decline in sarcoidosis incidence in accordance with the Oxford Atl...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb47046.x

    authors: Hosoda Y,Hiraga Y,Odaka M,Yangawa H,Ito Y,Shiegematsu I,Chiba Y

    更新日期:1976-01-01 00:00:00

  • A unifying mechanism in the initiation of cancer and other diseases by catechol quinones.

    abstract::The first step in cancer initiation is the reaction of chemical carcinogens with DNA to form stable adducts, which remain in DNA unless removed by repair, and depurinating adducts, which detach from DNA following destabilization of the glycosyl bond. Depurinating DNA adducts of polycyclic aromatic hydrocarbons play a ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1322.029

    authors: Cavalieri EL,Rogan EG

    更新日期:2004-12-01 00:00:00

  • Hydrological cycle changes under global warming and their effects on multiscale climate variability.

    abstract::Despite a globally uniform increase in the concentrations of emitted greenhouse gases, radiatively forced surface warming can have significant spatial variations. These define warming patterns that depend on preexisting climate states and through atmospheric and oceanic dynamics can drive changes of the hydrological c...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14335

    authors: Ma J,Zhou L,Foltz GR,Qu X,Ying J,Tokinaga H,Mechoso CR,Li J,Gu X

    更新日期:2020-07-01 00:00:00

  • Amplified MYCN in human neuroblastoma: paradigm for the translation of molecular genetics to clinical oncology.

    abstract::Increase in the dosage of cellular oncogenes by DNA amplification is a frequent genetic alteration of cancer cells. In neuroblastoma, amplification of the gene MYCN has been associated with aggressively growing cancers and is an indicator for poor prognosis. MYCN amplification is of predictive value in identifying pat...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:

    authors: Schwab M

    更新日期:2002-06-01 00:00:00

  • Fish health--some concepts, constraints, and comparisons.

    abstract::This has been an overview of fish health, a comparison of some aspects of fish husbandry with other animal husbandry, and comments concerning fish health research--especially where it is going. The 1972 disease survey identified current problems; it ranked the problems according to priority. More important, research e...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1975.tb26826.x

    authors: Wolf K

    更新日期:1975-01-24 00:00:00

  • Neurobiology of addiction. Toward the development of new therapies.

    abstract::Drug addiction is a chronic relapsing brain disorder characterized by neurobiological changes that lead to a compulsion to take a drug with loss of control over drug intake. The hypothesis outlined here is that knowledge of the neurochemical systems involved in the transition from drug use to the compulsive use of add...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb06682.x

    authors: Koob GF

    更新日期:2000-01-01 00:00:00