当前位置： SCI文献检索 > JOURNAL OF PEDIATRIC SURGERY期刊下所有文献 > Effect of epidermal growth factor infusion on fetal rabbit intrauterine growth retardation and small intestinal development.

Effect of epidermal growth factor infusion on fetal rabbit intrauterine growth retardation and small intestinal development.

Abstract：

BACKGROUND/PURPOSE:Intrauterine growth retardation (IUGR) infants have impaired gastrointestinal function with resultant feeding difficulties and predisposition to necrotizing enterocolitis. Supplemented amniotic fluid swallowed by the developing fetus is a potential prenatal treatment for IUGR. Rabbits have naturally occurring IUGR fetuses based on uterine position. To determine intestinal response to epidermal growth factor (EGF) infusion, this rabbit model of IUGR was studied. METHODS:Eight pregnant rabbits underwent placement of intraamniotic catheters into 2 normal and 2 IUGR fetuses per mother on gestational day 24 of a 31-day gestation. Miniosmotic pumps infused either EGF (about 300 microg/kg/d) or control solution forming 4 study groups (EGF-Favored [Fav] v. Cont-Fav; EGF-IUGR v. Cont-IUGR). On gestational day 31, the fetal gastrointestinal tracts were harvested for analysis. Intestinal epithelial cell proliferation was studied by 5-bromo-2-deoxyuridine (BrdU) incorporation, villus heights were measured, and EGF mRNA was measured by reverse transcriptase polymerase chain reaction (RT-PCR). Statistical analysis was performed using Students' t test. RESULTS:Fetal survival rate was 87%. EGF-IUGR fetal weights were increased compared with Cont-IUGR fetuses. EGF infusion significantly increased IUGR fetal small intestinal villus height and BrdU-positive small intestinal (SI) crypt cells, all approaching Cont-Fav levels. EGF mRNA was expressed throughout the gastrointestinal tract. CONCLUSIONS:Supplemental amniotic EGF normalizes fetal weight and intestinal proliferation in the IUGR fetal rabbit. The inclusion of EGF in supplemental amniotic feeding solutions is supported.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Cellini C,Xu J,Arriaga A,Buchmiller-Crair TL

doi

10.1016/j.jpedsurg.2004.02.008

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

891-7; discussion 891-7

issue

6

eissn

0022-3468

issn

1531-5037

pii

S0022346804000910

journal_volume

39

pub_type

杂志文章

相关文献

JOURNAL OF PEDIATRIC SURGERY文献大全
  • Resource utilization and indications for helicopter transport of head-injured children.

    abstract：INTRODUCTION:Helicopter emergency medical services (HEMS) have provided benefit for severely injured patients. However, HEMS are likely overused for the transportation of both adult and pediatric trauma patients. In this study, we aim to evaluate the degree of overuse of helicopter as a mode of transport for head-injur...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2018.04.032

    authors： Elswick CM,Wyrick D,Gurien LA,Rettiganti M,Gowen M,Pownall A,Bahgat D,Maxson RT,Öcal E,Albert GW

    更新日期：2018-09-01 00:00:00

  • Discordant prenatal ultrasound and fetal MRI in CDH: wherein lies the truth?

    abstract：PURPOSE:Prenatal risk assessment of congenital diaphragmatic hernia (CDH) relies on prenatal ultrasound (U/S) and fetal magnetic resonance imaging (MRI). When the modalities differ in prognosis, it is unclear which is more reliable. METHODS:Retrospective chart review identified cases of prenatally diagnosed CDH from 4...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2019.11.007

    authors： Kim AG,Norwitz G,Karmakar M,Ladino-Torres M,Berman DR,Kreutzman J,Treadwell MC,Mychaliska GB,Perrone EE

    更新日期：2020-09-01 00:00:00

  • Port insertion and removal techniques to minimize premature rupture of the membranes in endoscopic fetal surgery.

    abstract：BACKGROUND:Premature rupture of membranes (PROM) remains a significant complication of fetal surgery. Rates of 40% to 100% have been reported after both open and endoscopic fetal surgery. We describe a technique of endoscopic port insertion and removal that minimizes trauma to the membranes. METHODS:Twenty-seven conse...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2006.01.006

    authors： Chang J,Tracy TF Jr,Carr SR,Sorrells DL Jr,Luks FI

    更新日期：2006-05-01 00:00:00

  • Does peritoneal lavage influence the rate of complications following pediatric Laparoscopic Appendicectomy in Children with Complicated Appendicitis? A Prospective Randomized Clinical Trial.

    abstract：BACKGROUND:There is ongoing debate concerning the use of peritoneal irrigation in the setting of complicated appendicitis (CA) in children. Our aim was to conduct a prospective randomized controlled trial for the treatment of CA during a laparoscopic appendicectomy in children. METHODS:Following ethical approval (REC1...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jpedsurg.2019.08.039

    authors： Nataraja RM,Panabokke G,Chang AD,Mennie N,Tanny ST,Keys C,Cheng W,Pacilli M,Ferguson P

    更新日期：2019-12-01 00:00:00

  • Understanding translational research: a play in four acts.

    abstract：:Translational research (TR) bridges discovery to clinical delivery. All TR also requires the development of an intervention. Classical 'bench to bedside' TR is responsible for many important advances, but cannot account for many others, which begin with clinical observations. My personal involvement in TR has ranged f...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2014.10.023

    authors： Rose EA

    更新日期：2015-01-01 00:00:00

  • Lambert-Eaton myasthenic syndrome revealing an abdominal neuroblastoma.

    abstract：:Lambert-Eaton myasthenic syndrome is a paraneoplastic syndrome that may reveal a primitive tumor. Neuroblastoma in children and small cell lung carcinoma in adults are the leading tumors revealed or expressed by paraneoplastic phenomena. The clinical neurologic manifestations of Lambert-Eaton myasthenic syndrome are m...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2009.04.023

    authors： de Buys Roessingh AS,Loriot MH,Wiesenauer C,Lallier M

    更新日期：2009-08-01 00:00:00

  • Management of nonparasitic splenic cysts in children: A French multicenter review of 100 cases.

    abstract：BACKGROUND:The management of nonparasitic splenic cysts (NPSC) remains controversial. Surgical resection is indicated for symptomatic or complicated forms, but no guidelines are available for asymptomatic NPSC. The aims of this study were to evaluate the management of NPSC in French hospitals and to analyze the results...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jpedsurg.2017.01.054

    authors： Delforge X,Chaussy Y,Borrego P,Abbo O,Sauvat F,Ballouhey Q,Irtan S,Arnaud A,Ibtissam K,Panait N,Rodesch G,Steyaert H,Schneider A,Dubois R,Mesureur S,Haraux E,Buisson P

    更新日期：2017-09-01 00:00:00

  • Neonatal care in patients with giant ompholocele: arduous management but favorable outcomes.

    abstract：OBJECTIVES:The objectives of the study were to provide a review of patients with giant omphalocele managed in a single institution (2001-2006), focusing on medical management in the neonatal period, and to evaluate short-term outcomes. METHODS:Data from 14 neonates with giant ompholocele (abdominal wall defect >5 cm a...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2010.04.011

    authors： Mitanchez D,Walter-Nicolet E,Humblot A,Rousseau V,Revillon Y,Hubert P

    更新日期：2010-08-01 00:00:00

  • Sensorineural hearing loss in congenital diaphragmatic hernia survivors is associated with postnatal management and not defect size.

    abstract：BACKGROUND/PURPOSE:We determined the incidence of sensorineural hearing loss (SNHL; >20dB at any frequency) in a contemporary cohort of congenital diaphragmatic hernia (CDH) survivors at a single tertiary care center and identified potential risk factors for SNHL. METHODS:From 2000 through 2011, clinical and audiologi...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2014.01.049

    authors： Dennett KV,Fligor BJ,Tracy S,Wilson JM,Zurakowski D,Chen C

    更新日期：2014-06-01 00:00:00

  • Octreotide for chylous effusions in congenital diaphragmatic hernia.

    abstract：BACKGROUND/PURPOSE:Chylothorax is a frequent complication in congenital diaphragmatic hernia (CDH) infants and is associated with significant morbidity. The optimal treatment strategy remains unclear. We hypothesize that octreotide decreases chylous effusions in infants with CDH. METHODS:This is a retrospective study ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2013.05.064

    authors： Landis MW,Butler D,Lim FY,Keswani S,Frischer J,Haberman B,Kingma PS

    更新日期：2013-11-01 00:00:00

  • Congenital esophageal diverticulum - a case report and review of literature.

    abstract：:Zenker's Diverticulum (ZD) is a false diverticulum located in the posterior esophagus between the cricopharyngeus and inferior constrictor. Few cases have been reported in the pediatric population. Congenital esophageal diverticulum is commonly associated with additional esophageal anatomical deformities or iatrogenic...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpedsurg.2012.12.037

    authors： Lindholm EB,Hansbourgh F,Upp JR Jr,Cilloniz R,Lopoo J

    更新日期：2013-03-01 00:00:00

  • Posterior urethral valves: creatinine velocity, a new early predictor of renal insufficiency.

    abstract：AIM:Antenatal screening has led to early detection of posterior urethral valves (PUV). However, despite early intervention, a proportion of children will develop chronic renal insufficiency. We studied the trend of serum creatinine following urinary tract decompression during the neonatal period in infants as a possibl...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2012.11.016

    authors： Coleman R,King T,Nicoara CD,Bader M,Chandran H,Robb A,Parashar K

    更新日期：2013-02-01 00:00:00

  • A method for recovering a lost retrieval line under direct vision in children with esophageal strictures.

    abstract：:Loss of a retrieval line for repeated esophageal dilations for caustic esophageal stricture may result in inability to dilate these strictures. We describe a simple means for retrieving such a line once it has been removed. ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(88)80145-3

    authors： Mercer CD,Hall SF,Kerr JW

    更新日期：1988-02-01 00:00:00

  • Hepatic artery transection after blunt trauma: case presentation and review of the literature.

    abstract：:Hepatic artery injuries sustained as a result of blunt abdominal trauma are rare. This case represents the first reported hepatic artery transection and the second hepatic artery injury described in children. Hepatic artery injuries are associated with high mortality, and their management is complex and controversial....

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpedsurg.2006.05.001

    authors： Miglietta MA,Moore JA,Bernstein MP,Frangos SG,Ginsburg H,Pachter HL

    更新日期：2006-09-01 00:00:00

  • Does the current health care environment contribute to increased morbidity and mortality of acute appendicitis in children?

    abstract：:To determine whether the current "gatekeeper" controls on health care lead to an increase in treatment delay and morbidity of acute appendicitis in children, we reviewed the experience with this disease at a large children's hospital over a 10-year period. One hundred seven consecutive children 18 years and younger op...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/0022-3468(93)90225-a

    authors： Linz DN,Hrabovsky EE,Franceschi D,Gauderer MW

    更新日期：1993-03-01 00:00:00

  • Congenital pancreatic pseudocyst: report of two cases.

    abstract：:Pancreatic pseudocysts have not been reported to occur in the fetus or newborn. The authors report two cases of histologically proven pancreatic pseudocysts in neonates, which were detected using prenatal ultrasonography. Surgical management included external marsupialization followed by internal drainage in one case,...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(96)90185-2

    authors： Kurrer MO,Ternberg JL,Langer JC

    更新日期：1996-11-01 00:00:00

  • Esophageal atresia. Lessons I have learned in a 40-year experience.

    abstract：:A brief resume of the highlights in the history of oesophageal atresia is presented. This is followed by research into the etiology, ontogeny and embryology, and microbiological studies. A revised classification of risk factors with consequent survival statistics is presented. Lessons learned in the management of the ...

    journal_title：Journal of pediatric surgery

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.jpedsurg.2006.07.004

    authors： Spitz L

    更新日期：2006-10-01 00:00:00

  • Single-incision laparoscopic-assisted anorectoplasty using conventional instruments for children with anorectal malformations and rectourethral or rectovesical fistula.

    abstract：BACKGROUND:This study aims to evaluate the safety and efficacy of single-incision laparoscopic-assisted anorectoplasty (SILAARP) for children with anorectal malformations (ARM) and rectourethral or rectovesical fistula. METHODS:Children with ARMs and rectourethral or rectovesical fistula who underwent SILAARP between ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2014.08.010

    authors： Diao M,Li L,Ye M,Cheng W

    更新日期：2014-11-01 00:00:00

  • Benefit of early inflow exclusion during living donor liver transplantation for unresectable hepatoblastoma.

    abstract：BACKGROUND:Hepatoblastoma (HB) is a highly malignant primary liver tumor in children. Although liver transplantation (LT) is an effective treatment for unresectable HB with good long-term outcomes, post-transplant survival is mainly affected by recurrence, despite adjuvant chemotherapy. Novel strategies are needed to i...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2016.04.021

    authors： Uchida H,Fukuda A,Sasaki K,Hirata Y,Shigeta T,Kanazawa H,Nakazawa A,Miyazaki O,Nosaka S,Mali VP,Sakamoto S,Kasahara M

    更新日期：2016-11-01 00:00:00

  • Selective inhibition of cyclooxygenase-2 suppresses metastatic disease without affecting primary tumor growth in a murine model of Ewing sarcoma.

    abstract：BACKGROUND/PURPOSE:Mammalian target of rapamycin suppression by rapamycin inhibits tumor growth and neovascularization via cyclooxygenase-2 (COX-2) downregulation with no effect on lung metastases. We hypothesize that combining a selective COX-2 antagonist (celecoxib) with rapamycin would decrease lung metastases. MET...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2010.09.074

    authors： Gendy AS,Lipskar A,Glick RD,Steinberg BM,Edelman M,Soffer SZ

    更新日期：2011-01-01 00:00:00

  • Comparison of long-term outcomes between open and laparoscopic Thal fundoplication in children.

    abstract：OBJECTIVES:In recent years laparoscopic fundoplication is increasingly performed in pediatric surgery. The aim of this study was to compare the long-term outcomes between open and laparoscopic Thal fundoplication in children. METHODS:This retrospective study includes children who underwent a Thal fundoplication betwee...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2014.02.077

    authors： Kubiak R,Böhm-Sturm E,Svoboda D,Wessel LM

    更新日期：2014-07-01 00:00:00

  • Effects of irradiated tumor vaccine and continuous localized infusion of granulocyte-macrophage colony-stimulating factor on neuroblastomas in mice.

    abstract：BACKGROUND/PURPOSE:Immunomodulatory treatment has been proposed as a feasible strategy for neuroblastoma treatment. In this study, the antitumor effects of a continuous localized subcutaneous infusion of granulocyte-macrophage colony-stimulating factor (GM-CSF) into the injection site of irradiated tumor vaccine used a...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1053/jpsu.2002.34995

    authors： Chen Y,Lin SM,Lai HS,Tseng SH,Chen WJ

    更新日期：2002-09-01 00:00:00

  • Laparoscopic cholecystecomy in a 16-day-old infant with chronic cholelithiasis.

    abstract：:A 16-day-old girl with demonstrated evidence of cholelithiasis was treated initially conservatively on the assumption that the gallstone would resolve spontaneously. However, when repeat ultrasound scan showed a large gallstone and intrahepatic ductal dilatation indicative of antenatal common duct obstruction, the inf...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpedsurg.2003.09.034

    authors： Gertner M,Farmer DL

    更新日期：2004-01-01 00:00:00

  • Evolution and Outcomes of a Canadian Pediatric Bariatric Surgery Program.

    abstract：PURPOSE:An interdisciplinary obesity management program was established in 2007 at our quaternary hospital, including bariatric surgery for selected adolescent patients. We report the evolution of surgical management within the program and outcomes following bariatric surgery. METHODS:This was a retrospective review o...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2019.01.038

    authors： Akinkuotu AC,Hamilton JK,Birken C,Toulany A,Strom M,Noseworthy R,Hagen J,Dettmer E,Langer JC

    更新日期：2019-05-01 00:00:00

  • Abscess of the mediastinum: a case report.

    abstract：:In this report a rare case of mediastinal abscess secondary to purulent tonsilitis is reported. Generally this condition is consequent to systemic, cervical, thoracic, or abdominal infections. ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(89)80090-9

    authors： Komatsu ES,Costa F,Marchese LT,Villari Filho S

    更新日期：1989-11-01 00:00:00

  • Necrosis of the ileum in a diabetic adolescent.

    abstract：:A 17-year-old boy with insulin-dependent diabetes mellitus developed ketoacidosis and transitory shock. After resolution of his metabolic imbalance, he developed an acute abdomen prompting exploratory surgery. A section of necrotic ileum was found and resected. ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/0022-3468(92)90798-c

    authors： Chan-Cua S,Jones KL,Lynch FP,Freidenberg GR

    更新日期：1992-09-01 00:00:00

  • Tissue plasminogen activator for the treatment of intraabdominal abscesses in a neonate.

    abstract：:Fibrinolytic agents have been used successfully in the management of loculated empyema; however, their use in the treatment of intraabdominal abscesses is limited. The authors describe the case of a 4-week-old girl with intraabdominal abscesses secondary to intestinal perforation that were not amenable to percutaneous...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(03)00275-6

    authors： Diamond IR,Wales PW,Connolly B,Gerstle T

    更新日期：2003-08-01 00:00:00

  • Choledochopancreatic elongated common channel disorders.

    abstract：:A choledochopancreatic end-to-side ductal anastomosis was successfully performed in 40 puppies as an experimental animal model of choledochopancreatic elongated common channel disorders. Follow-up periods were up to 1 year after surgery. Fusiform dilatation was developed in all puppies. The dilatation was completed wi...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(84)80439-x

    authors： Miyano T,Suruga K,Shimomura H,Nittono H,Yamashiro Y,Matsumoto M

    更新日期：1984-04-01 00:00:00

  • Preliminary evidence that cell death may contribute to separation of the trachea from the primitive foregut in the rat embryo.

    abstract：BACKGROUND/PURPOSE:The embryogenesis of many congenital tracheoesophageal abnormalities has been elucidated poorly, mainly because of an incomplete understanding of the normal mechanism of separation of the primitive foregut into the trachea and esophagus. There has been controversy about the existence and significance...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(98)90604-2

    authors： Qi BQ,Beasley SW

    更新日期：1998-11-01 00:00:00

  • Laparoscopic ovarian tissue preservation in young patients at risk for ovarian failure as a result of chemotherapy/irradiation for primary malignancy.

    abstract：BACKGROUND:Aggressive chemotherapy/radiotherapy for cancer may cause gonadal failure in young female survivors. The putative aim of ovarian tissue cryopreservation is to restore fertility by transplantation of a patient's frozen-thawed ovarian tissue or, further into the future, by in vitro maturation of frozen-thawed ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2006.12.041

    authors： Feigin E,Abir R,Fisch B,Kravarusic D,Steinberg R,Nitke S,Avrahami G,Ben-Haroush A,Freud E

    更新日期：2007-05-01 00:00:00