Understanding translational research: a play in four acts.

Abstract:

:Translational research (TR) bridges discovery to clinical delivery. All TR also requires the development of an intervention. Classical 'bench to bedside' TR is responsible for many important advances, but cannot account for many others, which begin with clinical observations. My personal involvement in TR has ranged from exploration of long-term mechanical circulatory support devices to amelioration of the progression of Alzheimer's disease to the pharmacologic cure of smallpox. This experience suggests that most TR is opportunistic and inefficient. A strategic approach to TR based on a better understanding of the processes it entails could enhance progress in TR despite its increasing complexity.

journal_name

J Pediatr Surg

authors

Rose EA

doi

10.1016/j.jpedsurg.2014.10.023

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

37-43

issue

1

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(14)00673-3

journal_volume

50

pub_type

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