Abstract:
:Forty-eight healthy adults aged 65-85 were recruited for structural magnetic resonance scans after an extensive neuropsychological battery that ensured a high degree of variability across the sample in performance on long-term memory tests, and on tests traditionally thought to rely on prefrontal cortex. Gray matter volumes were measured for three gyri in the frontal lobe (superior, middle, inferior), six gyri in the temporal lobe (superior, middle, inferior, fusiform, parahippocampal, and hippocampus), and the occipital lobe. Gray matter volumes declined across the age range evaluated, but with substantial regional variation--greatest in the inferior frontal, superior temporal, and middle temporal gyri but negligible in the occipital lobe. Both memory performance and executive function declined as the number of hyperintense regions in the subcortical white matter increased. Memory performance was also significantly correlated with gray matter volumes of the middle frontal gyrus (MFG), and several regions of temporal neocortex. However, the correlations were all in the negative direction; better memory performance was associated with smaller volumes. Several previous reports of significant negative correlations between gray matter volumes and memory performance are described, so that the possible reasons for this surprising finding are discussed.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Van Petten C,Plante E,Davidson PS,Kuo TY,Bajuscak L,Glisky ELdoi
10.1016/j.neuropsychologia.2004.02.009subject
Has Abstractpub_date
2004-01-01 00:00:00pages
1313-35issue
10eissn
0028-3932issn
1873-3514pii
S0028393204000508journal_volume
42pub_type
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