Abstract:
:This study investigates reproductive impairment and biochemical changes in fathead minnow (Pimephales promelas) exposed for 39 d to varying concentrations of perfluorooctanoic acid (PFOA) under microcosm conditions. While the concentrations tested in this study were much higher than those normally found in the environment, no mortality was associated with PFOA exposure. Only modest changes were observed in condition factor and in relative liver and gonad size. Significant declines in circulating plasma steroids were observed, but these were accompanied by only limited increases in time to first oviposition and decreases in overall egg production. Peroxisome proliferation, as quantified by fatty acyl-CoA oxidase (FAO) activity, was elevated with low PFOA concentrations but attenuated with exposure to higher PFOA doses. Little evidence was seen of differential induction of peroxisome-associated enzyme activity with sex. Oxidative stress, as quantified by the 2-thiobarbituric acid reactive substances (TBARS) assay, was only modestly influenced by PFOA exposure and is not a significant consequence of FAO activity in fathead minnow. Perfluorooctanoic acid appears to be relatively nontoxic at environmentally relevant concentrations but may impact biochemical and reproductive endpoints under conditions associated with environmental spills.
journal_name
Environ Toxicol Chemjournal_title
Environmental toxicology and chemistryauthors
Oakes KD,Sibley PK,Solomon KR,Mabury SA,Van der Kraak GJdoi
10.1897/03-190subject
Has Abstractpub_date
2004-08-01 00:00:00pages
1912-9issue
8eissn
0730-7268issn
1552-8618journal_volume
23pub_type
杂志文章abstract::Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that has been detected widely in surface waters in North America and Europe. The impact of diclofenac on river biofilm communities was investigated at exposures of 10 and 100 microg L(-1) of diclofenac or its molar equivalent in carbon and nutrients. Experime...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/06-340r.1
更新日期:2007-04-01 00:00:00
abstract::Many habitats may be exposed to multiple chemical contaminants, particularly in agricultural areas where fertilizer and pesticide use are common; however, the singular and interactive effects of contaminants are not well understood. The objective of our study was to examine how realistic, sublethal environmental level...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/04-319r.1
更新日期:2005-05-01 00:00:00
abstract::Some toxicology research in which toxicant exposures are continual (pulsed) rather than continuous have been reported. A number of toxicity models have been developed for pulsed and continuous exposures. Most of these models were developed based on one- or two-compartment, first-order toxicokinetics and were calibrate...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/06-081r.1
更新日期:2007-01-01 00:00:00
abstract::We studied the influence of sediment geochemistry on bioavailability of As, Cd, and Cr in deposit-feeding polychaetes. Metal phase speciation in sediments was determined with a sequential extraction scheme, and assimilation efficiencies (AEs) of ingested metals were determined by pulse-chase feeding experiments using ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.436
更新日期:2011-03-01 00:00:00
abstract::The photodegradation rate of the anti-histamine cetirizine (Zyrtec®) was investigated in various water matrices. The average observed first-order photodegradation rate coefficient (kobs ), obtained by linear regression of the logarithmic-transformed cetirizine concentrations versus irradiation time in simulated sunlig...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.2691
更新日期:2014-10-01 00:00:00
abstract::The present study determined concentrations of estrogenic bisphenol A (BPA), nonylphenol, octylphenol (4-tert-octylphenol), butylphenol (4-tert-butylphenol), and progestogenic norethindrone by liquid chromatography-tandem mass spectrometry in bile extracts from field fish from the Xin'an River and market fish in Shang...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3176
更新日期:2016-01-01 00:00:00
abstract::Mercury (Hg) contamination of aquatic ecosystems is a global environmental problem. Data are abundant on Hg contamination and factors that affect its bioaccumulation in lake communities, but comparatively little information on riverine ecosystems exists. The present study examines fish Hg concentrations of the Lower R...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.224
更新日期:2010-08-01 00:00:00
abstract::The present study evaluated the use of the invasive clam Corbicula fluminea as a surrogate for metal accumulation in native mussels. The tissue concentrations of As, Cd, Cu, Hg, Mn, Ni, Pb, and Zn were analyzed in Corbicula and a native Unionid mussel species (Elliptio hopetonensis) collected from 13 sites in the Alta...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.235
更新日期:2010-09-01 00:00:00
abstract::The use of passive sampling devices (PSDs) for monitoring hydrophobic organic contaminants in aquatic environments can entail logistical constraints that often limit a comprehensive statistical sampling plan, thus resulting in a restricted number of samples. The present study demonstrates an approach for using the res...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.2014
更新日期:2012-12-01 00:00:00
abstract::Freshwater organisms are increasingly exposed to combinations of stressors. However, because it is time-consuming and costly, research on the interaction of stressors, such as compound toxicity and global warming on vertebrates, is scarce. Studies on multigenerational effects of these combined stressors are almost non...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4182
更新日期:2018-09-01 00:00:00
abstract::The effects of salinity, gender, and development on the acute toxicity of aldicarb were examined in the euryhaline fish, Japanese medaka (Oryzias latipes). The 96-h median lethal concentrations (LC50s) at 1.5 parts per thousand (per thousand) salinity were not significantly different between adults and juveniles but l...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract::Heavy metals can cause a decrease in the taxonomic diversity of soil communities. Because of functional redundancy, it remains unclear to what extent different functions performed by the soil microbial communities may be affected by pollution. We studied the impact of metal contamination on soil bacterial and fungal f...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/07-288.1
更新日期:2008-03-01 00:00:00
abstract::The toxicity of nitroaromatic (2,4-diaminonitrotoluene [2,4-DANT] and 1,3,5-trinitrobenzene [TNB]) and 14C-labeled cyclonitramine compounds (hexahydro-1,3,5-trinitro-1,3,5-triazine [RDX] and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine [HMX]) to the marine polychaete Neanthes arenaceodentata and the estuarine amph...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract::Extensive season-by-season sampling was used to establish the normal range of whole-body Na+ and Cl- and Na+ uptake in healthy populations of two fish species, rainbow trout, Oncorhynchus mykiss, and fathead minnow, Pimephales promelas, of known differences in sensitivity to ionoregulatory toxicants (low pH, trace met...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract::A statewide investigation of insecticide presence and sediment toxicity was conducted in Illinois, USA, from June to August 2008. Twenty sediment samples were collected from urban areas throughout Illinois, and 49 sediment samples were collected from 14 agriculture-dominated counties in central and southern Illinois. ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.13
更新日期:2010-01-01 00:00:00
abstract::Amphibian population declines have been documented worldwide and environmental contaminants are believed to contribute to some declines. Maternal transfer of bioaccumulated contaminants to offspring may be an important and overlooked mechanism of impaired reproductive success that affects amphibian populations. Mercur...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.125
更新日期:2010-04-01 00:00:00
abstract::A combination of forward and reverse heteronuclear ((19)F/(1)H) saturation transfer difference (STD) nuclear magnetic resonance (NMR) spectroscopic techniques were applied to characterize the noncovalent interactions between perfluorinated aromatic xenobiotics and dissolved humic acid. These NMR techniques produce det...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.560
更新日期:2011-08-01 00:00:00
abstract::A major problem with risk assessment of chemicals is the extrapolation of laboratory single-species toxicity tests, which oversimplify the actual field situation by ignoring species interactions, to natural communities. The authors tested if the bioavailability-normalized 5% hazardous concentration (HC5) estimated fro...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3435
更新日期:2016-11-01 00:00:00
abstract::Deposit-feeders may be important in facilitating the removal of organic contaminants from bulk sediment. The relationship between uptake route (water vs sediment), depuration and toxicity was investigated in the deposit-feeding polychaete Capitella species I. Individual worms were exposed either to dissolved (i.e., < ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/02-271
更新日期:2003-10-01 00:00:00
abstract::Laboratory bioassays were conducted to evaluate the effects on honeybee behavior of sublethal doses of insecticides chronically administered orally or by contact. Emergent honeybees received a daily dose of insecticide ranging from one-fifth to one-five-hundredth of the median lethal dose (LD50) during 11 d. After exp...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/08-110.1
更新日期:2009-01-01 00:00:00
abstract::Diluted bitumen (dilbit; the product of oil sands extraction) is transported through freshwater ecosystems critical to Pacific salmon. This is concerning, because crude oil disrupts cardiac development, morphology, and function in embryonic fish, and cardiac impairment in salmon can have major consequences on migrator...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3533
更新日期:2017-02-01 00:00:00
abstract::In vitro metabolic stability assays using rainbow trout (Oncorhynchus mykiss) isolated hepatocytes (RT-HEP) or hepatic S9 fractions (RT-S9) were introduced to provide biotransformation rate data for the assessment of chemical bioaccumulation in fish. The present study explored the suitability of the RT-HEP and RT-S9 a...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4872
更新日期:2020-12-01 00:00:00
abstract::Understanding the environmental risks of pharmaceuticals and personal care products (PPCPs) has become very important in the field of aquatic toxicology. Hydroxylpropyl-β-cyclodextrin (HPβCD) is an amphiphilic, toroidal shaped molecule with the ability to form noncovalent inclusion complexes with a variety of guest mo...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3280
更新日期:2016-06-01 00:00:00
abstract::The ability of Spartina alterniflora to degrade tributyltin (TBT) in contaminated dredge spoils was investigated in a created wetland at Little Creek Naval Amphibious Base in Norfolk, Virginia, USA. Concentrations of TBT up to 250 ng/g did not inhibit S. alterniflora growth over a 16-month period. Disappearance rates ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract::Ab initio gene prediction and evidence alignment were used to produce the first annotations for the fathead minnow (Pimephales promelas) genome. We also describe a genome browser, hosted by the Society of Environmental Toxicology and Chemistry, that provides simplified access to the annotation data in context with the...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3929
更新日期:2017-12-01 00:00:00
abstract::Acute and chronic toxicity of high-grade chlordane (98%) and bioaccumulation were investigated in Daphnia magna at water soluble concentrations obtained without cosolvent. The measured effective concentrations immobilizing 50% of the microcrustacea (95% confidence interval) were 22.6 (19.7-26.1) microg/L at 24 h and 1...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/08-564.1
更新日期:2009-10-01 00:00:00
abstract::On the quantitative comparison of solubilities or vapor pressures of homologous series, the variation in the effect of crystal structure on solid properties may substantially influence the outcome of the comparison. Usually, the effect of this variation is eliminated by comparing values of the liquid state. The ratio ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/06-083r.1
更新日期:2006-11-01 00:00:00
abstract::Octanol-water partition coefficients (KOW ) are widely used in fate and effects modeling of chemicals. Still, high-quality experimental KOW data are scarce, in particular for very hydrophobic chemicals. This hampers reliable assessments of several fate and effect parameters and the development and validation of new mo...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3300
更新日期:2016-06-01 00:00:00
abstract::Toxicity of cadmium to early life stages of brown trout (Salmo trutta) was determined at multiple water hardnesses. Increasing water hardness decreased cadmium toxicity. Postswimup fry were much more sensitive than embryos and larvae. Chronic values from early life stage tests initiated with eyed embryos were 3.52, 6....
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/06-376r.1
更新日期:2007-08-01 00:00:00
abstract::Biodegradation of trichloroethylene (TCE) by toluene-degrading bacteria was measured under aerobic conditions in aqueous and soil-slurry batch microcosms. For soil-phase experiments, a freshly contaminated soil and a soil containing only the desorption-resistant fraction of TCE were tested. In both cases, presence of ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00