Abstract：
:Some toxicology research in which toxicant exposures are continual (pulsed) rather than continuous have been reported. A number of toxicity models have been developed for pulsed and continuous exposures. Most of these models were developed based on one- or two-compartment, first-order toxicokinetics and were calibrated with organic compounds. In the present study, the relationship between mortality (after 21 d) of Daphnia magna in response to pulsed and continuous exposures to Cu, Zn, and Se was used to develop a model that integrated the effects of single and multiple pulsed metal exposures based on first-order uptake and depuration kinetics. Mortality was a function of exposure concentration, duration, and recovery time between exposures. The model was successfully validated using an independent data set. It is applicable to risk assessment and, potentially, may be incorporated with other models (e.g., the biotic ligand model) to predict the toxicity of pulsed metal exposures under a range of environmental conditions.
journal_name
Environ Toxicol Chemjournal_title
Environmental toxicology and chemistryauthors
Hoang TC,Tomasso JR,Klaine SJdoi
10.1897/06-081r.1subject
Has Abstractpub_date
2007-01-01 00:00:00pages
132-8issue
1eissn
0730-7268issn
1552-8618journal_volume
26pub_type
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