Abstract：
:The influence of antimicrobial agents approved as veterinary drugs in Japan on the growth of green algae, Selenastrum capricornutum and Chlorella vulgaris, was studied in accordance with the OECD guidelines for testing chemicals. Among the agents tested, growth inhibitory activity was very varied, i.e. erythromycin showed the strongest activity (EC50, 50% effective concentration, = 0.037 mg/l), sulfa drugs had activity to some extent (EC50s of sulfamethoxazole, sulfadiazine, and sulfadimethoxine were 1.5, 2.2, and 2.3 mg/l, respectively), but ampicillin and cefazolin did not inhibit growth (EC50s>1000 mg/l). We also investigated synergistic effect of combining sulfa drugs with trimethoprim or pyrimethamine, which are commonly used as a combined drug. By adding trimethoprim, the growth inhibitory activity of sulfamethoxazole and sulfadiazine was significantly enhanced. Growth inhibition by sulfa drugs was reduced by the addition of folic acid, indicating that they inhibit folate synthesis in green algae.
journal_name
Chemospherejournal_title
Chemosphereauthors
Eguchi K,Nagase H,Ozawa M,Endoh YS,Goto K,Hirata K,Miyamoto K,Yoshimura Hdoi
10.1016/j.chemosphere.2004.07.017subject
Has Abstractpub_date
2004-12-01 00:00:00pages
1733-8issue
11eissn
0045-6535issn
1879-1298pii
S0045-6535(04)00604-6journal_volume
57pub_type
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