Chediak-Higashi syndrome in pregnancy.

Abstract:

:We report the first known case of Chediak-Higashi syndrome in human pregnancy. This rare autosomal recessive disorder is characterized by partial oculocutaneous albinism, decreased leukocyte chemotaxis, susceptibility to infection, and death in childhood. Pathognomonic giant cytoplasmic granules are postulated to be dysfunctional fused lysosomes, which influence a wide range of physiologic processes. Pregnancy did not seem to exert any influence on the course of the disease. The pregnancy, labor, and delivery were not affected and the infant and placenta were normal.

journal_name

Obstet Gynecol

authors

Price FV,Legro RS,Watt-Morse M,Kaplan SS

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

804-6

issue

5 ( Pt 2)

eissn

0029-7844

issn

1873-233X

journal_volume

79

pub_type

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