Abstract:
:Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication after hematopoietic stem cell or solid organ transplantation. The majority of PTLD is of B-cell origin and associated with Epstein-Barr virus (EBV). During the past decade progress has been made in better understanding the pathogenesis of PTLD, and early detection strategies, such as serial measurement of EBV-DNA load in peripheral blood samples, have assisted in the identification of high-risk patients. In addition, novel immunotherapies have been developed, including the use of monoclonal antibodies and adoptive transfer of EBV-specific T cells. Despite these advances, it remains a major challenge to define indications for preemptive therapies for PTLD and to integrate novel therapeutic approaches with conventional therapies.
journal_name
Annu Rev Medjournal_title
Annual review of medicineauthors
Gottschalk S,Rooney CM,Heslop HEdoi
10.1146/annurev.med.56.082103.104727subject
Has Abstractpub_date
2005-01-01 00:00:00pages
29-44eissn
0066-4219issn
1545-326Xjournal_volume
56pub_type
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