Benzodiazepine-induced intestinal motor disturbances in rats: mediation by omega 2 (BZ2) sites on capsaicin-sensitive afferent neurones.

abstract：:1. A study has been made of serum, mixed and parotid salivary levels attained in normal volunteers following oral dosage of 500 mg phenoxymethylpenicillin tablets, 500 mg crushed phenoxymethylpenicillin tablets in capsules, 500 mg ampicillin, 500 mg cloxacillin and 500 mg cephalexin.2. High mixed saliva levels were ob...

journal_title：British journal of pharmacology

authors： Speirs CF,Stenhouse D,Stephen KW,Wallace ET

更新日期：1971-09-01 00:00:00

abstract：:1. Elevated plasminogen activator inhibitor 1 (PAI-1) is a risk factor for thrombosis, and inhibitors of the interaction between PAI-1 and tissue plasminogen activator (t-PA) have antithrombotic and prothrombolytic activity in animals. We describe the antithrombotic effects in the rat of a monoclonal antibody (MA33H1)...

journal_title：British journal of pharmacology

authors： Berry CN,Lunven C,Lechaire I,Girardot C,O'Connor SE

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The effects of systemic treatment with indomethacin-loaded nanocapsules (IndOH-NC) were compared with those of free indomethacin (IndOH) in rat models of acute and chronic oedema. EXPERIMENTAL APPROACH:The following models of inflammation were employed: carrageenan-induced acute oedema (measured...

journal_title：British journal of pharmacology

authors： Bernardi A,Zilberstein AC,Jäger E,Campos MM,Morrone FB,Calixto JB,Pohlmann AR,Guterres SS,Battastini AM

更新日期：2009-10-01 00:00:00

abstract：:1. Strength-duration curves for threshold mechanical responses to single transmural stimuli were identical for rat and guinea-pig detrusor. In both species atropine had no effect on the curves, but the curves were shifted to the right by nerve blockade with tetrodotoxin (TTX), and by blockade of P2-purinoceptors with ...

journal_title：British journal of pharmacology

authors： Brading AF,Williams JH

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is increasing evidence that potassium channels are involved in the cardiovascular dysfunction of sepsis. This evidence was obtained after the systemic inflammation, cardiovascular dysfunction and organ damage had developed. Here we have studied the consequences of early interference with po...

journal_title：British journal of pharmacology

authors： Sordi R,Fernandes D,Heckert BT,Assreuy J

更新日期：2011-07-01 00:00:00

abstract：:Monoamine oxidase and aldehyde dehydrogenase activity were significantly reduced in the striatum of rats 8 days after lesion of the nigrostriatal nerve pathway caused by 6-hydroxydopamine. Evidence is presented for the existence of an intraneuronal 'dopamine monoamine oxidase' and intraneuronal aldehyde dehydrogenase....

journal_title：British journal of pharmacology

authors： Agid Y,Javoy F,Youdim MB

更新日期：1973-05-01 00:00:00

abstract：:The aims of this study were to develop a technique to measure blood flow in the mouse ear and to investigate the nature of the vasodilator mediator(s) involved in the response to capsaicin. The response to capsaicin, applied topically, was investigated in anaesthetized CD1 or Sv129+C57BL/6 wild-type (+/+) or NK(1) rec...

journal_title：British journal of pharmacology

authors： Grant AD,Gerard NP,Brain SD

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive sensory nerves induce local neurogenic inflammation; somatostatin exerts systemic anti-inflammatory actions presumably via sst4/sst1 receptors. This study investigates the effects of a high affinity, sst...

journal_title：British journal of pharmacology

authors： Helyes Z,Pintér E,Németh J,Sándor K,Elekes K,Szabó A,Pozsgai G,Keszthelyi D,Kereskai L,Engström M,Wurster S,Szolcsányi J

更新日期：2006-10-01 00:00:00

abstract：:1. The effects of various metabotropic glutamate receptor agonists on [3H]-cyclic AMP accumulation and phosphoinositide hydrolysis were investigated in guinea-pig cerebral cortical slices prelabelled with [3H]-adenine or [3H]-inositol. 2. 1-Aminocyclopentane-1S,3R-dicarboxylate (1S,3R-ACPD), L-2-amino-4-phosphonobutan...

journal_title：British journal of pharmacology

authors： Cartmell J,Kemp JA,Alexander SP,Shinozaki H,Kendall DA

更新日期：1994-01-01 00:00:00

abstract：:1. The effect of the myorelaxant drugs baclofen, diazepam and tizanidine have been compared on in vitro preparations of baby rat spinal cord and adult rat superior cervical ganglion. 2. Dorsal root-elicited long duration (time to half decay 9.71 +/- 0.29 s.e. mean, n = 31) ipsilateral ventral root reflexes (DR-VRP), m...

journal_title：British journal of pharmacology

authors： Siarey RJ,Long SK,Evans RH

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:While remifentanil can be used either during labour or fetal surgery, more should be known about the transplacental transfer of this opioid. The aim of this study was to investigate the placental transfer and haemodynamic effects of remifentanil after i.v. administration to pregnant ewes. EXPERI...

journal_title：British journal of pharmacology

authors： Coonen JB,Marcus MA,Joosten EA,van Kleef M,Neef C,van Aken H,Gogarten W

更新日期：2010-12-01 00:00:00

abstract：:We synthesized a small-molecule opioid receptor-like 1 (ORL1) receptor agonist, 2-{3-[1-((1R)-acenaphthen-1-yl)piperidin-4-yl]-2,3-dihydro-2-oxo-benzimidazol-1-yl}-N-methylacetamide (W-212393), and investigated its effect on the circadian body temperature rhythm of rats. W-212393 has high affinity for ORL1 receptors i...

journal_title：British journal of pharmacology

authors： Teshima K,Minoguchi M,Tounai S,Ashimori A,Eguchi J,Allen CN,Shibata S

更新日期：2005-09-01 00:00:00

abstract：:1. We have compared the effects of ouabain on the maintenance of gap junctional communication in rat aortic A7r5 smooth muscle cells, monkey COS-1 fibroblasts and human HeLa epithelial cells. 2. Ouabain (1 mM) interrupted dye coupling between confluent A7r5 cells within approximately 1 h, and high concentrations of ou...

journal_title：British journal of pharmacology

authors： Martin PE,Hill NS,Kristensen B,Errington RJ,Griffith TM

更新日期：2003-12-01 00:00:00

abstract：:The molecular mechanisms involved in veratridine-induced chromaffin cell death have been explored. We have found that exposure to veratridine (30 microM, 1 h) produces a delayed cellular death that reaches 55% of the cells 24 h after veratridine exposure. This death has the features of apoptosis as DNA fragmentation c...

journal_title：British journal of pharmacology

authors： Jordán J,Galindo MF,Calvo S,González-García C,Ceña V

更新日期：2000-08-01 00:00:00

abstract：:The phenanthrene-derivative 9-phenanthrol is a recently identified inhibitor of the transient receptor potential melastatin (TRPM) 4 channel, a Ca(2+) -activated non-selective cation channel whose mechanism of action remains to be determined. Subsequent studies performed on other ion channels confirm the specificity o...

journal_title：British journal of pharmacology

authors： Guinamard R,Hof T,Del Negro CA

更新日期：2014-04-01 00:00:00

abstract：:1. The fall in arterial blood pressure with bradycardia that occurs on injection of clonidine into the cerebral ventricles and into the cisterna magna is attributed to an action on ;chemosensitive zones' situated at the ventral surface of the brain stem. This conclusion is based on the following results obtained in ca...

journal_title：British journal of pharmacology

authors： Bousquet P,Guertzenstein PG

更新日期：1973-12-01 00:00:00

abstract：:The effects of the opioid receptor agonist RX783006 and of the opioid receptor partial agonist (+)-meptazinol have been examined on electrically induced twitch responses of the guinea-pig isolated ileum and of the mouse isolated vas deferens. Log10 concentration-tissue state curves were determined for (+)-meptazinol a...

journal_title：British journal of pharmacology

authors： Goodall J,Hughes IE,Mackay D

更新日期：1986-07-01 00:00:00

abstract：:1. The present study characterized highly effective agonists from different classes of compounds for the neuronal octopamine receptor (OAR3) of the migratory locust (Locusta migratoria L.). Biogenic amines and phenyliminoimidazolidines (PIIs) were employed for the study of structure-activity relationships. 2. The high...

journal_title：British journal of pharmacology

authors： Roeder T

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inhibition of PDE5 improves synaptic plasticity and memory via enhancing cGMP expression, thus activating the cGMP/cAMP response element binding protein (CREB) signalling pathway. This study investigated the effects of a PDE5 inhibitor on scopolamine-induced cognitive dysfunction, using memory-re...

journal_title：British journal of pharmacology

authors： Zhang L,Seo JH,Li H,Nam G,Yang HO

更新日期：2018-08-01 00:00:00

abstract：:1. It has previously been shown that the antimigraine drug, sumatriptan, a putative 5-HT1D receptor agonist, decreases porcine common carotid and arteriovenous anastomotic blood flows, but slightly increases the arteriolar (capillary) blood flow to the skin and ears. Interestingly, such responses, being mediated by 5-...

journal_title：British journal of pharmacology

authors： De Vries P,Heiligers JP,Villalón CM,Saxena PR

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Acute activation of κ opioid (KOP) receptors results in anticocaine-like effects, but adverse effects, such as dysphoria, aversion, sedation and depression, limit their clinical development. Salvinorin A, isolated from the plant Salvia divinorum, and its semi-synthetic analogues have been shown t...

journal_title：British journal of pharmacology

authors： Simonson B,Morani AS,Ewald AW,Walker L,Kumar N,Simpson D,Miller JH,Prisinzano TE,Kivell BM

更新日期：2015-01-01 00:00:00

abstract：:1. Arachidonic acid caused larger contractions to indomethacin-tested guinea-pig trachea than in control tracheae. 2. No change in contractions was obtained in tracheae treated with 5,8, 11, 14, eicosatetraynoic acid (ETYA 10 micro M). 3. ETYA (100 micro M) blocked the effect of indomethacin on arachidonic acid-induce...

journal_title：British journal of pharmacology

authors： Mitchell HW

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The locus coeruleus (LC) is a major source of noradrenergic projections to the dorsal spinal cord, and thereby plays an important role in the modulation of nociceptive information. The LC receives inputs from substance P (SP)-containing fibres from other regions, and expresses the NK(1) tachykin...

journal_title：British journal of pharmacology

authors： Muto Y,Sakai A,Sakamoto A,Suzuki H

更新日期：2012-06-01 00:00:00

abstract：:We investigated the ability of N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamide (AC-5216), a novel mitochondrial benzodiazepine receptor (MBR) ligand, to produce anti-anxiety and antidepressant-like effects in various animal models. AC-5216 showed high affinity for MBRs prepared from rat...

journal_title：British journal of pharmacology

authors： Kita A,Kohayakawa H,Kinoshita T,Ochi Y,Nakamichi K,Kurumiya S,Furukawa K,Oka M

更新日期：2004-08-01 00:00:00

abstract：:1. The aim of the present study was to explore the contribution of adrenergic, sensory and nitrergic innervations to the inhibitory effects of the beta2-adrenoceptor agonist clenbuterol on responses to electrical field stimulation (EFS, 200 mA, 0.3 ms, 1-16 Hz, for 30 s, at 1 min interval) in rat mesenteric artery seg...

journal_title：British journal of pharmacology

authors： Marín J,Balfagón G

更新日期：1998-06-01 00:00:00

abstract：:1. The cyclic analogue of dopamine, 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN) was injected into the lateral ventricle or bilaterally into the nucleus accumbens or caudate nucleus of conscious rats and its effect on locomotor activity was investigated. 2. When given intraventricularly, ADTN produced so...

journal_title：British journal of pharmacology

authors： Elkhawad AO,Woodruff GN

更新日期：1975-05-01 00:00:00

abstract：:The mechanism of action of prostacyclin (PGI2) on isolated segments of guinea-pig terminal ileum was studied by recording the changes in isometric tension. In these preparations PGI2 (1 nM-1 microM) caused a concentration-dependent increase in muscle tension. This effect was rapid and short-lasting. PGI2-induced contr...

journal_title：British journal of pharmacology

authors： Gaion RM,Trento M

更新日期：1983-10-01 00:00:00

abstract：:The endogenous concentrations of p- and m-hydroxyphenylacetic acid in the mouse caudate nucleus were determined by a gas chromatographic or a gas chromatographic-mass spectrometric technique and the concentrations were about 30 and 11 ng g-1 respectively. The subcutaneous administration of (+)-butaclamol (1 mg kg-1), ...

journal_title：British journal of pharmacology

authors： Juorio AV,McQuade PS

更新日期：1983-11-01 00:00:00

abstract：:1 We have investigated the effects of platelet-activating factor (PAF), an endogenous mediator of inflammation, on ion transport and prostaglandin synthesis in the human isolated colon. 2 Application of PAF to the serosal surface of human colonic mucosa induced a marked, concentration-dependent increase in ion transpo...

journal_title：British journal of pharmacology

authors： Borman RA,Jewell R,Hillier K

更新日期：1998-01-01 00:00:00

abstract：:The cardiotoxic effects of fenfluramine hydrochloride on mechanical and electrical activity were studied in papillary muscles, Purkinje fibres, left atria and ventricular myocytes of guinea-pigs. Force of contraction (f(c)) was measured isometrically, action potentials and maximum rate of rise of the action potential ...

journal_title：British journal of pharmacology

authors： Rajamani S,Studenik C,Lemmens-Gruber R,Heistracher P

更新日期：2000-03-01 00:00:00