The role of prostacyclin in modulating cholinergic neurotransmission in guinea-pig ileum.

abstract：BACKGROUND AND PURPOSE:Voltage-gated sodium channels (VGSCs) are assembled from two classes of subunits, a pore-bearing α-subunit (NaV 1) and one or two accessory β-subunits (NaV βs). Neurons in mammals can express one or more of seven isoforms of NaV 1 and one or more of four isoforms of NaV β. The peptide μ-conotoxin...

journal_title：British journal of pharmacology

authors： Zhang MM,Wilson MJ,Azam L,Gajewiak J,Rivier JE,Bulaj G,Olivera BM,Yoshikami D

更新日期：2013-04-01 00:00:00

abstract：:Adrenergic transmission was investigated in the dog mesenteric vein by recording electrical responses of single smooth muscle cells to perivascular nerve stimulation. Perivascular nerve stimulation generated an excitatory junction potential (e.j.p.) and a slow depolarization of the membrane. The amplitude of the e.j.p...

journal_title：British journal of pharmacology

authors： Suzuki H

更新日期：1984-03-01 00:00:00

abstract：:The study was undertaken to investigate the 5-HT receptor mediating the inhibitory effect of 5-HT on peristalsis in the guinea-pig isolated ileum. The facilitatory and inhibitory effects were measured as the decrease and increase, respectively, in the intraluminal pressure required to trigger peristalsis. In the prese...

journal_title：British journal of pharmacology

authors： Tuladhar BR,Ge L,Naylor RJ

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This study investigated the role of central sympathetic activity and related mitogen-activated protein kinase (MAPK) signalling in the cardiovascular effects of ethanol in a model of acute renal failure (ARF). EXPERIMENTAL APPROACH:The effects of pharmacological interventions that inhibit periph...

journal_title：British journal of pharmacology

authors： El-Mas MM,El-Gowelli HM,Ghazal AR,Harraz OF,Mohy El-Din MM

更新日期：2009-11-01 00:00:00

abstract：:ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, were evaluated with a fibroblastic cell line from bovine embryonic trachea (EBTr) which specifically responds to prostaglandin D2 (PGD2). ZK110841, equipotent to PGD2, elevated the adenosine 3':5'-cyclic monophosphate (...

journal_title：British journal of pharmacology

authors： Ito S,Okuda E,Sugama K,Negishi M,Hayaishi O

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Melanin-concentrating hormone receptor 1 (MCH1 receptor) antagonists are being considered as anti-obesity agents. The present study reports a new class of MCH1 receptor antagonists with an 8-methylquinoline scaffold. The molecular mechanism of MCH1 receptor blockade by these antagonists was exami...

journal_title：British journal of pharmacology

authors： Sakurai T,Ogawa K,Ishihara Y,Kasai S,Nakayama M

更新日期：2014-03-01 00:00:00

abstract：:1 This study investigated the effects of soluble complement receptor type 1 (sCR1) or sCR1sLex, agents which function as a complement inhibitor or as a combined complement inhibitor and selectin adhesion molecule antagonist, respectively, on the infarct size and cardiac troponin T (cTnT) release caused by regional myo...

journal_title：British journal of pharmacology

authors： Zacharowski K,Otto M,Hafner G,Marsh HC Jr,Thiemermann C

更新日期：1999-11-01 00:00:00

abstract：:Along with many other mammalian ATP-binding cassette (ABC) transporters, members of the ABCG group are involved in the regulated transport of hydrophobic compounds across cellular membranes. In humans, five ABCG family members have been identified, encoding proteins ranging from 638 to 678 amino acids in length. All f...

journal_title：British journal of pharmacology

authors： Kerr ID,Haider AJ,Gelissen IC

更新日期：2011-12-01 00:00:00

abstract：:The effects of caffeine and procaine on noradrenergic transmission in the guinea-pig mesenteric artery were investigated by recording electrical responses of smooth muscle cells and by measuring the outflow of noradrenaline (NA) and 3,4-dihydroxyphenylglycol (DOPEG) induced by perivascular nerve stimulation. Caffeine ...

journal_title：British journal of pharmacology

authors： Fujii K,Miyahara H,Suzuki H

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Metformin, a small molecule, antihyperglycaemic agent, is a well-known activator of AMP-activated protein kinase (AMPK) and protects against cardiac fibrosis. However, the underlying mechanisms remain elusive. TGFβ1 is a key cytokine mediating cardiac fibrosis. Here, we investigated the effects o...

journal_title：British journal of pharmacology

authors： Chen R,Feng Y,Wu J,Song Y,Li H,Shen Q,Li D,Zhang J,Lu Z,Xiao H,Zhang Y

更新日期：2018-04-01 00:00:00

abstract：:Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are canonically activated by oxidized derivatives of cholesterol. Since the mid-90s, numerous groups have identified LXRs as endocrine receptors that are involved in the regulation of various physiological functions. As a result, when their ...

journal_title：British journal of pharmacology

authors： Buñay J,Fouache A,Trousson A,de Joussineau C,Bouchareb E,Zhu Z,Kocer A,Morel L,Baron S,Lobaccaro JA

更新日期：2020-10-20 00:00:00

abstract：:1. Idioventricular rate responses and adrenoceptor number have been examined in normal Langendorff hearts perfused at 70 cmH2O and in 'ischaemic' hearts perfused at 10 cmH2O. 2. In hearts perfused at normal pressure, ventricular rate responses to phenylephrine in the presence of propranolol were biphasic with low conc...

journal_title：British journal of pharmacology

authors： Butterfield MC,Chess-Williams R

更新日期：1990-07-01 00:00:00

abstract：:1. 5-Hydroxytryptamine (5-HT) stimulates active sodium transport and decreases the passive mucosal to serosal chloride permeability across frog skin. The relative importance of the different regions of the 5-HT molecule in the mediation of these responses has been studied using a range of structurally related compound...

journal_title：British journal of pharmacology

authors： Dalton T

更新日期：1979-04-01 00:00:00

abstract：:The selective monoamine oxidase (MAO) inhibitors clorgyline, selegiline and AGN 1135 did not cause a change in responses of the cat nictitating membrane to preganglionic sympathetic nerve stimulation at 5 Hz. Both selective MAO-A and MAO-B inhibitors markedly potentiated nictitating membrane contractions in response t...

journal_title：British journal of pharmacology

authors： Finberg JP,Youdim MB

更新日期：1985-06-01 00:00:00

abstract：:1 Hypolipidaemic agents may increase biliary cholesterol in man, inducing a supersaturated bile. 2 To evaluate this possible side-effect, we have studied bile lipid secretion over a period of 8 h with intact enterohepatic circulation and 4 h with complete interruption in rats treated for two months with a salt of chol...

journal_title：British journal of pharmacology

authors： Aldini R,Barbara L,Benelli A,Borzatta V,Geminiani S,Mascellani G,Morselli A,Roda A,Roda E

更新日期：1981-11-01 00:00:00

abstract：:1. Perivascular nerves of the sheep middle cerebral artery show immunoreactivity for both vasoactive intestinal polypeptide (VIP) and calcitonin gene-related peptide (CGRP). 2. Rings of endothelium-denuded sheep middle cerebral artery precontracted with 5-hydroxytryptamine were relaxed by CGRP (maximum relaxation = 87...

journal_title：British journal of pharmacology

authors： Gaw AJ,Aberdeen J,Humphrey PP,Wadsworth RM,Burnstock G

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The human, rat, and mouse P2X(7) receptors have been previously characterized, and in this study we report the cloning and pharmacological properties of the guinea pig orthologue. EXPERIMENTAL APPROACH:A cDNA encoding for the guinea pig P2X(7) receptor was isolated from a guinea pig brain librar...

journal_title：British journal of pharmacology

authors： Fonfria E,Clay WC,Levy DS,Goodwin JA,Roman S,Smith GD,Condreay JP,Michel AD

更新日期：2008-02-01 00:00:00

abstract：:The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more deta...

journal_title：British journal of pharmacology

authors： Alexander SP,Christopoulos A,Davenport AP,Kelly E,Marrion NV,Peters JA,Faccenda E,Harding SD,Pawson AJ,Sharman JL,Southan C,Davies JA,CGTP Collaborators.

更新日期：2017-12-01 00:00:00

abstract：:1. Chronic benzodiazepine administration has been associated with tolerance and with downregulation of gamma-aminobutyric acidA (GABAA)-receptor binding and function. However, effects of individual benzodiazepines on brain regions have varied. 2. To compare the effects of chronic lorazepam and alprazolam, we have admi...

journal_title：British journal of pharmacology

authors： Galpern WR,Miller LG,Greenblatt DJ,Shader RI

更新日期：1990-12-01 00:00:00

abstract：:1 Very highly purified (greater than 100,000 u/mg) slow reacting substance of anaphylaxis (SRS-A) has been prepared by reversed phase high pressure liquid chromatographic (HPLC) techniques. 2 High resolution liquid chromatography suggests that SRS-A may exist in at least three distinct forms which are possible tautome...

journal_title：British journal of pharmacology

authors： Blackwell GJ,Burka JF,Flower RJ,Torkington P

更新日期：1980-01-01 00:00:00

abstract：:1. This study examined beta-adrenoceptor signalling in cardiac tissues following infusion of isoprenaline (400 microg kg(-1) h(-1)) or vehicle to rats for 14 days. 2. Isoprenaline infusion caused marked hypertrophy of atria and ventricles and reduced the resting rate of spontaneously beating right atria and the basal ...

journal_title：British journal of pharmacology

authors： McMartin L,Summers RJ

更新日期：1999-06-01 00:00:00

abstract：:1. The binding of 1,3-[3H]-dipropyl-8-cyclopentylxanthine ([3H]-DPCPX), an antagonist radioligand selective for adenosine A1 receptors, was studied in rat duodenum, colon muscularis mucosae and longitudinal muscle, urinary bladder and vasa deferentia. 2. [3H]-DPCPX bound with high affinity to a single site in all memb...

journal_title：British journal of pharmacology

authors： Peachey JA,Hourani SM,Kitchen I

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:3,4-Methylenedioxymethamphetamine (MDMA or 'Ecstasy') is a worldwide major drug of abuse known to elicit neurotoxic effects. The mechanisms underlying the neurotoxic effects of MDMA are not clear at present, but the metabolism of dopamine and 5-HT by monoamine oxidase (MAO), as well as the hepati...

journal_title：British journal of pharmacology

authors： Barbosa DJ,Capela JP,Oliveira JM,Silva R,Ferreira LM,Siopa F,Branco PS,Fernandes E,Duarte JA,de Lourdes Bastos M,Carvalho F

更新日期：2012-02-01 00:00:00

abstract：:1. The effects of several drugs, including antagonists of vasoactive intestinal peptide (VIP), and antisera to VIP or peptide histidine isoleucine (PHI), on relaxation responses of guinea-pig isolated trachea to electrical field stimulation (EFS) have been examined. 2. beta-Adrenoceptor blockade with propranolol only ...

journal_title：British journal of pharmacology

authors： Ellis JL,Farmer SG

更新日期：1989-03-01 00:00:00

abstract：:1. The effects of intrathecally (i.t.) injected substance P (SP), neurokinin A (NKA), [beta-Ala8]NKA (4-10) and [MePhe7]neurokinin B (NKB) at T13 thoracic spinal cord level were investigated on renal excretion of water, sodium and potassium in the conscious saline-loaded rat. Antagonists selective for NK1 (RP 67580), ...

journal_title：British journal of pharmacology

authors： Yuan YD,Couture R

更新日期：1997-07-01 00:00:00

abstract：:1 The effects of a subconstrictor dose of histamine (9 x 10(-7) mol/l) on the responses of the isolated perfused ear artery of the rabbit to electrical stimulation (E.S.) and to exogenous noradrenaline (NA) were investigated.2 Both intraluminal (I/L) and extraluminal (E/L) histamine potentiated responses to E.S. and t...

journal_title：British journal of pharmacology

authors： Foldes A,Hall RC

更新日期：1979-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common age related neurodegenerative disease. Currently, there are no disease modifying drugs, existing therapies only offer short-term symptomatic relief. Two of the pathognomonic indicators of AD are the presence of extracellular protein aggregates consisting primarily of the Aβ ...

journal_title：British journal of pharmacology

authors： Kenche VB,Barnham KJ

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sulphatides are sulphated glycosphingolipids expressed on the surface of many cell types, particularly neurones. Changes in sulphatide species or content have been associated with epilepsy and Alzheimer's disease. As the large conductance, calcium sensitive K(+) channel (BK(Ca)) are modulated by ...

journal_title：British journal of pharmacology

authors： Chi S,Qi Z

更新日期：2006-12-01 00:00:00

abstract：:1. An antisense approach to block nitric oxide (NO) synthesis was developed, complementing the widely used chemical inhibitors and overcoming problems associated with their use in studying the roles of NO. 2. Murine macrophage cell lines (J774.2) were generated expressing a 500 bp sequence from inducible NO synthase (...

journal_title：British journal of pharmacology

authors： Cartwright JE,Johnstone AP,Whitley GS

更新日期：1997-01-01 00:00:00

abstract：:1. Reserpine given to rats before the enhanced synthesis of DNA begins 14h after partial hepatectomy markedly depresses thymidine uptake into DNA at 24 hours.2. At this time decreased activity of liver thymidine kinase but unchanged thymidine 5'-nucleotidase were observed.3. Reserpine has no effect on DNA synthesis wh...

journal_title：British journal of pharmacology

authors： Cihák A,Vaptzarova K

更新日期：1973-10-01 00:00:00