Abstract：
:The effects of the opioid receptor agonist RX783006 and of the opioid receptor partial agonist (+)-meptazinol have been examined on electrically induced twitch responses of the guinea-pig isolated ileum and of the mouse isolated vas deferens. Log10 concentration-tissue state curves were determined for (+)-meptazinol and RX783006, alone, in combination and in the presence of naloxone (30 nM). Analysis of these log10 concentration-tissue state curves using the null equations derived and tested in the preceding paper indicates that the opioid agonist action of (+)-meptazinol on mouse vas deferens is quantitatively similar to that on guinea-pig ileum. The results also suggest that (+)-meptazinol acts as a functional antagonist on the guinea-pig ileum as well as on the mouse vas deferens. The potency of (+)-meptazinol relative to RX783006 has been measured by an indirect method which should eliminate any functional antagonistic action of (+)-meptazinol. This method gives a relative potency of (+)-meptazinol in both tissues which is three to six times greater than that measured directly on guinea-pig ileum. This discrepancy may be due to experimental error but it may also indicate that direct measurements on guinea-pig ileum underestimate the agonist potency of this compound on opioid receptors.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Goodall J,Hughes IE,Mackay Ddoi
10.1111/j.1476-5381.1986.tb10246.xsubject
Has Abstractpub_date
1986-07-01 00:00:00pages
645-51issue
3eissn
0007-1188issn
1476-5381journal_volume
88pub_type
杂志文章abstract：:1. Experiments were designed to investigate the effects of the inducible nitric oxide synthase (iNOS) stimulator, lipopolysaccharide (LPS), on noradrenaline (NA) responses and on NOS activity and its expression in intact mesenteric resistance arteries (MRAs) from Wistar Kyoto (WKY) and spontaneously hypertensive (SHR)...
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journal_title：British journal of pharmacology
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journal_title：British journal of pharmacology
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journal_title：British journal of pharmacology
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pub_type： 杂志文章
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journal_title：British journal of pharmacology
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更新日期：1982-11-01 00:00:00
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journal_title：British journal of pharmacology
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doi：10.1111/j.1476-5381.1988.tb10316.x
更新日期：1988-03-01 00:00:00
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更新日期：2004-06-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章
doi：10.1111/j.1476-5381.1986.tb10176.x
更新日期：1986-01-01 00:00:00
abstract：:1. The aim of this study was to investigate whether the hypotensive effect of rat alpha-calcitonin gene-related peptide (alpha CGRP) in conscious rats is mediated by endothelium-derived nitric oxide (NO) or the opening of adenosine 5'-triphosphate (ATP)-sensitive potassium (KATP) channels. 2. Dose-mean arterial pressu...
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更新日期：2002-01-01 00:00:00
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journal_title：British journal of pharmacology
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journal_title：British journal of pharmacology
pub_type： 杂志文章
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