Role of putative neurotransmitters in the central gastric antisecretory effect of prostaglandin E2 in rats.

abstract：:1. Ca2+ buffering function of sarcoplasmic reticulum (SR) in the resting state of arteries from spontaneously hypertensive rats (SHR) was examined. Differences in the effects of cyclopiazonic acid (CPA) and thapsigargin, agents which inhibit the Ca(2+)-ATPase of SR, on tension and cellular Ca2+ level were assessed in ...

journal_title：British journal of pharmacology

authors： Nomura Y,Asano M,Ito K,Uyama Y,Imaizumi Y,Watanabe M

更新日期：1997-01-01 00:00:00

abstract：:1. To determine the possible role of Ca(2+)-activated K+ (KCa) channels in the regulation of resting tone of arteries from spontaneously hypertensive rats (SHR), the effects of agents which interact with these channels on tension and 86Rb efflux were compared in endothelium-denuded strips of carotid, femoral and mesen...

journal_title：British journal of pharmacology

authors： Asano M,Masuzawa-Ito K,Matsuda T

更新日期：1993-01-01 00:00:00

abstract：:1. Vasospasm of arterial conduits used for coronary artery surgery is an important cause of graft failure and is likely to result partly from raised levels of vasoconstrictor substances such as thromboxane A(2) and endothelin-1. Our aim was to find pharmacological agents that could prevent agonist-induced vasospasm. 2...

journal_title：British journal of pharmacology

authors： Batchelor TJ,Sadaba JR,Ishola A,Pacaud P,Munsch CM,Beech DJ

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Oxaliplatin is a platinum-based chemotherapeutic drug used as a first-line therapy for colorectal cancer. However, its use is associated with severe gastrointestinal side-effects resulting in dose limitations and/or cessation of treatment. In this study, we tested whether oxidative stress, caused...

journal_title：British journal of pharmacology

authors： McQuade RM,Carbone SE,Stojanovska V,Rahman A,Gwynne RM,Robinson AM,Goodman CA,Bornstein JC,Nurgali K

更新日期：2016-12-01 00:00:00

abstract：:1. Adenosine 5'-triphosphate (ATP) is known to augment cardiac contractile activity and cause an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in isolated cardiomyocytes. However, no information regarding the ATP-mediated signal transduction in the myocardium in congestive heart failure (CHF) is availab...

journal_title：British journal of pharmacology

authors： Saini HK,Shao Q,Musat S,Takeda N,Tappia PS,Dhalla NS

更新日期：2005-01-01 00:00:00

abstract：:1 Non-adrenergic non-cholinergic (NANC) vasodilator nerves regulate tone in certain vascular beds. We have investigated the mechanisms of the NANC dilator response in the isolated small mesenteric artery of the rabbit by use of the tension myograph. 2 Small second or third order (150-300 microm in diameter) arteries o...

journal_title：British journal of pharmacology

authors： Kakuyama M,Vallance P,Ahluwalia A

更新日期：1998-01-01 00:00:00

abstract：:1. The effects of pregnancy on mesenteric arterial function were examined in constantly perfused (5 ml min-1) mesenteric arterial beds isolated from 21-day pregnant rats. The function of sympathetic and sensory-motor perivascular nerves, endothelium and smooth muscle was examined. The role of nitric oxide and prostagl...

journal_title：British journal of pharmacology

authors： Ralevic V,Burnstock G

更新日期：1996-04-01 00:00:00

abstract：:1. Riluzole has been shown to have beneficial effects in motoneurone disease, yet its effect on motoneurones is not known. To address this question, we investigated synaptic modulation by riluzole in hypoglossal motoneurones by recording glycinergic inhibitory postsynaptic currents evoked by stimulation of nearby sing...

journal_title：British journal of pharmacology

authors： Umemiya M,Berger AJ

更新日期：1995-12-01 00:00:00

abstract：:1. The effect of purified crotapotin, a non-toxic non-enzymatic chaperon protein normally complexed to a phospholipase A2 (PLA2) in South America rattlesnake venom, was studied in the acute inflammatory response induced by carrageenin (1 mg/paw), compound 48/80 (3 micrograms/paw) and 5-hydroxytryptamine (5-HT) (3 micr...

journal_title：British journal of pharmacology

authors： Landucci EC,Antunes E,Donato JL,Faro R,Hyslop S,Marangoni S,Oliveira B,Cirino G,de Nucci G

更新日期：1995-02-01 00:00:00

abstract：:1. The mechanism of toxicity of sulphur mustard was investigated by examining the biochemical effects of the analog 2-chloroethylethyl sulphide (CEES) in both human Jurkat cells as well as normal human lymphocytes. 2. Exposure of both types of cells to CEES resulted in a marked decrease in the intracellular concentrat...

journal_title：British journal of pharmacology

authors： Han S,Espinoza LA,Liao H,Boulares AH,Smulson ME

更新日期：2004-03-01 00:00:00

abstract：:1. The effects of the selective alpha 2-adrenoceptor agonist, medetomidine, were assessed on plasma levels of immunoreactive atrial natriuretic peptide (IR-ANP), haemodynamics and on urine water and solute excretion in conscious, chronically cannulated, 7 month-old spontaneously hypertensive (SHR) and age-matched Wist...

journal_title：British journal of pharmacology

authors： Ruskoaho H,Leppäluoto J

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dilatation of cerebral and dural arteries causes a throbbing, migraine-like pain, indicating that these structures are involved in migraine. Clinical trials suggest that adenosine 5'-triphosphate-sensitive K(+) (K(ATP)) channel opening may cause migraine by dilatating intracranial arteries, inclu...

journal_title：British journal of pharmacology

authors： Ploug KB,Boni LJ,Baun M,Hay-Schmidt A,Olesen J,Jansen-Olesen I

更新日期：2008-05-01 00:00:00

abstract：:1. The effects of the beta 1- and beta 2-adrenoceptor selective antagonists, CGP 20712A and ICI 118551 respectively, on responses to isoprenaline-induced relaxation of rat distal colon were investigated in order to determine the contributions of these subtypes to relaxation. In addition, the properties of ICI D7114, a...

journal_title：British journal of pharmacology

authors： MacDonald A,Lamont M

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:3,4-Methylenedioxymethamphetamine (MDMA or 'Ecstasy') is a worldwide major drug of abuse known to elicit neurotoxic effects. The mechanisms underlying the neurotoxic effects of MDMA are not clear at present, but the metabolism of dopamine and 5-HT by monoamine oxidase (MAO), as well as the hepati...

journal_title：British journal of pharmacology

authors： Barbosa DJ,Capela JP,Oliveira JM,Silva R,Ferreira LM,Siopa F,Branco PS,Fernandes E,Duarte JA,de Lourdes Bastos M,Carvalho F

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pancreatic islet transplantation is a promising therapeutic approach for Type 1 diabetes. A major prerequisite for the survival of grafted islets is a rapid revascularization after transplantation. Erythropoietin (EPO), the primary regulator of erythropoiesis, has been shown to promote angiogenes...

journal_title：British journal of pharmacology

authors： Menger MM,Nalbach L,Roma LP,Körbel C,Wrublewsky S,Glanemann M,Laschke MW,Menger MD,Ampofo E

更新日期：2020-04-01 00:00:00

abstract：:1. In mouse pancreatic beta-cells the regulation of the diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel (K-ATP-channel) was examined by use of the patch-clamp technique. 2. In intact beta-cells incubated at 37 degrees C in the presence of 3 mM D-glucose, diazoxide did not affect the single ...

journal_title：British journal of pharmacology

authors： Schwanstecher C,Dickel C,Ebers I,Lins S,Zünkler BJ,Panten U

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pharmacokinetic/pharmacodynamic (PK/PD) models are necessary to relate the degree of drug exposure in vivo to target blockade and pharmacological efficacy. This manuscript describes a murine agonist-induced CXCR3 receptor internalization assay and demonstrates its utility for PK/PD analyses. EXP...

journal_title：British journal of pharmacology

authors： Jopling LA,Watt GF,Fisher S,Birch H,Coggon S,Christie MI

更新日期：2007-12-01 00:00:00

abstract：:We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by alpha-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages. DFMO potentiated LPS-stimulated nitrite production in both a concentration- and t...

journal_title：British journal of pharmacology

authors： Baydoun AR,Morgan DM

更新日期：1998-12-01 00:00:00

abstract：:Relaxin is a small heterodimeric peptide hormone of the insulin/relaxin superfamily produced mainly in female and male reproductive organs. It has potent antifibrotic, vasodilatory and angiogenic effects and regulates the normal function of various physiological systems. Preclinical studies and recent clinical trials ...

journal_title：British journal of pharmacology

authors： Agoulnik AI,Agoulnik IU,Hu X,Marugan J

更新日期：2017-05-01 00:00:00

abstract：:1. The sulphonylureas, tolbutamide (0.1-10 mM) and glibenclamide (0.1-100 microM) shown not to inhibit ATP-K+ channel currents when applied to inside-out membrane patches excised from rat cultured cerebral cortex or freshly-dispersed ventromedial hypothalamic nucleus (VMHN) neurones. 2. Saturable binding sites for [3H...

journal_title：British journal of pharmacology

authors： Ashford ML,Boden PR,Treherne JM

更新日期：1990-11-01 00:00:00

abstract：:Excessive death of cardiac myocytes leads to many cardiac diseases, including myocardial infarction, arrhythmia, heart failure and sudden cardiac death. For the last several decades, most work on cell death has focused on apoptosis, which is generally considered as the only form of regulated cell death, whereas necros...

journal_title：British journal of pharmacology

authors： Zhang J,Liu D,Zhang M,Zhang Y

更新日期：2019-11-01 00:00:00

abstract：:1. The present study was designed to evaluate the nature of intervening agents in L-DOPA- and dopamine-induced neurotoxicity in Neuro-2A cells. 2. In the absence of cells and in conditions of light protection, at 37 degrees C, L-DOPA or dopamine (1 mM) in culture medium degraded spontaneously in a time-dependent manne...

journal_title：British journal of pharmacology

authors： Pedrosa R,Soares-da-Silva P

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sublesional osteoporosis predisposes individuals with spinal cord injury (SCI) to an increased risk of low-trauma fracture. The aim of the present work was to investigate the effect of treatment with resveratrol (RES) on sublesional bone loss in spinal cord-injured rats. EXPERIMENTAL APPROACH:Co...

journal_title：British journal of pharmacology

authors： Wang HD,Shi YM,Li L,Guo JD,Zhang YP,Hou SX

更新日期：2013-10-01 00:00:00

abstract：:Obesity is a common metabolic disorder that has become a widespread epidemic in several countries. Sex and gender disparities in the prevalence of cardiovascular disease (CVD) have been well documented with premenopausal women having a lower incidence of CVD than age-matched men. However, women are more likely than me...

journal_title：British journal of pharmacology

authors： Taylor LE,Ramirez LA,Musall JB,Sullivan JC

更新日期：2019-11-01 00:00:00

abstract：:1. The rat spinal cord in vitro has been used to assess the effect of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on the dorsal root evoked extracellular ventral root reflex (DR-VRR) and the intracellular excitatory postsynaptic potential (e.p.s.p.) in ventral horn neurones and motoneurones. 2. CNQX (1-5 microM) produ...

journal_title：British journal of pharmacology

authors： King AE,Lopez-Garcia JA,Cumberbatch M

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tumour cell-induced platelet aggregation (TCIPA) facilitates cancer cell invasion, angiogenesis and the formation of metastatic foci. TCIPA can be modulated by pharmacological inhibitors of MMP-2 and ADP; however, the COX inhibitor aspirin did not prevent TCIPA. In this study, we have tested the ...

journal_title：British journal of pharmacology

authors： Medina C,Harmon S,Inkielewicz I,Santos-Martinez MJ,Jones M,Cantwell P,Bazou D,Ledwidge M,Radomski MW,Gilmer JF

更新日期：2012-06-01 00:00:00

abstract：:The pharmacological properties of endothelin receptors (ETR) were investigated in guinea-pig bronchus by comparing binding and functional results. In binding assays, both the ET(B) agonists, endothelin-3 (ET-3) and N-suc-[Glu9,Ala11,15]ET-1(8-21) (IRL 1620), and the antagonist, N-cis-2,6-dimethylpiperidinocarbonyl-L-g...

journal_title：British journal of pharmacology

authors： Mazzoni MR,Breschi MC,Ceccarelli F,Lazzeri N,Giusti L,Nieri P,Lucacchini A

更新日期：1999-07-01 00:00:00

abstract：:The binding of a series of amide derivatives of methotrexate to Lactobacillus casei dihydrofolate reductase has been studied by inhibition constant measurements and by 1H n.m.r. spectroscopy. Amide modification of the alpha-carboxylate of methotrexate was found to prevent interaction of the gamma-carboxylate with the ...

journal_title：British journal of pharmacology

authors： Antonjuk DJ,Birdsall B,Cheung HT,Clore GM,Feeney J,Gronenborn A,Roberts GC,Tran TQ

更新日期：1984-02-01 00:00:00

abstract：:1 The effects of electrical stimulation, changes in external ion concentrations and various drugs on acetylcholine release from the myenteric plexus were measured by bioassay in the presence of physostigmine and by recording the responses of the longitudinal muscle. In preparations from the guinea-pig, the acetylcholi...

journal_title：British journal of pharmacology

authors： Cowie AL,Kosterlitz HW,Waterfield AA

更新日期：1978-12-01 00:00:00

abstract：:The antioestrogen, tamoxifen, blocks volume-regulated chloride channels and reduces transparency in bovine lenses maintained in vitro. In contrast to tamoxifen, the steroidal antioestrogen, ICI 182780, did not block volume-regulated chloride currents in three cultured cell lines and required 10 fold higher concentrati...

journal_title：British journal of pharmacology

authors： Zhang JJ,Jacob TJ,Hardy SP,Higgins CF,Valverde MA

更新日期：1995-08-01 00:00:00