Abstract:
:Diltiazem (DTZ) is an optically active calcium channel blocker having a benzodiazepine structure. The drug used in therapy is (+)-cis-diltiazem with configuration (2S,3S). To describe the analytical profile of DTZ different stationary phases (RP-18, RP-8, monolithic support) were tested. The best separation of DTZ from A, B, E and F was obtained using as stationary phase a RP-8 or a monolithic RP-18. The characterization of impurities was carried out using two analytical systems, HPLC and HPLC/MS.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Quaglia MG,Donati E,Fanali S,Bossù E,Montinaro A,Buiarelli Fdoi
10.1016/j.jpba.2004.11.050subject
Has Abstractpub_date
2005-04-01 00:00:00pages
695-701issue
4eissn
0731-7085issn
1873-264Xpii
S0731-7085(04)00639-9journal_volume
37pub_type
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