Abstract:
:Herein we describe for the first time a practical analytical method for determining the enantio-purity of L-α-glycerophosphocholine (L-α-GPC) by chiral derivatization. The use of a suitable chiral boronic acid allowed the formation of a mixture of two diastereomeric boronate esters whose ratio, carefully analyzed by 1HNMR spectroscopy, reflects L-α-GPC enantiomeric excesses. The determination of the enantiopurity of L-α-GPC furnishes convincing correlations with its manufacturing process.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
de Ferra L,Massa A,Di Mola A,Diehl Bdoi
10.1016/j.jpba.2020.113152subject
Has Abstractpub_date
2020-05-10 00:00:00pages
113152eissn
0731-7085issn
1873-264Xpii
S0731-7085(19)33108-5journal_volume
183pub_type
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