Abstract:
:Statisticians have long argued that randomized controlled trials should be sufficiently large to achieve their purpose, and for common diseases with major public health implications this has brought many benefits. However, there are many instances where it is unrealistic to expect clinicians to provide the information on which sample sizes are calculated and undue emphasis on trial size can be counterproductive. Examples of such trials are given and some general issues discussed, including the unhelpful contribution of hypothesis testing, the need for replication and the role of the statistician.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Matthews JNdoi
10.1002/sim.4780140204subject
Has Abstractpub_date
1995-01-30 00:00:00pages
115-26issue
2eissn
0277-6715issn
1097-0258journal_volume
14pub_type
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journal_title:Statistics in medicine
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journal_title:Statistics in medicine
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780111105
更新日期:1992-08-01 00:00:00
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