Role of low-osmolality contrast media in thromboembolic complications: scanning electron microscopy study.

Abstract:

:Numerous in vitro studies have found that clot formation may occur when blood is mixed directly with nonionic low-osmolality contrast media during angiographic procedures because of activation of hemostasis in the catheter; ionic contrast media, on the other hand, inhibit clot formation. Thirty patients were injected with low-osmolality contrast media--15 with ioxaglate, an ionic dimer, and 15 with iopamidol, a nonionic monomer. The inner wall of the angiographic catheter was studied with electron microscopy after selective catheterization of supraaortic vessels. Clot formation of various extent was observed in nine (60%) of the patients administered iopamidol. No coagulation process was found in the catheters of the patients administered ioxaglate. Results indicate that nonionic, low-osmolality contrast media may play a role in the formation of thromboembolisms.

journal_name

Radiology

journal_title

Radiology

authors

Casalini E

doi

10.1148/radiology.183.3.1584930

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

741-4

issue

3

eissn

0033-8419

issn

1527-1315

journal_volume

183

pub_type

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