Adult respiratory distress syndrome from overdose of tricyclic antidepressants.

Abstract:

:Adult respiratory distress syndrome (ARDS) from overdose of tricyclic antidepressants (TCA) has been reported but is not well known. During a 1-year period, 81 patients with serious overdose from tranquilizers and other psychotropic drugs were examined. TCA alone induced overdose in 30 patients or were combined with other drugs in 26 patients. Twenty-five (31%) patients had overdose from drugs other than TCA. Chest radiography revealed that 30 (54%) patients with TCA overdose and six (24%) patients with non-TCA overdose had abnormalities. Clinical and radiographic findings consistent with ARDS were noted in five (9%) patients with TCA overdose and none of the patients with non-TCA overdose. Five patients with TCA overdose and one (4%) patient with non-TCA overdose had interstitial edema that never progressed to ARDS. TCA should be added to the list of drugs associated with the development of ARDS.

journal_name

Radiology

journal_title

Radiology

authors

Varnell RM,Godwin JD,Richardson ML,Vincent JM

doi

10.1148/radiology.170.3.2916020

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

667-70

issue

3 Pt 1

eissn

0033-8419

issn

1527-1315

journal_volume

170

pub_type

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