Characterization of female breast lesions from multi-wavelength time-resolved optical mammography.

Abstract:

:Characterization of both malignant and benign lesions in the female breast is presented as the result of a clinical study that involved more than 190 subjects in the framework of the OPTIMAMM European project. All the subjects underwent optical mammography, by means of a multi-wavelength time-resolved mammograph, in the range 637-985 nm. Optical images were processed by applying a perturbation model, relying on a nonlinear approximation of time-resolved transmittance curves in the presence of an inclusion, with the aim of estimating the major tissue constituents (i.e. oxy- and deoxy-haemoglobin, lipid and water) and structural parameters (linked to dimension and density of the scatterer centres) for both the lesion area and the surrounding tissue. The critical factors for the application of the perturbation model on in vivo data are also discussed. Forty-six malignant and 68 benign lesions were analysed. A subset of 32 cancers, 40 cysts and 14 fibroadenomas were found reliable for the perturbation analysis. For cancers, we show a higher blood content with respect to the surrounding tissue, while cysts are characterized by a lower concentration of scattering centres with respect to the surrounding tissue. For fibroadenomas, the low number of cases does not allow any definite conclusions.

journal_name

Phys Med Biol

authors

Spinelli L,Torricelli A,Pifferi A,Taroni P,Danesini G,Cubeddu R

doi

10.1088/0031-9155/50/11/004

subject

Has Abstract

pub_date

2005-06-07 00:00:00

pages

2489-502

issue

11

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(05)95747-3

journal_volume

50

pub_type

杂志文章
  • Low-frequency conductivity tensor imaging with a single current injection using DT-MREIT.

    abstract::Diffusion tensor - magnetic resonance electrical impedance tomography (DT-MREIT) is an imaging modality to obtain low-frequency anisotropic conductivity distribution employing diffusion tensor imaging (DTI) and magnetic resonance electrical impedance tomography (MREIT) techniques. DT-MREIT is based on the linear relat...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abddcf

    authors: Sadighi M,Sisman M,Acikgoz BC,Eroglu HH,Eyuboglu BM

    更新日期:2021-01-20 00:00:00

  • Intermittent cryogen spray cooling for optimal heat extraction during dermatologic laser treatment.

    abstract::Fast heat extraction is critically important to obtain the maximal benefit of cryogen spray cooling (CSC) during laser therapy of shallow skin lesions, such as port wine stain birthmarks. However, a film of liquid cryogen can build up on the skin surface, impairing heat transfer due to the relatively low thermal condu...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/47/18/301

    authors: Majaron B,Svaasand LO,Aguilar G,Nelson JS

    更新日期:2002-09-21 00:00:00

  • Reply to comment on 'origins of the changing detector response in small megavoltage photon radiation fields'.

    abstract::Andreo and Benmakhlouf (2017 Phys. Med. Biol. 62 1518-32) have disputed a finding of Scott et al (2012 Phys. Med. Biol. 57 4461-76) that the variation with field-size of the response of small ion chambers and solid-state dosimeters in small megavoltage photon radiation fields can largely be attributed to density. Furt...

    journal_title:Physics in medicine and biology

    pub_type: 评论,杂志文章

    doi:10.1088/1361-6560/aae0e4

    authors: Fenwick JD,Georgiou G,Rowbottom CG,Underwood TSA,Kumar S

    更新日期:2018-10-03 00:00:00

  • A novel approach with dual-sampling convolutional neural network for ultrasound image classification of breast tumors.

    abstract::Breast cancer is one of the leading causes of female cancer deaths. Early diagnosis with prophylactic may improve the patients' prognosis. So far ultrasound (US) imaging is a popular method in breast cancer diagnosis. However, its accuracy is bounded to traditional handcrafted feature methods and expertise. A novel me...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abc5c7

    authors: Xie J,Song X,Zhang W,Dong Q,Wang Y,Li F,Wan C

    更新日期:2020-10-29 00:00:00

  • Integration of dynamic contrast-enhanced magnetic resonance imaging and T2-weighted imaging radiomic features by a canonical correlation analysis-based feature fusion method to predict histological grade in ductal breast carcinoma.

    abstract::Tumour histological grade has prognostic implications in breast cancer. Tumour features in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and T2-weighted (T2W) imaging can provide related and complementary information in the analysis of breast lesions to improve MRI-based histological status prediction...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab3fd3

    authors: Fan M,Liu Z,Xie S,Xu M,Wang S,Gao X,Li L

    更新日期:2019-10-23 00:00:00

  • Analytical modeling of relative luminescence efficiency of Al2O3:C optically stimulated luminescence detectors exposed to high-energy heavy charged particles.

    abstract::The objective of this work is to test analytical models to calculate the luminescence efficiency of Al(2)O(3):C optically stimulated luminescence detectors (OSLDs) exposed to heavy charged particles with energies relevant to space dosimetry and particle therapy. We used the track structure model to obtain an analytica...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/2/437

    authors: Sawakuchi GO,Yukihara EG

    更新日期:2012-01-21 00:00:00

  • A static beam delivery device for fast scanning proton arc-therapy.

    abstract::Arc-therapy is a dose delivery technique regularly applied in photon radiation therapy, and is currently subject of great interest for proton therapy as well. In this technique, proton beams are aimed at a tumor from different continuous ranges of incident directions (so called "arcs"). This technique can potentially ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abe02b

    authors: Nesteruk KP,Bolsi A,Lomax AJ,Meer D,van de Water S,Schippers JM

    更新日期:2021-01-26 00:00:00

  • Assessment of the effects of pixel loss on image quality in direct digital radiography.

    abstract::Modern digital radiographic 'flat panel' detectors can exhibit a progressive form of image degradation arising from non-functioning pixels. The effect of these 'dead pixels' on the quantitive image quality measures of modulation transfer function (MTF), noise power spectrum (NPS) and detective quantum efficiency (DQE)...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/6/008

    authors: Padgett R,Kotre CJ

    更新日期:2004-03-21 00:00:00

  • Automatic classification of dental artifact status for efficient image veracity checks: effects of image resolution and convolutional neural network depth.

    abstract::Enabling automated pipelines, image analysis and big data methodology in cancer clinics requires thorough understanding of the data. Automated quality assurance steps could improve the efficiency and robustness of these methods by verifying possible data biases. In particular, in head and neck (H&N) computed-tomograph...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab5427

    authors: Welch ML,McIntosh C,Purdie TG,Wee L,Traverso A,Dekker A,Haibe-Kains B,Jaffray DA

    更新日期:2020-01-10 00:00:00

  • Superpixel-based and boundary-sensitive convolutional neural network for automated liver segmentation.

    abstract::Segmentation of liver in abdominal computed tomography (CT) is an important step for radiation therapy planning of hepatocellular carcinoma. Practically, a fully automatic segmentation of liver remains challenging because of low soft tissue contrast between liver and its surrounding organs, and its highly deformable s...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aabd19

    authors: Qin W,Wu J,Han F,Yuan Y,Zhao W,Ibragimov B,Gu J,Xing L

    更新日期:2018-05-04 00:00:00

  • Respiratory motion prediction by using the adaptive neuro fuzzy inference system (ANFIS).

    abstract::The quality of radiation therapy delivered for treating cancer patients is related to set-up errors and organ motion. Due to the margins needed to ensure adequate target coverage, many breast cancer patients have been shown to develop late side effects such as pneumonitis and cardiac damage. Breathing-adapted radiatio...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/19/020

    authors: Kakar M,Nyström H,Aarup LR,Nøttrup TJ,Olsen DR

    更新日期:2005-10-07 00:00:00

  • CT reconstruction algorithm for a dental panoramic x-ray unit.

    abstract::A variable Jacobian and weighted backprojection algorithm, used for medical CT, was adapted to perform CT reconstructions on data obtained with a dental panoramic x-ray unit. A detector array, fitted to the unit for the purpose of acquiring digital panoramic radiographs, was used to collect the data. Compensations wer...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/37/12/001

    authors: Lee MD,Waggener RG,McDavid WD,Dove SB,Welander U,Tronje G

    更新日期:1992-12-01 00:00:00

  • Achieving reliable coincidence resolving time measurement of PET detectors using multichannel waveform digitizer based on DRS4 chip.

    abstract::Coincidence resolving time (CRT) is one of the most important physical-performance measures for positron emission tomography (PET), as reconstruction with accurate time-of-flight information enhances the lesion detectability in patient studies. Accordingly, various PET detector designs and high-performance front-end r...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aaf0bb

    authors: Park H,Lee S,Ko GB,Lee JS

    更新日期:2018-12-10 00:00:00

  • The impact of calibration phantom errors on dual-energy digital mammography.

    abstract::Microcalcification is one of the earliest and main indicators of breast cancer. Because dual-energy digital mammography could suppress the contrast between the adipose and glandular tissues of the breast, it is considered a promising technique that will improve the detection of microcalcification. In dual-energy digit...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/22/004

    authors: Mou X,Chen X,Sun L,Yu H,Ji Z,Zhang L

    更新日期:2008-11-21 00:00:00

  • The role of trapped bubbles in kidney stone detection with the color Doppler ultrasound twinkling artifact.

    abstract::The color Doppler ultrasound twinkling artifact, which highlights kidney stones with rapidly changing color, has the potential to improve stone detection; however, its inconsistent appearance has limited its clinical utility. Recently, it was proposed stable crevice bubbles on the kidney stone surface cause twinkling;...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa9a2f

    authors: Simon JC,Sapozhnikov OA,Kreider W,Breshock M,Williams JC,Bailey MR

    更新日期:2018-01-09 00:00:00

  • Treatment time reduction for large thermal lesions by using a multiple 1D ultrasound phased array system.

    abstract::To generate large thermal lesions in ultrasound thermal therapy, cooling intermissions are usually introduced during the treatment to prevent near-field heating, which leads to a long treatment time. A possible strategy to shorten the total treatment time is to eliminate the cooling intermissions. In this study, the t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/48/9/307

    authors: Liu HL,Chen YY,Yen JY,Lin WL

    更新日期:2003-05-07 00:00:00

  • Comments on 'Calculation of water equivalent thickness of materials of arbitrary density, elemental composition and thickness in proton beam irradiation'.

    abstract::We comment on a previous article by Zhang and Newhauser (2009 Phys. Med. Biol. 54 1383-95) which presents several approximate ways of computing the water equivalent of an arbitrary degrader. First, we present a simple exact method which depends only on the range-energy relation of water and of the degrader material. S...

    journal_title:Physics in medicine and biology

    pub_type: 评论,信件

    doi:10.1088/0031-9155/55/9/L01

    authors: Gottschalk B

    更新日期:2010-05-07 00:00:00

  • Modelling simple helically delivered dose distributions.

    abstract::In a previous paper, we described quality assurance procedures for Hi-Art helical tomotherapy machines. Here, we develop further some ideas discussed briefly in that paper. Simple helically generated dose distributions are modelled, and relationships between these dose distributions and underlying characteristics of H...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/7/013

    authors: Fenwick JD,Tomé WA,Kissick MW,Mackie TR

    更新日期:2005-04-07 00:00:00

  • The impact of morphology on light transport in cancellous bone.

    abstract::In recent years, optical techniques based on diffusion approximation have demonstrated their ability to gain rich spectral information about bone. However, these methods normally assume homogeneity, while cancellous bone and marrow form a highly heterogeneous two-phase medium. This paper studies the limitations of thi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/17/003

    authors: Margallo-Balbás E,Taroni P,Pifferi A,Koolstra JH,v Ruijven LJ,French PJ

    更新日期:2010-09-07 00:00:00

  • Effective energy resolution and scatter rejection in nuclear medicine.

    abstract::All available imaging devices in nuclear medicine have finite energy resolution. This leads to inclusion of scattered radiation, which in turn degrades the image quality. Different scatter correction schemes therefore try to eliminate the effect of scattered radiation. On the other hand, improvement of the camera's in...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/34/1/008

    authors: Wirth V

    更新日期:1989-01-01 00:00:00

  • Simultaneous minimization of leaf travel distance and tongue-and-groove effect for segmental intensity-modulated radiation therapy.

    abstract::This paper introduces a method to simultaneously minimize the leaf travel distance and the tongue-and-groove effect for IMRT leaf sequences to be delivered in segmental mode. The basic idea is to add a large enough number of openings through cutting or splitting existing openings for those leaf pairs with openings few...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/23/009

    authors: Dai J,Que W

    更新日期:2004-12-07 00:00:00

  • Improving single-event proton CT by removing nuclear interaction events within the energy/range detector.

    abstract::Data filtering is crucial for accurate relative stopping power (RSP) reconstruction in proton CT (pCT). In this work, we assess different filters and their performance for the US pCT collaboration prototype pCT system in Monte Carlo (MC) simulations. The potential of using the recently proposed [Formula: see text]-E f...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab2671

    authors: Volz L,Piersimoni P,Johnson RP,Bashkirov VA,Schulte RW,Seco J

    更新日期:2019-08-01 00:00:00

  • Experimental study on the influence of the central electrode in Farmer-type ionization chambers.

    abstract::In the IAEA TRS-381 protocol, k(cel) and p(cel) account for the central electrode perturbation during the air kerma chamber calibration and the in-phantom measurements. The values of these correction factors are based mainly on Monte Carlo simulations. In the present work experimental data on k(cel) and p(cel) for the...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/44/5/315

    authors: Palm A,Mattsson O

    更新日期:1999-05-01 00:00:00

  • Dose conversion coefficients for CT examinations of adults with automatic tube current modulation.

    abstract::Automatic tube current modulation (TCM) is used in modern CT devices. This is implemented in the numerical calculation of dose conversion coefficients for CT examinations. For four models of adults, the female and male reference models of ICRP and ICRU and a lighter and a heavier female model, dose conversion coeffici...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/20/013

    authors: Schlattl H,Zankl M,Becker J,Hoeschen C

    更新日期:2010-10-21 00:00:00

  • Comparison of two respiration monitoring systems for 4D imaging with a Siemens CT using a new dynamic breathing phantom.

    abstract::Four-dimensional computed tomography (4D-CT) requires breathing information from the patient, and for this, several systems are available. Testing of these systems, under realistic conditions, requires a phantom with a moving target and an expandable outer contour. An anthropomorphic phantom was developed to simulate ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/9/N131

    authors: Vásquez AC,Runz A,Echner G,Sroka-Perez G,Karger CP

    更新日期:2012-05-07 00:00:00

  • A mathematical model for predicting the changes of non-small cell lung cancer based on tumor mass during radiotherapy.

    abstract::This study aims to build a feasible mathematical model to analyze the mass evolution of NSCLC during standard fractionated radiotherapy. Seventy-three cases of NSCLC who were received radiotherapy with prescription dose of 2 Gy  ×  30 fx were selected retrospectively and divided into adenocarcinoma (ADC) group and squ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab47c0

    authors: Chen J,Wang K,Jian J,Zhang W

    更新日期:2019-11-26 00:00:00

  • Comparison of manual and automatic segmentation methods for brain structures in the presence of space-occupying lesions: a multi-expert study.

    abstract::The purpose of this work was to characterize expert variation in segmentation of intracranial structures pertinent to radiation therapy, and to assess a registration-driven atlas-based segmentation algorithm in that context. Eight experts were recruited to segment the brainstem, optic chiasm, optic nerves, and eyes, o...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/14/021

    authors: Deeley MA,Chen A,Datteri R,Noble JH,Cmelak AJ,Donnelly EF,Malcolm AW,Moretti L,Jaboin J,Niermann K,Yang ES,Yu DS,Yei F,Koyama T,Ding GX,Dawant BM

    更新日期:2011-07-21 00:00:00

  • Regional compensation for statistical maximum likelihood reconstruction error of PET image pixels.

    abstract::In positron emission tomography (PET), there is an increasing interest in studying not only the regional mean tracer concentration, but its variation arising from local differences in physiology, the tissue heterogeneity. However, in reconstructed images this physiological variation is shadowed by a large reconstructi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/14/4849

    authors: Forma J,Niemi JA,Ruotsalainen U

    更新日期:2013-07-21 00:00:00

  • ICRP Publication 116--the first ICRP/ICRU application of the male and female adult reference computational phantoms.

    abstract::ICRP Publication 116 on 'Conversion coefficients for radiological protection quantities for external radiation exposures', provides fluence-to-dose conversion coefficients for organ-absorbed doses and effective dose for various types of external exposures (ICRP 2010 ICRP Publication 116). The publication supersedes th...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/18/5209

    authors: Petoussi-Henss N,Bolch WE,Eckerman KF,Endo A,Hertel N,Hunt J,Menzel HG,Pelliccioni M,Schlattl H,Zankl M

    更新日期:2014-09-21 00:00:00

  • Wavelet-packet-based texture analysis for differentiation between benign and malignant liver tumours in ultrasound images.

    abstract::The purpose of this study was to apply a novel method of multiscale echo texture analysis for distinguishing benign (hemangiomas) from malignant (hepatocellular carcinomas (HCCs) and metastases) focal liver lesions in B-mode ultrasound images. In this method, regions of interest (ROIs) extracted from within the lesion...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/48/22/008

    authors: Yoshida H,Casalino DD,Keserci B,Coskun A,Ozturk O,Savranlar A

    更新日期:2003-11-21 00:00:00