Perinatal manifestations of maternal yellow nail syndrome.

Abstract:

:A term female firstborn infant had unexplained nonimmune fetal hydrops and recurrent left chylothorax at 4 weeks of age. A few months before conception, her mother had had acute dystrophic nail changes and is being treated for recurrent sinusitis, bronchiectasis, and a deficiency of serum IgG2. We suggest that they both suffer from a dominantly inherited congenital lymphedema syndrome known as 'yellow nail dystrophy.' Prenatal manifestation of this disorder has not been reported previously. The child's anthropometric and neurological development was normal at 1 year of age, whereas mild ankle edema and marbling of the skin of the limbs were salient clinical findings. Inherited lymphedema leading to nonimmune fetal hydrops also has been recognized in chromosomal disorders, Noonan's syndrome, multiple pterygium syndrome, pulmonary lymphangiectasis, and mixed-vessel lymphatic dysfunction. Indicators of parental lymphedema are not on record in those instances.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Govaert P,Leroy JG,Pauwels R,Vanhaesebrouck P,De Praeter C,Van Kets H,Goeteyn M

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

1016-8

issue

6 Pt 1

eissn

0031-4005

issn

1098-4275

journal_volume

89

pub_type

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