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Sildenafil citrate treatment for erectile dysfunction after kidney transplantation.

Abstract：

OBJECTIVE:Our goal was to analyze the morbidity of organic erectile dysfunction (ED) in kidney-transplant patients and to evaluate the efficacy and reliability of sildenafil citrate treatment. METHOD:Sixty-five ED patients with normal graft function for 3 to 12 months after kidney transplantation were involved in our study. Erectile dysfunction was diagnosed in all the patients by the International Index of Erectile Dysfunction (IIEF). Among them, 10 patients were in light degree; 32 patients in moderate degree, and 23 patients in severe degree according to IIEF score. All of the patients underwent medical history, physical and chemical examinations. In each patient, the IIEF score, blood urea nitrogen, creatinine, and trough concentrations of cyclosporine were compared before and after taking sildenafil citrate at an initial dose of 50 mg every night. RESULTS:Twenty-six patients without ED before transplantation suffered ED after the operation, and 32 patients with ED before transplantation noticed worsening. Taking sildenafil citrate was effective in 53 patients (81.54%). There were no statistical differences in blood urea nitrogen, creatinine, or trough concentrations of cyclosporine in patients before and after sildenafil treatment. CONCLUSIONS:The morbidity of organic erectile dysfunction increased after transplantation. Sildenafil citrate treatment for ED in kidney-transplant patients was effective and safe. Graft function and trough concentrations of cyclosporine were not affected by sildenafil citrate.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Zhang Y,Guan DL,Ou TW,Wang Y,Chen X,Xing NZ,Zhang XD,Yang Y

doi

10.1016/j.transproceed.2005.03.026

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

2100-3

issue

5

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)00263-0

journal_volume

37

pub_type

临床试验,杂志文章

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