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Pulmonary embolism: a fatal complication of arterial chemoembolization for advanced hepatocellular carcinoma.

Abstract：

:The case of a child with advanced hepatocellular carcinoma that did not respond to systemic chemotherapy is presented. Three courses of chemoembolization (hepatic arterial chemoembolization) were given, with partial tumor response. The hepatic artery was cannulated via the femoral artery using the Seldinger technique. Arteriography was performed, and chemoembolization suspension (cisplatin + doxorubicin + mitomycin mixed with Lipiodol) was injected. After the third hepatic arterial chemoembolization, the patient developed fatal pulmonary oil embolism. Hepatic arterial chemoembolization seems to be a useful method for treatment of high-risk hepatocellular carcinoma cases, which can induce responses, even in metastatic patients refractory to standard systemic chemotherapy. However, it may result in pulmonary embolism, which is a potentially fatal complication. In children, Lipiodol should be used as an embolizing material and cytostatic carrier with extreme care. Consideration should be given to replacing it with other materials, including albumin or collagen.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Czauderna P,Zbrzezniak G,Narozanski W,Sznurkowska K,Skoczylas-Stoba B,Stoba C

doi

10.1016/j.jpedsurg.2005.06.011

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

1647-50

issue

10

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(05)00508-7

journal_volume

40

pub_type

杂志文章

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