当前位置： SCI文献检索 > JOURNAL OF PEDIATRIC SURGERY期刊下所有文献 > The role of tissue plasminogen activator in the management of complex intra-abdominal abscesses in children.

The role of tissue plasminogen activator in the management of complex intra-abdominal abscesses in children.

Abstract：

OBJECTIVE:The objective of this study is to assess the safety of fibrinolytic therapy using tissue plasminogen activator (tPA) in children with complex intra-abdominal abscesses. SUMMARY BACKGROUND DATA:Intra-abdominal abscesses are common in children. Antibiotics and percutaneous drainage are the mainstays of treatment, but drainage may be less effective when the fluid is thick or septated. Fibrinolytic therapy using tPA is effective in a rat model of intra-abdominal abscesses, has recently been reported for the treatment of intra-abdominal abscesses in adults, and is commonly used in the treatment of empyema in children. METHODS:This is a retrospective review of all patients over a 10-year period who had intra-abdominal collections managed with tPA abscess drainage. RESULTS:Sixty-four children had a total of 66 drains placed and 92 doses of tPA. Appendicitis was the cause of the abscesses in 52 of 64 children. Mean length of stay pre-tPA was 11.7 ± 7.63 days, mean time from drain insertion to tPA was 4.3 ± 3.78 days, and mean time from tPA to discharge was 8.6 ± 8.85 days. Thirty patients underwent an operation before tPA administration. No patients experienced bleeding complications, anastomotic or appendiceal stump leak, or wound dehiscence after the administration of tPA, and no patients had abnormalities in coagulation studies related to tPA administration. One child died of sepsis. CONCLUSIONS:Tissue plasminogen activator is safe for the management of thick or septated intra-abdominal abscesses in children. A prospective controlled study will be needed to evaluate the efficacy of this technique.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Shawyer AC,Amaral JG,Langer JC

doi

10.1016/j.jpedsurg.2011.12.006

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

1380-4

issue

7

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(11)01134-1

journal_volume

47

pub_type

杂志文章

相关文献

JOURNAL OF PEDIATRIC SURGERY文献大全
  • Bevacizumab and interferon reduce venous recanalization following sclerotherapy.

    abstract：PURPOSE:The treatment of venous malformations is difficult because these lesions frequently recur after resection or sclerotherapy. The purpose of this study was to determine whether recanalization of sclerosed venous lumens could be prevented with systemic angiogenic inhibition using bevacizumab or peginterferon alfa-...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2016.06.009

    authors： Kulungowski AM,Hassanein AH,Foster CC,Greene AK,Fishman SJ

    更新日期：2016-10-01 00:00:00

  • Transient antiphospholipid syndrome in an infant with segmental small bowel infarction.

    abstract：:The clinical picture of venous or arterial thrombosis in the presence of circulating antiphospholipid antibodies is referred to as the antiphospholipid syndrome. A 5-month-old baby girl who was quite healthy so far was referred to our clinic with irritability, vomiting, and abdominal distension for 30 hours. Surgical ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2003.09.026

    authors： Güvenç BH,Sarper N,Tuzlaci A,Günaltay N

    更新日期：2004-01-01 00:00:00

  • Improving survival for patients with high-risk congenital diaphragmatic hernia by using extracorporeal membrane oxygenation.

    abstract：:The benefit of extracorporeal membrane oxygenation (ECMO) in cases of high-risk congenital diaphragmatic hernia (CDH) was studied by comparing pre-ECMO (1987-1990) and post-ECMO (1991-1994) 3-month survival statistics. Fifty-five CDH patients who presented in respiratory distress within 6 hours after birth were referr...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/0022-3468(95)90408-5

    authors： vd Staak FH,de Haan AF,Geven WB,Doesburg WH,Festen C

    更新日期：1995-10-01 00:00:00

  • Effect of anti-alpha-fetoprotein serum on human hepatoblastoma.

    abstract：:There is no definitive treatment of hepatoblastoma. Except for radical resection, the prognosis of unresectable cases remains pessimistic. Therefore, the development of new anticancer drugs for this tumor is urgently needed. Using the human hepatoblastoma cell line (c-HB-3) we demonstrated that horse anti-alpha-fetopr...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(84)80107-4

    authors： Hata Y,Uchino J,Sasaki F,Une Y,Naito H,Sato K,Kukita K,Sano H,Kasai Y,Tsukada Y

    更新日期：1984-10-01 00:00:00

  • A prospective randomized double-blind trial of bolus urokinase in the treatment of established Hickman catheter sepsis in children.

    abstract：BACKGROUND:The incidence of Hickman catheter sepsis is 10% to 40%, with resultant catheter loss in one third of infections. Urokinase causes dissolution of colonized intracatheter fibrin thrombi and may improve salvage. STUDY AIMS:To evaluate the efficacy of 12-hour-interval slow-push urokinase infusion in addition to...

    journal_title：Journal of pediatric surgery

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0022-3468(94)90359-x

    authors： La Quaglia MP,Caldwell C,Lucas A,Corbally M,Heller G,Steinherz L,Brown AE,Groeger J,Exelby PR

    更新日期：1994-06-01 00:00:00

  • Urodynamic performance in boys with Y-type urethral duplication.

    abstract：PURPOSE:The aim of this study was to elucidate the urodynamic features of patients with Y-type urethral duplication. METHODS:Patients with Y-type urethral duplication were retrospectively analyzed. Clinical presentation, urodynamic findings, surgical methods, and treatment outcomes were reviewed. RESULTS:From 2014 to...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2017.06.001

    authors： Zhang Y,Qu Y,Jiao L,Zhang W,Sun N,Tian J,Li M,Song H

    更新日期：2018-07-01 00:00:00

  • Juvenile granulosa cell tumor of the testis: report of two cases in newborns.

    abstract：:Two juvenile granulosa cell tumors in the testes of two newborns are described. The lesion, though rare, should be considered whenever a cystic testicular mass is encountered in newborns or young infants. Orchidectomy is the only treatment required because local recurrence or metastases have never been observed. Karyo...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(97)90025-7

    authors： Chan YF,Restall P,Kimble R

    更新日期：1997-05-01 00:00:00

  • Fetal hydronephrosis: selection and surgical repair.

    abstract：:Newly developed diagnostic techniques allowed us to select a fetus with potentially reversible renal damage from the usually fatal group with bilateral hydronephrosis and severe oligohydramnios early in gestation. Fetal surgery to marsupialize the fetal bladder at 24 weeks gestation restored normal amniotic fluid dyna...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(87)80221-x

    authors： Harrison MR,Golbus MS,Filly RA,Anderson RL,Flake AW,Rosen M,Huff RW

    更新日期：1987-06-01 00:00:00

  • Cachectin/tumor necrosis factor production by fetal and newborn rat hepatic macrophages.

    abstract：:The capacity of fetal and newborn hepatic macrophages to produce cachectin/tumor necrosis factor (TNF) has not been previously examined. The role that TNF plays in newborn infection is also unknown. In the present report, fetal and newborn rat hepatic macrophages have been maintained in short-term tissue culture, and ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(89)80296-9

    authors： Silen ML,Hesse DG,Felsen D,Moldawer LL,Calvano SE,Seniuk S,Cerami A,Lowry SF

    更新日期：1989-01-01 00:00:00

  • Pediatric laparoscopic splenectomy.

    abstract：:We report our initial experience and describe the operative technique used in three patients who underwent laparoscopic splenectomy for hematologic disorders between September 1991 and February 1992. No early or late complications have been found at an average follow-up of 9 months. All have remained asymptomatic and ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/0022-3468(93)90033-h

    authors： Tulman S,Holcomb GW 3rd,Karamanoukian HL,Reynhout J

    更新日期：1993-05-01 00:00:00

  • Successful surgical treatment of two cases of congenital chylous ascites.

    abstract：:The authors report on 2 patients with congenital chylous ascites who underwent successful lymphatic duct ligation after a laparoscopic lymphoid dye test. Fetal ascites had been detected in both cases, and both babies were born with marked abdominal swelling. Given that conservative treatment by medium-chain triglyceri...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1053/jpsu.2001.27973

    authors： Mitsunaga T,Yoshida H,Iwai J,Matsunaga T,Kouchi K,Ohtsuka Y,Okada T,Hishiki T,Ohnuma N

    更新日期：2001-11-01 00:00:00

  • Esophageal tracheoplasty for congenital tracheal stenosis.

    abstract：:Two infants with congenital long tracheal stenosis underwent operation by means of an esophageal tracheoplasty. The first patient had previously undergone tracheal reconstruction using the pericardium. Although ventilation improved somewhat following this procedure, the pericardial patch suddenly ruptured 12 days afte...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/0022-3468(92)90468-m

    authors： Sasaki S,Hara F,Ohwa T,Eguchi T,Masaoka A

    更新日期：1992-05-01 00:00:00

  • Juvenile gastrointestinal polyposis or the infantile Cronkhite-Canada syndrome.

    abstract：:This is a report of a case of juvenile gastrointestinal polyposis consisting of widespread juvenile polyps encountered from the stomach into the rectum. Only few cases have been reported, and extra intestinal manifestations include clubbing of fingers, macrocephaly, hypotonia, hepatosplenomegaly, anemia, and protein-l...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(86)80102-6

    authors： Scharf GM,Becker JH,Laage NJ

    更新日期：1986-11-01 00:00:00

  • Comparison of transumbilical laparoscopic-assisted appendectomy versus single incision laparoscopic appendectomy in children: which is the better surgical option?

    abstract：BACKGROUND:Transumbilical laparoscopic-assisted appendectomy (TULA) is a single incision technique that exteriorizes the appendix through the umbilicus. The aim of this study was to compare the surgical outcomes of TULA with SILA in pediatric appendicitis. METHODS:A retrospective review of medical records between Apri...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2015.12.013

    authors： Boo YJ,Lee Y,Lee JS

    更新日期：2016-08-01 00:00:00

  • Recurrent colocolic intussusception in a child with hereditary angioneurotic edema: reduction by air enema.

    abstract：:The authors discuss a case of hereditary angioneurotic edema in a child presenting with recurrent episodes of colocolic intussusception, each successfully reduced by air enema. Although additional manifestations of vasogenic edema are potential risks of the procedure, these were not encountered. ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2004.03.075

    authors： Pritzker HA,Levin TL,Weinberg G

    更新日期：2004-07-01 00:00:00

  • Plication of the diaphragm for symptomatic phrenic nerve paralysis.

    abstract：:Paralysis of the diaphragm in infants may produce severe respiratory difficulty because of the paradoxic motion of the affected diaphragm and shift of a mobile mediastinum to the contralateral side. Six infants with diaphragmatic paralysis and severe respiratory distress underwent plication of the diaphragm by a simpl...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(78)80397-2

    authors： Schwartz MZ,Filler RM

    更新日期：1978-06-01 00:00:00

  • Neonatal meconium obstruction in the ileum without mucoviscidosis.

    abstract：:Two newborns with intestinal obstruction of the terminal ileum without mucoviscidosis were cured by Gastrografin enema. A further case of a premature infant showed, at autopsy, a large intestine containing normal meconium, but an ileum which was plugged with tenacious meconium containing PAS-positive and alcian blue-n...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(78)80308-x

    authors： Shigemoto H,Endo S,Isomoto T,Sano K,Taguchi K

    更新日期：1978-10-01 00:00:00

  • The sea, stingers, and surgeons: the surgeon's role in prevention, first aid, and management of marine envenomations.

    abstract：:Marine envenomations are the statistical price that humankind pays for intruding into the aquatic domain. Individual risk can be reduced by knowledge and prudence. If envenomations do occur, lives can be saved, complications prevented, and convalescence facilitated by knowledge of and interest in these fascinating cre...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章,评审

    doi：10.1016/0022-3468(95)90622-3

    authors： Pearn J

    更新日期：1995-01-01 00:00:00

  • Idiopathic constipation in childhood is associated with thickening of the internal anal sphincter.

    abstract：:This study was undertaken to search for a rational basis for the use of anal dilatation and internal sphincterotomy as the treatment for chronic intractable constipation in children. Sixteen children, age 5 months to 13 years, who had constipation resistant to conservative treatment were compared with 39 age-matched c...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(97)90395-x

    authors： Hosie GP,Spitz L

    更新日期：1997-07-01 00:00:00

  • Effects of prenatal vitamins A, E, and C on the hypoplastic hearts of fetal rats with diaphragmatic hernia.

    abstract：BACKGROUND/AIM:Nitrofen induces heart hypoplasia together with congenital diaphragmatic hernia (CDH) in rats. Intracellular oxidative stress might be one of the mechanisms of action of the teratogen, and vitamin A has been shown to reverse in part these effects when administered simultaneously or shortly after it. This...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2005.05.009

    authors： González-Reyes S,Martínez L,Tovar JA

    更新日期：2005-08-01 00:00:00

  • Increased capture of pediatric surgical complications utilizing a novel case-log web application to enhance quality improvement.

    abstract：PURPOSE:Documenting surgical complications is limited by multiple barriers and is not fostered in the electronic health record. Tracking complications is essential for quality improvement (QI) and required for board certification. Current registry platforms do not facilitate meaningful complication reporting. We develo...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2016.10.036

    authors： Fisher JC,Kuenzler KA,Tomita SS,Sinha P,Shah P,Ginsburg HB

    更新日期：2017-01-01 00:00:00

  • Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes.

    abstract：PURPOSE:In the setting of gastroschisis, the clinical significance of prenatal ultrasound findings of secondary changes in bowel appearance remains unknown. The purpose of this study was to correlate prenatal identification of additional gastrointestinal sonographic abnormalities with postnatal clinical outcome. METHO...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2007.09.016

    authors： Badillo AT,Hedrick HL,Wilson RD,Danzer E,Bebbington MW,Johnson MP,Liechty KW,Flake AW,Adzick NS

    更新日期：2008-04-01 00:00:00

  • Adult rhabdomyoma of the esophagus.

    abstract：:Rhabdomyoma is a rare benign tumor of striated muscle origin. Two distinct histologic groups, adult and fetal type, are recognized. So far only 66 cases of extracardiac rhabdomyomas (37 fetal and 29 adult) have been documented in the literature reviewed. The present report details a case of adult rhabdomyoma of the es...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(87)80490-6

    authors： Pai GK,Pai PK,Kamath SM

    更新日期：1987-11-01 00:00:00

  • Heparin-binding EGF-like growth factor is cytoprotective for intestinal epithelial cells exposed to hypoxia.

    abstract：BACKGROUND:During recovery from intestinal ischemic injury, there is rapid growth of intestinal epithelia with regeneration of damaged villi. This study examines the effects of heparin-binding EGF-like growth factor (HB-EGF) on the recovery of intestinal epithelial cells exposed to hypoxia. METHODS:The cytoprotective ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/s0022-3468(98)90517-6

    authors： Pillai SB,Turman MA,Besner GE

    更新日期：1998-07-01 00:00:00

  • Management of pulmonary insufficiency in diaphragmatic hernia using extracorporeal circulation with a membrane oxygenator (ECMO).

    abstract：:Persistent fetal circulation (PFC) causes severe pulmonary insufficiency in patients who have demonstrated adequate lung function following diaphragmatic hernia repair. Patent ductus arteriosus (PDA) ligation corrects this condition, but carries the risk of sudden right ventricular failure. Pharmacologic reversal of P...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/0022-3468(77)90600-5

    authors： German JC,Gazzaniga AB,Amlie R,Huxtable RF,Bartlett RH

    更新日期：1977-12-01 00:00:00

  • Evidence for active Wnt signaling during postresection intestinal adaptation.

    abstract：BACKGROUND:In the intestine, Wnt proteins are powerful regulators of cell proliferation, differentiation, and adhesion. Mutations of the adenomatous polyposis coli (APC) gene elevate nuclear beta-catenin and provoke intestinal tumor formation. We sought to determine whether Wnt signaling is involved in adaptive respons...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2005.03.021

    authors： Bernal NP,Stehr W,Zhang Y,Profitt S,Erwin CR,Warner BW

    更新日期：2005-06-01 00:00:00

  • Renal parenchymal malacoplakia: a different stage of xanthogranulomatous pyelonephritis?

    abstract：:Malacoplakia is a rare inflammatory condition characterized by demonstrative Michaelis-Gutmann bodies, which are foamy histiocytes with distinctive basophilic inclusions. Malacoplakia is caused by the inadequate elimination of bacteria by macrophages or monocytes as a result of defective phagocytic activity. Xanthogra...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2007.05.005

    authors： Yiğiter M,Ilgici D,Celik M,Arda IS,Hiçsönmez A

    更新日期：2007-07-01 00:00:00

  • Predictability model of the need for extracorporeal membrane oxygenation in neonates with meconium aspiration syndrome treated with inhaled nitric oxide.

    abstract：BACKGROUND:As the use of inhaled nitric oxide (iNO) resulted in a decline in the need for extracorporeal membrane oxygenation (ECMO) in neonates with hypoxic respiratory failure, iNO has become an accepted treatment modality even in non-ECMO centers. However, because not all neonates respond to iNO, the timely identifi...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2005.03.061

    authors： Friedlich P,Noori S,Stein J,Shin C,Burns C,Ramanathan R,Seri I

    更新日期：2005-07-01 00:00:00

  • An unusual presentation of a congenital intrahepatic arterioportal fistula in an infant with Down syndrome.

    abstract：:Congenital intrahepatic arterioportal fistula is a rare entity that most often presents with symptoms of portal hypertension and malabsorption. We discuss a patient who presented with distributive shock, congestive heart failure, pulmonary hypertension, ascites, and a history of severe constipation. ...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2010.08.016

    authors： Bogert JN,Potter DD,Crow S,Arteaga GM,Freese DK

    更新日期：2011-01-01 00:00:00

  • Sonographic evaluation of gastrointestinal obstruction in infants: a pictorial essay.

    abstract：:Traditionally, gastrointestinal contrast studies have been the mainstay of evaluating infantile gastrointestinal problems. Because of technological advancements, good ultrasonography (USG) machines can provide high-resolution images with graphic anatomical clarity, especially in infants and children and thus change th...

    journal_title：Journal of pediatric surgery

    pub_type： 杂志文章

    doi：10.1016/j.jpedsurg.2009.05.019

    authors： Maheshwari P,Abograra A,Shamam O

    更新日期：2009-10-01 00:00:00