当前位置： SCI文献检索 > JOURNAL OF PEDIATRIC SURGERY期刊下所有文献 > Ultrasound Elastography as a Non-Invasive Method to Monitor Liver Disease in Children with Short Bowel Syndrome: Updated Results.

Ultrasound Elastography as a Non-Invasive Method to Monitor Liver Disease in Children with Short Bowel Syndrome: Updated Results.

Abstract：

PURPOSE:The purpose of the study was to determine the accuracy of acoustic radiation force impulse (ARFI) ultrasound elastography in assessing the degree of liver disease in children with short bowel syndrome (SBS). METHODS:A prospective observational cohort study of patients with SBS who underwent a liver biopsy and ARFI elastography was performed. Mean shear wave speed (SWS) and stage of fibrosis was evaluated using t-tests. Receiver operating characteristic curves (ROC) were generated and the area under the curves (AUC) estimated in order to assess the accuracy of SWS measurements to discriminate between stages of fibrosis. RESULTS:Thirty-seven paired elastography and biopsy samples from 31 patients were included. The median age was 0.6 years, and 61% were male. There was a significant positive correlation between stage of fibrosis and mean SWS (β=0.16 m/s increase per stage, p=<0.001). ROC analysis revealed that mean SWS had good accuracy for discriminating between mild liver fibrosis (F0-F1) and moderate to severe fibrosis (F2-F4) (AUC=0.80, 95% CI 0.65-0.95). In addition, ROC analysis demonstrated that mean SWS can also accurately discriminate between mild to moderate fibrosis (F0-F2) and more severe fibrosis (F3-F4) (AUC=0.84, 95% CI 0.71-0.96). CONCLUSION:ARFI elastography is an accurate, non-invasive method to monitor liver disease in children with SBS. TYPE OF STUDY:Retrospective Cohort Study LEVEL OF EVIDENCE: II.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Lawrence AE,Dienhart M,Cooper JN,Lodwick D,Lopez JJ,Fung B,Smith S,Warren P,Mezoff E,Balint J,Minneci PC

doi

10.1016/j.jpedsurg.2019.02.039

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

1179-1183

issue

6

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(19)30180-0

journal_volume

54

pub_type

杂志文章

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