Rhabdomyosarcoma of the prostate in childhood: current challenges.


:Since 1978, six boys with prostatic rhabdomyosarcoma have been treated at our institution. Three had localized disease and were managed by initial biopsy, vincristine, actinomycin-D, and cyclophosphamide (VAC) chemotherapy, and bladder-sparing surgery with or without irradiation. Further combination chemotherapy ("pulse" VAC, Adriamycin, VP-16, cisplatin, and ifosfamide) was continued for 20 to 22 months following the induction course. Two boys had microscopic residual disease undetected by frozen section and unresponsive to radiotherapy. Subsequent total cystectomy 4 and 7 months later resulted in eradication of disease. In one patient, preservation of the bladder was achieved at the age of 3 months for 8 years. Artificial sphincter inserted to cure his urinary incontinence failed because of ischemia secondary to cuff compression and scar tissue. He is alive today with a modified Koch pouch urinary diversion. Of the 50% who had metastatic disease at presentation, two were dead within 12 months despite aggressive chemotherapy and irradiation. The third is currently on treatment. Although chemotherapy has markedly improved the prognosis, surgery is still necessary in most cases for cure. Bladder salvage is a desirable goal; however, residual microscopic disease, difficulty with frozen-section disease detection, and poor tissue vascularization for subsequent sphincter replacement remain significant obstacles.


J Pediatr Surg


McLorie GA,Abara OE,Churchill BM,Greenberg M,Mancer K




Has Abstract


1989-10-01 00:00:00














  • Octreotide for chylous effusions in congenital diaphragmatic hernia.

    abstract:BACKGROUND/PURPOSE:Chylothorax is a frequent complication in congenital diaphragmatic hernia (CDH) infants and is associated with significant morbidity. The optimal treatment strategy remains unclear. We hypothesize that octreotide decreases chylous effusions in infants with CDH. METHODS:This is a retrospective study ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Landis MW,Butler D,Lim FY,Keswani S,Frischer J,Haberman B,Kingma PS

    更新日期:2013-11-01 00:00:00

  • Magnetic resonance imaging of abdominal masses in children.

    abstract::Seventeen children with abdominal masses (16 solid and 1 complex cystic) were evaluated by magnetic resonance imaging (MRI). Computed tomography (CT) was also performed in 12 cases. MRI findings were correlated with CT and histopathologic findings. In 10 cases MRI provided more specific diagnostic information than CT....

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Vade A,Azienstein R

    更新日期:1993-01-01 00:00:00

  • Review of bedside surgeon-performed ultrasound in pediatric patients.

    abstract:PURPOSE:Pediatric surgeon performed bedside ultrasound (PSPBUS) is a targeted examination that is diagnostic or therapeutic. The aim of this paper is to review literature involving PSPBUS. METHODS:PSPBUS practices reviewed in this paper include central venous catheter placement, physiologic assessment (volume status a...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审


    authors: Bonasso PC,Dassinger MS,Wyrick DL,Gurien LA,Burford JM,Smith SD

    更新日期:2018-11-01 00:00:00

  • Fetal extraperitoneal rectal perforation: a rare neonatal emergency.

    abstract:PURPOSE:Intraperitoneal bowel perforation may occur in utero as a result of a variety of abnormalities and typically results in sterile meconium ascites, pseudocysts, and/or calcification in the fetus. On the other hand, extraperitoneal bowel perforation in intrauterine life is extremely rare. The object of this report...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,多中心研究


    authors: Pitcher GJ,Davies MR,Bowley DM,Numanoglu A,Rode H

    更新日期:2009-07-01 00:00:00

  • Prepubertal testicular tumors: a single-center experience of 44years.

    abstract:PURPOSE:To present the clinical and histological features of prepubertal testicular tumors (PTTs), the long-term experience of a single institution was reviewed. MATERIALS AND METHODS:A total of 62 prepubertal children who were treated for testicular tumors at Kanagawa Children's Medical Center from 1971 to 2014 were ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Akiyama S,Ito K,Kim WJ,Tanaka Y,Yamazaki Y

    更新日期:2016-08-01 00:00:00

  • Management of giant omphalocele with rapid creation of abdominal domain.

    abstract:BACKGROUND:The management of giant omphaloceles (GO) can be quite difficult when there is absence of abdominal domain. Coverage with delayed closure has been described. We present a technique to create an adequate peritoneal domain. METHODS:This is a retrospective review of our experience using an intraperitoneal tiss...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Foglia R,Kane A,Becker D,Asz-Sigall J,Mychaliska G

    更新日期:2006-04-01 00:00:00

  • Diagnostic accuracy of serum alpha-fetoprotein levels in diagnosing recurrent sacrococcygeal teratoma: A systematic review.

    abstract:BACKGROUND:The incidence of children developing recurrent sacrococcygeal teratoma (SCT) is 2-35%. Serum alpha-fetoprotein (AFP) is often used as a tumor marker for (malignant) recurrences of SCT and could potentially be used during routine follow-up after SCT resection. However, the diagnostic accuracy of serum AFP lev...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: van Heurn LJ,Knipscheer MM,Derikx JPM,van Heurn LWE

    更新日期:2020-09-01 00:00:00

  • The impact of preoperative ultrasound on correct diagnosis of urachal remnants in children.

    abstract:BACKGROUND:Ultrasound is a noninvasive imaging method used widely in urachal diagnostics. This study investigated the effectiveness of ultrasonography in correctly depicting urachal anomalies in children. METHODS:Preoperative ultrasound findings of all patients who were operated on for suspected urachal anomalies betw...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Widni EE,Höllwarth ME,Haxhija EQ

    更新日期:2010-07-01 00:00:00

  • Heterotopic gastric mucosa in the gallbladder: a cause of chronic abdominal pain in a child.

    abstract::A 12-year-old boy presented with a 7-year history of intermittent colicky epigastric pain. Serial abdominal ultrasound studies showed a contracted gallbladder, and single and double dose oral cholecystograms demonstrated nonfunction. All other investigation results were normal. At cholecystectomy, there was a fibrotic...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审


    authors: Lamont N,Winthrop AL,Cole FM,Langer JC,Issenman RM,Finkel KC

    更新日期:1991-11-01 00:00:00

  • Enteral feeding tubes are a reservoir for nosocomial antibiotic-resistant pathogens.

    abstract:BACKGROUND:Patients and their surroundings are known reservoirs for nosocomial pathogens. Enteral feeding tubes and formula are not thought of as reservoirs for nosocomial organisms. METHODS:A prospective observation study was conducted comparing methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resist...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Mehall JR,Kite CA,Gilliam CH,Jackson RJ,Smith SD

    更新日期:2002-07-01 00:00:00

  • Differences in the structure of alpha-fetoprotein and its clinical use in pediatric surgery.

    abstract::Techniques have been studied which distinguish two variants of human alpha-fetoprotein (AFP) on the basis of characteristics of the carbohydrate moiety of this glycoprotein. AFP in serum samples from six children with tumors of yolk sac origin showed little concanavalin-A (Con A) binding. In contrast, Con A binding of...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Tsuchida Y,Kaneko M,Saito S,Endo Y

    更新日期:1985-06-01 00:00:00

  • Endoscopic drainage of pancreatic pseudocysts in children.

    abstract:BACKGROUND/PURPOSE:Symptomatic pancreatic pseudocysts have traditionally been managed with surgical, percutaneous, and, more recently, endoscopic drainage. Although the role of the latter is well defined in the adult population, its utility in children needs to be clarified. The authors reviewed their experience with e...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Al-Shanafey S,Shun A,Williams S

    更新日期:2004-07-01 00:00:00

  • Prevention of fetal bowel allograft rejection by combined treatment with anti-ICAM-1 and anti-LFA-1 antibodies.

    abstract::Prevention and treatment of allograft rejection remain the major issues in clinical small bowel transplantation. New strategies for manipulating immune responses using more powerful immunosuppressive agents continue to be evaluated. The fetal small bowel from BALB/c (H-2d) or C3H/He (H-2k) mice was transplanted into t...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Kato Y,Yamataka A,Yagita H,Bashuda H,Okumura K,Miyano T

    更新日期:1995-07-01 00:00:00

  • Cumulative sum: An individualized proficiency metric for laparoscopic fundamentals.

    abstract:BACKGROUND:A reliable metric of technical proficiency is indispensable to the training of fellows and residents. The purpose of this study was to determine whether cumulative sum (Cusum) has predictive validity in laparoscopic training. We hypothesized that Cusum would be a better predictor of technical ability in fund...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Hu Y,Warren HL,McMurry TL,Goodrich RN,Choi J,Mahmutovic A,Kim H,Rasmussen SK

    更新日期:2016-04-01 00:00:00

  • North American pediatric surgery fellows' preparedness for humanitarian surgery.

    abstract:INTRODUCTION:The overwhelming burden of pediatric surgical need in humanitarian settings has prompted mutual interest between humanitarian organizations and pediatric surgeons. To assess adequate fit, we correlated pediatric surgery fellowship case mix and load with acute pediatric surgical relief efforts in conflict a...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Traynor MD Jr,Trelles M,Hernandez MC,Dominguez LB,Kushner AL,Rivera M,Zielinski MD,Moir CR

    更新日期:2020-10-01 00:00:00

  • Down's syndrome as a factor in the diagnosis, management, and outcome in patients of Morgagni hernia.

    abstract:PURPOSE:The purpose was to study the impact of Down's syndrome (DS) in the diagnosis, management, and outcomes of patients with Morgagni hernia (MH). METHODS:Twenty-two (22) patients with MH treated at a tertiary center were retrospectively studied for history, findings, associated anomalies, referral diagnoses, hospi...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Jetley NK,Al-Assiri AH,Al-Helal AS,Al-Bin Ali AM

    更新日期:2011-04-01 00:00:00

  • Adult rhabdomyoma of the esophagus.

    abstract::Rhabdomyoma is a rare benign tumor of striated muscle origin. Two distinct histologic groups, adult and fetal type, are recognized. So far only 66 cases of extracardiac rhabdomyomas (37 fetal and 29 adult) have been documented in the literature reviewed. The present report details a case of adult rhabdomyoma of the es...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Pai GK,Pai PK,Kamath SM

    更新日期:1987-11-01 00:00:00

  • The role of fine-needle aspiration cytology in children with persistent or suspicious lymphadenopathy.

    abstract:PURPOSE:The aim of this study was (1) To determine the value of fine-needle aspiration cytology (FNAC) in children with persistent or suspicious peripheral lymphadenopathy and (2) to analyze whether a history of previous malignancy influenced the accuracy of FNAC. METHODS:A retrospective study in an Academic Children'...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: van de Schoot L,Aronson DC,Behrendt H,Bras J

    更新日期:2001-01-01 00:00:00

  • Successful medical treatment of two patients with eosinophilic oesophagitis.

    abstract:BACKGROUND/PURPOSE:Significant oesophageal eosinophilia is associated with oesophagitis and gastroesophageal reflux (GER). Eosinophilic oesophagitis is a rare disease that causes thickening of the oesophageal wall, narrowing of the oesophageal lumen, and severe motor disturbance. METHODS AND RESULTS:Two 12 yr-old pati...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: De Agustin JC,Sanz N,Canals MJ,Alvarez E,Morales JL,Soler J,Ollero JC,Vazquez J

    更新日期:2002-02-01 00:00:00

  • Relative value units correlate with pediatric surgeons' operating time: when perceived myth becomes reality.

    abstract:PURPOSE:In 1992, the Congress implemented a Medicare payment system based on relative value units (RVUs). Today, RVUs are increasingly used to determine surgeon reimbursement from Medicare, Medicaid, and private third-party payers. We questioned whether current RVU assignments accurately reflect the quantity of time th...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Little DC,St Peter SD,Calkins CM,Shah SR,Murphy JP,Gatti JM,Gittes GK,Sharp RJ,Andrews WS,Holcomb GW 3rd,Ostlie DJ,Snyder CL

    更新日期:2006-01-01 00:00:00

  • Regional analgesia for postoperative pain in pediatric outpatient surgery.

    abstract::Of 156 children undergoing elective inguinal herniotomy under general anesthesia, 81 also had a regional nerve block using Bupivacaine. All were treated as outpatients and recovery was assessed by postanesthetic room nurses and by interrogating the parents as to the child's behavior at home. It was concluded that the ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Shandling B,Steward DJ

    更新日期:1980-08-01 00:00:00

  • Esophageal bougienage technique for coin ingestion in children.

    abstract::An analysis was performed of 46 consecutive children who received esophageal bougienage for an ingested coin lodged in the esophagus. All patients met the following clinical criteria necessary for performance of this procedure: an acutely ingested single coin, radiographically localized in the esophagus; no previous h...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Bonadio WA,Jona JZ,Glicklich M,Cohen R

    更新日期:1988-10-01 00:00:00

  • Prognostic factors and survival in non-central nervous system rhabdoid tumors.

    abstract:INTRODUCTION:Non-central nervous system (non-CNS) rhabdoid tumors tend to present at a young age and have an extremely aggressive course, with dismal overall survival rates. Inactivation of the tumor suppressor gene SMARCB1 has been shown in rhabdoid tumors regardless of anatomic location, suggesting a common genetic b...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Farber BA,Shukla N,Lim II,Murphy JM,La Quaglia MP

    更新日期:2017-03-01 00:00:00

  • Loop versus divided colostomy for the management of anorectal malformations: a systematic review and meta-analysis.

    abstract:BACKGROUND:The ideal colostomy type for patients with anorectal malformations (ARM) is undetermined. We performed a systematic review and meta-analysis of short-term complications comparing loop and divided colostomies. METHODS:After review registration (PROSPERO: CRD42016036481), multiple databases were searched for ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,meta分析,评审


    authors: Youssef F,Arbash G,Puligandla PS,Baird RJ

    更新日期:2017-05-01 00:00:00

  • Is it necessary to drain all postoperative fluid collections after appendectomy for perforated appendicitis?

    abstract:PURPOSE:Children treated for perforated appendicitis can have significant morbidity. Management often includes looking for and draining postoperative fluid collections. We sought to determine if drainage hastens recovery. METHODS:Children with perforated appendicitis treated with appendectomy from 2006 to 2009 were re...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Piper HG,Derinkuyu B,Koral K,Perez EA,Murphy JT

    更新日期:2011-06-01 00:00:00

  • Surfactant (beractant) therapy for infants with congenital diaphragmatic hernia on ECMO: evidence of persistent surfactant deficiency.

    abstract::Infants with congenital diaphragmatic hernia (CDH) on extracorporeal membrane oxygenation (ECMO) can have initial lung atelectasis which, in survivors, gradually improves over time. To test the hypothesis that these patients could benefit from surfactant therapy, infants with CDH (born at > 34 weeks' gestation) on ECM...

    journal_title:Journal of pediatric surgery

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lotze A,Knight GR,Anderson KD,Hull WM,Whitsett JA,O'Donnell RM,Martin G,Bulas DI,Short BL

    更新日期:1994-03-01 00:00:00

  • Hypocalcemia and hyperphosphatemia after phosphate enema use in a child.

    abstract::The authors present a 3-year-old girl in whom severe hyperphosphatemia and hypocalcemia developed after the administration of three adult-sized hypertonic phosphate enemas. The commonly held notion that these enemas are not absorbed and therefore are systemically inactive is incorrect. With early intervention and trea...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Helikson MA,Parham WA,Tobias JD

    更新日期:1997-08-01 00:00:00

  • Experience in treating congenital esophageal atresia in China.

    abstract:PURPOSE:The aim of the study was to evaluate our recent experience in treating esophageal atresia (EA) and the outcomes observed at a single center for pediatric surgery. MATERIALS AND METHODS:The records of infants with EA from 2006 to 2009 were reviewed. Birth weight, associated anomalies, details of management, com...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Zhang Z,Huang Y,Su P,Wang D,Wang L

    更新日期:2010-10-01 00:00:00

  • Histologic oddities at the porta hepatis in biliary atresia.

    abstract:PURPOSE:Highly unusual histologic findings at the porta hepatis in 3 infants who underwent Kasai portoenterostomy for biliary atresia are reported. METHODS:Portoenterostomy was performed using a standard operative technique. Serial transverse sections of the excised portal plate were examined by light microscopy along...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Stahlschmidt J,Stringer MD,Wyatt J,Davison S,Rajwal S,McClean P

    更新日期:2008-07-01 00:00:00

  • Thoracoscopic repair of oesophageal atresia: experience of 33 patients from two tertiary referral centres.

    abstract:BACKGROUND:With advances in minimally invasive surgery, thoracoscopic repair of oesophageal atresia has become popular in many centres worldwide and indeed has been described as the pinnacle of neonatal surgery. Here, we report our experience in two tertiary referral centres. METHODS:Thoracoscopic technique was introd...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,多中心研究


    authors: Huang J,Tao J,Chen K,Dai K,Tao Q,Chan IH,Chung PH,Lan LC,Tam PK,Wong KK

    更新日期:2012-12-01 00:00:00