A case of microglandular adenocarcinoma of the endometrium.

abstract：OBJECTIVE:Ras gene mutations have been identified in squamous cell carcinomas of the cervix and are associated with advanced-stage tumors. The current study was designed to determine the prevalence of c-Ki-ras mutations in invasive endocervical adenocarcinomas and associations between mutations, HPV status, and known p...

journal_title：Gynecologic oncology

authors： Koulos JP,Wright TC,Mitchell MF,Silva E,Atkinson EN,Richart RM

更新日期：1993-03-01 00:00:00

abstract：:An epidemiologic study of multiple primary malignant neoplasms in endometrial cancer patients in Israel is presented. During the 7-year period of the study, 104 patients (10.3%) out of 1007 patients diagnosed as having endometrial cancer had another primary cancer. There was a significant difference in the incidence o...

journal_title：Gynecologic oncology

authors： Schwartz Z,Ohel G,Birkenfeld A,Anteby SO,Schenker JG

更新日期：1985-09-01 00:00:00

abstract：:Survival rates were computed for 376 women diagnosed with carcinoma of the uterine cervix between 1964 and 1988. The 5-year survival rate for the entire group was 63%. The effect of age at diagnosis, clinical stage, histopathology, year of diagnosis, and screening program attendance was studied by univariate analysis ...

journal_title：Gynecologic oncology

authors： Sigurdsson K,Hrafnkelsson J,Geirsson G,Gudmundsson J,Salvarsdóttir A

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVES:Intraperitoneal (IP) chemotherapy following neoadjuvant chemotherapy (NACT) and interval tumor reductive surgery (TRS) for advanced ovarian cancer is feasible, however, the impact on disease outcomes remains unclear. We compare outcomes of patients treated with IP chemotherapy versus intravenous (IV) chemoth...

journal_title：Gynecologic oncology

authors： Bixel K,Vetter M,Davidson B,Berchuck A,Cohn D,Copeland L,Fowler JM,Havrilesky L,Lee PS,O'Malley DM,Salani R,Valea F,Alvarez Secord A,Backes F

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the influence of surgical debulking performed on patients with Stage IV ovarian cancer and to determine prognostic factors which identify pts who may benefit from aggressive initial surgical debulking. METHODS:A retrospective chart review was conducted (1/1/87-12/31/93). Eligible patients include...

journal_title：Gynecologic oncology

authors： Curtin JP,Malik R,Venkatraman ES,Barakat RR,Hoskins WJ

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To assess trends in guideline-adherent fertility-sparing surgery (GA-FSS) for early-stage cervical cancer relative to Patient Protection and Affordable Care Act (ACA) implementation. METHODS:National Cancer Database patients treated for Stage IA1-IB1 cervical cancer from 2004 to 2016 were included. Multivari...

journal_title：Gynecologic oncology

authors： Sutaria T,Sparks AD,Rao YJ,Lopez-Acevedo M,Long B

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Nicaragua has some of the highest rates of cervical cancer in Latin America and the world. In 2003, the Nicaraguan Ministry of Health, the Central American Institute of Health and the Maria Luisa Ortiz Clinic combined efforts to create an effective remote rural service network, with centralized quality-contr...

journal_title：Gynecologic oncology

authors： Howe SL,Vargas DE,Granada D,Smith JK

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:High tumor dissemination (HTD) is a major risk factor for serious morbidity after primary ovarian cancer (OC) surgery, particularly in medically compromised patients. We performed a pilot study of whether CT findings could predict extent of disease and surgical complexity necessary in advanced OC. METHODS:P...

journal_title：Gynecologic oncology

authors： Glaser G,Torres M,Kim B,Aletti G,Weaver A,Mariani A,Hartmann L,Cliby W

更新日期：2013-08-01 00:00:00

abstract：:Incisional herniae are relatively frequent complications of abdominal incisions. Hernia repair techniques have taken advantage of the strength provided by prosthetic mesh grafts. Subsequent surgery in these patients must incorporate a strategy for managing the mesh material. The goals are adequate exposure for surgery...

journal_title：Gynecologic oncology

authors： Buekers TE,Sorosky JI,Buller RE

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:Collagen gel constitutes a valuable tool for the study of cell-matrix interactions; however, it is sometimes difficult to use the gel, in which tumor and stromal cells are cocultured, for immunohistochemistry, because it is easily broken during the process of fixation and embedding in paraffin, especially aft...

journal_title：Gynecologic oncology

authors： Tanaka R,Saito T,Ashihara K,Nishimura M,Mizumoto H,Kudo R

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:Our purpose was to determine the mRNA and protein expression of cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) in ovarian tumors and normal ovaries of the hen, which is an excellent model for human ovarian cancer. Tissue concentrations of prostaglandin E(2) (PGE2) and PGE2 metabolites were also determi...

journal_title：Gynecologic oncology

authors： Urick ME,Johnson PA

更新日期：2006-11-01 00:00:00

abstract：:Previous herpes simplex virus type 2 (HSV-2) infections are known to predispose women for the development of cervical cancer, but causal relationship between the virus and the cancer has never been proven. Forty-six patients with cervical carcinoma (13 with preinvasive lesions and 33 with various stages of invasive di...

journal_title：Gynecologic oncology

authors： Vass-Sørensen M,Abeler V,Berle E,Pedersen B,Davy M,Thorsby E,Norrild B

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Survivorship and quality of life issues are becoming increasingly relevant in endometrial cancer as a result of the marked increase in incidence of the disease combined with excellent and improving long term survival. OBJECTIVE:The purpose of this study was to evaluate the effect of obesity on quality of li...

journal_title：Gynecologic oncology

authors： Smits A,Lopes A,Das N,Bekkers R,Galaal K

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To determine the antitumor activity and toxicity profile of gemcitabine as second-line chemotherapy in patients with recurrent or persistent uterine leiomyosarcoma (LMS). METHODS:Intravenous gemcitabine was administered over 30 min at a dose of 1000 mg/m(2) on days 1, 8, 15, with cycles repeated every 28 day...

journal_title：Gynecologic oncology

authors： Look KY,Sandler A,Blessing JA,Lucci JA 3rd,Rose PG,Gynecologic Oncology Group (GOG) Study.

更新日期：2004-02-01 00:00:00

abstract：:Sclerosing stromal cell tumors of the ovary are an uncommon neoplasm that usually does not produce hormonal imbalances. Most patients showing a hormonal effect from this lesion have had menstrual cycle disturbances. Infertility and endometrial hyperplasia have also been described. One other reported case had masculini...

journal_title：Gynecologic oncology

authors： Cashell AW,Cohen ML

更新日期：1991-12-01 00:00:00

abstract：OBJECTIVES:The objective of this pilot study was to determine if frailty predicts surgical complications among elderly women undergoing gynecologic oncology procedures. METHODS:A cohort of gynecologic oncology patients age ≥ 65, undergoing surgery between March and December 2011 was identified. Frailty was evaluated u...

journal_title：Gynecologic oncology

authors： Courtney-Brooks M,Tellawi AR,Scalici J,Duska LR,Jazaeri AA,Modesitt SC,Cantrell LA

更新日期：2012-07-01 00:00:00

abstract：:The records of 125 patients with nonmucinous invasive ovarian adenocarcinoma who underwent cytoreductive surgery, cisplatin-based combination chemotherapy, and second-look laparotomy were analyzed to correlate pre-second-look serum CA-125 levels with the size of residual ovarian cancer. The majority of patients with n...

journal_title：Gynecologic oncology

authors： Patsner B,Orr JW Jr,Mann WJ Jr,Taylor PT,Partridge E,Allmen T

更新日期：1990-06-01 00:00:00

abstract：OBJECTIVES:Host genetic factors may play a role in human papillomavirus (HPV)-associated tumorigenesis, although the issue continues to be a focus of much debate. Biotransformation is critical in carcinogenic activity of numerous environmental carcinogens. It is therefore possible that polymorphisms of genes producing ...

journal_title：Gynecologic oncology

authors： Joseph T,Chacko P,Wesley R,Jayaprakash PG,James FV,Pillai MR

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVES:Epidermal Growth Factor Receptor (EGF-R) up-regulation in cervical cancer cells leads to an increase in cell proliferative Insulin-like Growth Factor II (IGF-II) and Vascular Endothelial Growth Factor (VEGF) and a decrease of the anti-proliferative IGF-binding protein-3 (IGF-BP3). The objectives for this stu...

journal_title：Gynecologic oncology

authors： Mathur RS,Mathur SP

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:This trial determined the efficacy and tolerability of sorafenib and weekly topotecan in patients with platinum-resistant ovarian cancer (OC) or primary peritoneal carcinomatosis (PPC). METHODS:Primary endpoints were maximum tolerated dose of sorafenib with weekly topotecan (phase I) and response rate (phase...

journal_title：Gynecologic oncology

authors： Ramasubbaiah R,Perkins SM,Schilder J,Whalen C,Johnson CS,Callahan M,Jones T,Sutton G,Matei D

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVES:The PI3K/AKT/mTOR pathway is frequently overactivated in endometrial cancer (EC). We assessed the efficacy of ABTL0812, a novel first-in-class molecule presenting a unique mechanism of action inhibiting this pathway. METHODS:We investigated the effects of ABTL0812 on proliferation, cell death and modulation...

journal_title：Gynecologic oncology

authors： Felip I,Moiola CP,Megino-Luque C,Lopez-Gil C,Cabrera S,Solé-Sánchez S,Muñoz-Guardiola P,Megias-Roda E,Pérez-Montoyo H,Alfon J,Yeste-Velasco M,Santacana M,Dolcet X,Reques A,Oaknin A,Rodríguez-Freixinos V,Lizcano JM,Domèn

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:To determine if SAHA, a histone deacetylase inhibitor, decreases ovarian cancer cell viability when combined with paclitaxel in vitro, and to explore molecular alterations of combined paclitaxel+SAHA treatment. METHODS:SKOV3 and Hey ovarian cancer cell lines were treated for 24 h with paclitaxel, then re-tr...

journal_title：Gynecologic oncology

authors： Dietrich CS 3rd,Greenberg VL,DeSimone CP,Modesitt SC,van Nagell JR,Craven R,Zimmer SG

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:A phase II trial was conducted to evaluate the anti-tumor activity and adverse effects of capecitabine in women with measurable platinum-sensitive ovarian cancer or platinum-sensitive primary peritoneal cancer and to explore the ability of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and th...

journal_title：Gynecologic oncology

authors： Garcia AA,Blessing JA,Lenz HJ,Darcy KM,Mannel RS,Miller DS,Husseinzadeh N,Gynecologic Oncology Group.

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:Sialylation involving tumor formation and invasive behavior goes along with altered sialyltransferase (ST) activity. A potent ST inhibitor, soyasaponin I (SsaI), was discovered to selectively inhibit the cellular alpha2,3-sialyltranserase activity. In this study, we further test the effects of SsaI on modifyi...

journal_title：Gynecologic oncology

authors： Hsu CC,Lin TW,Chang WW,Wu CY,Lo WH,Wang PH,Tsai YC

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Vulvar synovial cell sarcomas are rare, with only four previously published cases in the literature. Traditionally, the primary management for these tumors has been surgery alone. CASE:We report a case of a large vulvar synovial cell sarcoma in a 50-year-old woman treated with comprehensive combined multimo...

journal_title：Gynecologic oncology

authors： Holloway CL,Russell AH,Muto M,Albert M,Viswanathan AN

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Primary vaginal adenosarcomas are extremely rare, and typical adenosarcomas are of low malignancy. However, aggressive forms with sarcomatous overgrowth have been reported, those appear to have a poor prognosis. CASE:A 52-year-old woman who had undergone prior surgery for uterine leiomyoma and an ovarian cy...

journal_title：Gynecologic oncology

authors： Toyoshima M,Akahira J,Moriya T,Hayakawa S,Yaegashi N

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:The incidence of cervical dysplasia and carcinoma is known to be increased in HIV-infected women. In addition, there is a positive correlation between HIV viral load (VL), CD4+ count, and opportunistic infections, as well as the incidence of various malignancies. This study compares HIV VL and CD4+ count wit...

journal_title：Gynecologic oncology

authors： Davis AT,Chakraborty H,Flowers L,Mosunjac MB

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:Racial genetic admixture (RGA), a measure to account for ancestral genetic background that correlates with individual's racial classification, could provide insights on causation of racial disparity in endometrial cancer (EC). Our objective is to evaluate the association of RGA with EC outcomes. METHODS:EC pat...

journal_title：Gynecologic oncology

authors： Rocconi RP,Lankes HA,Brady WE,Goodfellow PJ,Ramirez NC,Alvarez RD,Creasman W,Fernández JR

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:This study aimed to validate the preoperative scoring system adopted in the Kanagawa Cancer Center (KCC) to stratify endometrial cancer patients for lymphadenectomy according to the risk of developing lymph node metastasis (LNM). METHODS:The records of 432 and 221 uterine cancer patients treated in the KCC a...

journal_title：Gynecologic oncology

authors： Imai K,Kato H,Katayama K,Nakanishi K,Kawano A,Iura A,Konnai K,Onose R,Hirahara F,Miyagi E

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To determine if tumor-free distance (TFD) from the uterine serosa predicts surgicopathologic factors and outcome in surgically staged endometrial cancer, and to compare TFD with the traditional estimate of depth of myometrial invasion (DOI). METHODS:Patients who underwent complete surgical staging for primar...

journal_title：Gynecologic oncology

authors： Schwab KV,O'Malley DM,Fowler JM,Copeland LJ,Cohn DE

更新日期：2009-01-01 00:00:00