Primary vaginal adenosarcoma with sarcomatous overgrowth.

Abstract:

BACKGROUND:Primary vaginal adenosarcomas are extremely rare, and typical adenosarcomas are of low malignancy. However, aggressive forms with sarcomatous overgrowth have been reported, those appear to have a poor prognosis. CASE:A 52-year-old woman who had undergone prior surgery for uterine leiomyoma and an ovarian cyst (total abdominal hysterectomy and left salpingo-oophorectomy) presented 10 years later with a rapidly enlarging tumor arising from the vaginal cuff. Repetitive biopsy samples revealed a mixture of benign epithelial gland and malignant stromal components with periglandular stromal hypercellularity and sarcomatous overgrowth. A histological diagnosis of mullerian adenocarcinoma was made. The patient died from recurrent disease 9 months after surgery. CONCLUSION:Regardless of primary focus, adenosarcoma with sarcomatous overgrowth is associated with postoperative recurrence and a fatal outcome.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Toyoshima M,Akahira J,Moriya T,Hayakawa S,Yaegashi N

doi

10.1016/j.ygyno.2004.08.004

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

759-61

issue

3

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(04)00617-1

journal_volume

95

pub_type

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