Is antibiotic resistance a problem? A practical guide for hospital clinicians.

Abstract:

:Antibiotic resistance is an important concern for patients, physicians, healthcare managers, and policymakers. Inappropriate antimicrobial prescribing fuels the evolution of resistance, while poor basic hygiene facilitates the spread of resistant microbes between patients and healthcare staff. The development of infection with a resistant pathogen may lead to poorer health and economic outcomes. The problem for the frontline clinician, however, is how to balance the responsibility of prudent prescribing with the risk of sub-optimally treating a patient who may be infected with a resistant pathogen. This article discusses how hospital physicians can use severity and risk factor assessment, and knowledge of local microbial epidemiology, to guide empiric antibiotic prescribing. Most patients hospitalised with a community acquired bacterial infection in the UK can still be managed with a traditional first line antibiotic(s). In contrast, regimens that account for resistance are often required in patients with hospital acquired infections, particularly if the patient is critically ill.

journal_name

Postgrad Med J

authors

Barlow G,Nathwani D

doi

10.1136/pgmj.2005.035113

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

680-92

issue

961

eissn

0032-5473

issn

1469-0756

pii

81/961/680

journal_volume

81

pub_type

杂志文章,评审
  • Acute lymphoblastic leukaemia presenting with arthritis in an adult patient.

    abstract::The earliest manifestations of leukaemia often include rheumatic signs and symptoms. Arthritis is a well recognised complication of leukaemia in children, but acute and chronic leukaemia may also cause arthritis in adults. Leukaemic arthritis may occur at any time during the course of leukaemia and may be the presenti...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.75.885.425

    authors: Usalan C,Ozarslan E,Zengin N,Büyükaýk Y,Güllü YH

    更新日期:1999-07-01 00:00:00

  • Republished review: Surgical management of aortic root disease in Marfan syndrome and other congenital disorders associated with aortic root aneurysms.

    abstract::Elective root replacement in Marfan syndrome has improved life expectancy in affected patients. Three forms of surgery are now available: total root replacement (TRR) with a valved conduit, valve sparing root replacement (VSRR) and personalised external aortic root support (PEARS) with a macroporous mesh sleeve. TRR c...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2013-305132rep

    authors: Treasure T,Takkenberg JJ,Pepper J

    更新日期:2016-02-01 00:00:00

  • Haemorrhage through the ampulla of Vater.

    abstract::A patient with chronic pancreatitis presented with a series of massive upper gastrointestinal haemorrhages due to bleeding into the pancreatic duct. This report emphasizes the value of intensive investigation before surgery, since it may be impossible to identify the site of bleeding at laparotomy. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.716.533

    authors: Ribbans WJ,Pounder RE,Lindsay I

    更新日期:1985-06-01 00:00:00

  • Hospital-acquired serum phosphate derangements and their associated in-hospital mortality.

    abstract:BACKGROUND:We aimed to report the incidence of hospital-acquired hypophosphataemia and hyperphosphataemia along with their associated in-hospital mortality. METHODS:We included 15 869 adult patients hospitalised at a tertiary medical referral centre from January 2009 to December 2013, who had normal serum phosphate le...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2020-138872

    authors: Thongprayoon C,Cheungpasitporn W,Chewcharat A,Petnak T,Mao MA,Srivali N,Bathini T,Vallabhajosyula S,Qureshi F,Kashani K

    更新日期:2020-10-21 00:00:00

  • Left ventricular function in ischaemic heart disease. A review.

    abstract::The clinical significance of the abnormalities seen at left ventriculography in ischaemic heart disease is discussed. Aneurysms may be recognized when left ventriculography is combined with coronary arteriography to show the characteristic obliteration of the supplying artery. Localized areas of abnormal contraction s...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.54.627.16

    authors: Khattri HN,Raphael MJ,Sharma B,Steiner RE,Goodwin JF

    更新日期:1978-01-01 00:00:00

  • Immunogenicity of a recombinant DNA hepatitis B vaccine in neonates.

    abstract::Infants of HBsAg-positive mothers (Group I) as well as those born to women without HBV markers (Group II) were vaccinated with a 10 micrograms dose of a recombinant DNA hepatitis B vaccine within 24 hours after birth according to a 0, 1, and 2 month schedule, with a booster dose planned 12 months later. Vaccination re...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Meheus A,Alisjahbana A,Vranckx R,Sukadi A,Usman A,Ngantung W,Sugita E,Safary A,André F,Reniers J

    更新日期:1987-01-01 00:00:00

  • Subacute myelopathy caused by spinal venous infarction.

    abstract::A 44 year old female presented with a subacute myelopathy in association with pelvic venous thrombosis. It is inferred from the temporal relationship of these events that the patient suffered a subacute spinal venous infarction. This is discussed along with the aetiology, anatomical distribution and management of the ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.63.742.669

    authors: Clarke CE,Cumming WJ

    更新日期:1987-08-01 00:00:00

  • Paradoxical vocal cord motion disorder: past, present and future.

    abstract::Paradoxical vocal cord motion disorder (PVCM), also called vocal cord dysfunction, is an important differential diagnosis for asthma. The disorder is often misdiagnosed as asthma leading to unnecessary drug use, very high medical utilisation and occasionally tracheal intubation or tracheostomy. Laryngoscopy is the gol...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2006.052522

    authors: Ibrahim WH,Gheriani HA,Almohamed AA,Raza T

    更新日期:2007-03-01 00:00:00

  • Comparative trials of cefaclor AF in uncomplicated cystitis and asymptomatic bacteriuria.

    abstract::Two different doses of cefaclor advanced formulation (AF), a new sustained-release formulation of cefaclor, were compared with the regular formulation of cefaclor for efficacy and safety in the treatment of uncomplicated cystitis and asymptomatic bacteriuria. A 7-day course of treatment was used, and the trials were d...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Hamilton-Miller JM,Iravani A,Brumfitt W,Byers KS,Dere WH

    更新日期:1992-01-01 00:00:00

  • Carotid sinus syndrome after carotid artery surgery.

    abstract::A 63 year old woman had been intensively treated for recurrent carcinoma of the neck. Following acute vascular surgery of the carotid artery, she developed the vasodilatory type of the carotid sinus syndrome. The presentation of this type of the syndrome was remarkable, since it is usually associated with primary or m...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.68.800.463

    authors: Dees A,Baatenburg de Jong RJ,Meeuwis CA,de Boer MF,de Leeuw PW

    更新日期:1992-06-01 00:00:00

  • Roth's spots: an unusual presentation of HIV.

    abstract::A 46 year old Nigerian man presented with a four week history of progressive bilateral visual loss. He had been unwell, with weight loss, fever, and night sweats for six months. Dilated fundoscopy revealed macular haemorrhages and diffuse Roth's spots. The patient was found to be severely anaemic and a bone marrow asp...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.79.928.108

    authors: Vose MJ,Charles SJ

    更新日期:2003-02-01 00:00:00

  • Possible functional regression of insulinoma with prolonged octreotide.

    abstract::A 75 year old woman was treated for over three years with the somatostatin analogue, octreotide for an insulinoma. She had presented in a hypoglycaemic coma. C-peptide and insulin concentrations were both raised and an area of increased vascularity within the pancreas was shown by angiography. No lesion was found at l...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.78.924.623

    authors: Craig CE,Gallen IW

    更新日期:2002-10-01 00:00:00

  • Ileo-caecal tuberculosis in immigrants.

    abstract::Four cases of ileo-caecal tuberculosis in Asian immigrants were seen in a 6-month period at The London Hospital. Although rare in Caucasians, this condition is an important cause of gastrointestinal symptoms in this ethnic group. Definitive diagnosis can frequently be made only by histological examination and culture ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.54.632.410

    authors: Croker J,Record CO,Wright JT

    更新日期:1978-06-01 00:00:00

  • Early-onset dementia: key issues using a relationship-centred care approach.

    abstract::People with early-onset dementia have a potential risk of being marginalised with respect to care and social support as a result of the blame and stigma associated with their condition, and because they have reduced access to treatment options and postdiagnostic care. The limited use of community services and the resu...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2020-138517

    authors: Nwadiugwu M

    更新日期:2020-09-03 00:00:00

  • Spontaneous mid-oesophageal rupture.

    abstract::The clinical presentation and management of spontaneous rupture of the middle third of the oesophagus is described in two patients. Early presentation and treatment in one case led to uncomplicated recovery. In the other patient late presentation and diagnosis resulted in delayed surgical intervention with an unsucces...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.54.634.559

    authors: Holt S,Millar JW,Heading RC,Charles RG

    更新日期:1978-08-01 00:00:00

  • Recurrent thrombosis and anticardiolipin antibodies associated with adenocarcinoma of the lung.

    abstract::A case of adenocarcinoma of the lung, in which high titre anticardiolipin antibodies were associated with recurrent venous thromboses resistant to all forms of therapy, is described. It is suggested that such an autoimmune response may be a contributory factor in the para-neoplastic development of vascular thromboses....

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.66.774.316

    authors: Shaukat MN,Hughes P

    更新日期:1990-04-01 00:00:00

  • Cerebral neoplastic angioendotheleosis complicated by hypercalcaemia.

    abstract::This is a case report of a 67 year old man who presented with a fluctuating level of consciousness and myoclonic jerks caused in part by hypercalcaemia. The diagnosis of cerebral neoplastic angioendotheleosis was only made later on brain biopsy and is the first report of the occurrence of hypercalcaemia in neoplastic ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.67.788.571

    authors: Wierzbicki AS,Gibbs JM,Lidov HG,Lolin Y,Thomas PK

    更新日期:1991-06-01 00:00:00

  • Acquired common variable hypogammaglobulinaemia and lymphoedema.

    abstract::Two patients with lymphoedema of the legs developed recurrent respiratory infections and were found to have panhypogammaglobulinaemia. The early recognition and treatment of this form of immunity deficiency in patients with lymphoedema is important in order to prevent recurrent infections which could cause pulmonary d...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.747.63

    authors: Lozewicz S,Morris G,Garbett N,Browse N,Slavin B,Cole P

    更新日期:1988-01-01 00:00:00

  • Toxic shock syndrome in Britain--epidemiology and microbiology.

    abstract::By 30 June 1984, only 99 confirmed and probable cases of toxic shock syndrome (TSS) had been reported in the British Isles. Sixty-three were related to menstruation in women aged 14 to 54 years who used tampons of various brands and absorbencies; 33 (52%) of these cases were in girls under 20. Five women died (8%) and...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: de Saxe MJ,Hawtin P,Wieneke AA

    更新日期:1985-01-01 00:00:00

  • Fatal tension pneumoperitoneum due to aerophagy.

    abstract::A case of fetal tension pneumoperitoneum following gastric perforation due to aerophagy is described. Comment is made on the probably pathogenesis. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.56.657.516

    authors: Hutchinson GH,Alderson DM,Turnberg LA

    更新日期:1980-07-01 00:00:00

  • Four years of experience of telemedicine for paediatric care in three Punjab hospitals, North India: achievements and lessons.

    abstract::Children in India constitute a very high risk group from mortality and morbidity due to lack of specialised healthcare. Remote care of paediatric patients by offsite specialists using telemedicine technology is a highly potential solution for coping up with the shortage of specialists in Indian subcontinent. We at a t...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2009.082735

    authors: Singh M,Das RR

    更新日期:2010-12-01 00:00:00

  • Gall-bladder polyps in Peutz-Jeghers syndrome.

    abstract::A case of Peutz-Jeghers syndrome with polyps in the gall bladder is presented. No previous description of this finding has been reported. The literature regarding known sites of polyposis in this condition is reviewed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.56.655.373

    authors: Foster DR,Foster DB

    更新日期:1980-05-01 00:00:00

  • Heatstroke and rhabdomyolysis presenting as fulminant hepatic failure.

    abstract::Heatstroke following vigorous exercise is reported in a young male. Severe hepatic and renal failure resulted but the patient completely recovered following treatment by active measures to reduce his core temperature. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.748.157

    authors: Fidler S,Fagan E,Williams R,Dewhurst I,Cory CE

    更新日期:1988-02-01 00:00:00

  • Quality of life and alteration in comorbidity following laparoscopic adjustable gastric banding.

    abstract:OBJECTIVES:Obesity is an increasing problem in the UK and bariatric surgery is likely to increase in volume in the future. While substantial weight loss is the primary outcome following bariatric surgery, the effect on obesity-related morbidity, mortality and quality of life (QOL) is equally important. This study repor...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2006.055558

    authors: Titi M,Jenkins JT,Modak P,Galloway DJ

    更新日期:2007-07-01 00:00:00

  • Intestinal obstruction secondary to a congenital pre-iliac hernia.

    abstract::A previously undescribed type of congenital abdominal wall hernia is described. Presentation was with the symptoms and signs of subacute large bowel obstruction. The diagnosis was suggested by barium enema and confirmed at laparotomy. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.760.112

    authors: Siriwardena AK

    更新日期:1989-02-01 00:00:00

  • Neurological complications of human immunodeficiency virus infection.

    abstract::The protean neurological manifestations of human immunodeficiency virus (HIV) infection are reviewed. Both the central nervous system and peripheral nervous system may be affected and many of the complications may occur in individuals with acquired immunodeficiency syndrome (AIDS)-related complex, or who are seroposit...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.64.749.180

    authors: Kennedy PG

    更新日期:1988-03-01 00:00:00

  • Antibiotic prescription for patients referred to a specialist breast clinic.

    abstract::Hospital referral is indicated as an emergency for breast infections not settling with oral antibiotics. Referrals to a breast clinic over a period of 6 months were assessed for prior antibiotic prescription. A total of 1078 patients were seen during this period. 91 (8%) patients had been prescribed antibiotics, 71% o...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2006.049296

    authors: Twine C,Gateley CA

    更新日期:2006-11-01 00:00:00

  • Cellular profile of bronchoalveolar lavage fluid in Turkish miners.

    abstract::Pneumoconiosis is still a health problem in Turkey and has a relatively high incidence. Retired underground miners were investigated to document alveolitis, and to observe the difference in the cellular profiles of bronchoalveolar lavage (BAL) fluid with or without pneumoconiosis. Twenty nine retired male miners and 1...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.79.935.527

    authors: Kayacan O,Beder S,Karnak D

    更新日期:2003-09-01 00:00:00

  • Microscopic polyarteritis: clinical features and treatment.

    abstract::The clinical features, treatment and survival of 36 patients with microscopic polyarteritis diagnosed between 1957-1988 have been reviewed. All had a focal segmental necrotizing glomerulonephritis on renal biopsy with evidence of a small vessel vasculitis. Most had a prodromal illness of less than 1 month. Severity of...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.766.515

    authors: Rodgers H,Guthrie JA,Brownjohn AM,Turney JH

    更新日期:1989-08-01 00:00:00

  • Diurnal rhythms and clinical events in coronary artery disease.

    abstract::Patients with coronary atherosclerosis present with angina, myocardial infarction and sudden death, most often caused by atherosclerotic stenosis complicated by spasm and/or occlusive thrombosis. All of these events have been shown to exhibit similar diurnal rhythms, with a peak incidence in the morning after waking a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Selwyn AP,Raby K,Vita JA,Ganz P,Yeung A

    更新日期:1991-01-01 00:00:00