Abstract:
:The effects of a 3-week computerised alertness training on chronic (>3 months) visuospatial hemineglect were investigated prospectively in seven patients by means of neuropsychological tests and functional magnetic resonance imaging (fMRI). Following the alertness training, the group showed improved alertness and a significant improvement in the performance of a neglect test battery over and above any improvement during a 3-week baseline phase. Improvements in the neglect tasks were accompanied by an increase of right hemisphere neural activity in frontal cortex, anterior cingulate cortex, precuneus, cuneus and angular gyrus. These areas have previously been associated with alertness and spatial attention. A similar pattern of increased neural activity was found for the left hemisphere. Four weeks after the end of the training, the patients' neglect test performance had mostly returned to baseline, while the increases in neural activity bilaterally in frontal areas, in the right anterior cingulate cortex, the right angular gyrus and the left temporoparietal cortex remained. The data show that a 3-week computerised alertness training can improve performance both in alertness and neglect tests and that these behavioural improvements are associated with reactivation in areas associated with alerting and visuospatial attention. The limited stability of these effects over time suggests that a 3-week alertness training alone does not result in long lasting improvements in every patient, but refining the treatment protocol may lead to a more stable amelioration of neglect symptoms.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Thimm M,Fink GR,Küst J,Karbe H,Sturm Wdoi
10.1016/j.neuropsychologia.2005.09.008subject
Has Abstractpub_date
2006-01-01 00:00:00pages
1230-46issue
7eissn
0028-3932issn
1873-3514pii
S0028-3932(05)00315-5journal_volume
44pub_type
杂志文章相关文献
NEUROPSYCHOLOGIA文献大全abstract::Episodic memory depends upon multiple dissociable retrieval processes. Here we investigated the degree to which the processes engaged during successful retrieval are dependent on the properties of the representations that underlie memory for an event. Specifically we examined whether the individual elements of an even...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2006.06.022
更新日期:2007-01-28 00:00:00
abstract::The right posterior superior temporal sulcus (pSTS) shows a strong response to voices, but the cognitive processes generating this response are unclear. One possibility is that this activity reflects basic voice processing. However, several fMRI and magnetoencephalography findings suggest instead that pSTS serves as a...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.03.008
更新日期:2017-10-01 00:00:00
abstract::The present essay reviews a series of functional magnetic resonance imaging (fMRI) studies conducted in parallel in humans and awake monkeys, concentrating on the intraparietal sulcus (IPS). MR responses to a range of visual stimuli indicate that the human IPS contains more functional regions along its anterior-poster...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2005.11.001
更新日期:2006-01-01 00:00:00
abstract::Traditionally, functional differences in the visual modality between the two hemispheres are investigated by tachistoscopic procedures. In these experiments, the stimuli reach the contralateral hemisphere first, and results are commonly interpreted on the basis of neuroanatomical access models. However, numerous studi...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(99)00129-3
更新日期:2000-01-01 00:00:00
abstract::The repetitive finger tapping of 24 right-handed subjects from dextral and sinistral families was evaluated. Subjects tapped with and without concurrent verbal tasks which included reciting a nursery rhyme, reading words (silent vs aloud) and solving anagrams (silent vs aloud). Overall, results indicated that the conc...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(83)90059-3
更新日期:1983-01-01 00:00:00
abstract::In two experiments, normal subjects named briefly presented pictures of objects that were shown either to the left or to the right of fixation. The net effects attributable to hemifield were negligible: naming RTs were 12 msec lower for pictures shown in the left visual field but error rates were slightly lower, by 0....
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(91)90102-e
更新日期:1991-01-01 00:00:00
abstract::Overweight or obesity can be accompanied by abnormalities in executive function and related neural markers. The aim of the present study was to investigate the behavioral and neural correlates of food-related decision-making in overweight and normal-weight adults. We used a delayed discounting task (DDT), which requir...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2019.107181
更新日期:2019-10-01 00:00:00
abstract::Monkeys' spontaneous behaviors in cancelling a variety of visual and somatosensory stimuli were measured before, and acutely after, unilateral periarcuate (N = 16) and inferior parietal (n = 14) cortical removals. Postoperative behavior was analyzed for both severity of change from the preoperative baseline, and for t...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(93)90078-e
更新日期:1993-01-01 00:00:00
abstract::Two underlying components of verbal fluency tasks have been identified as clustering (the ability to generate successive words within a sub-category) and switching (the ability to shift from one sub-category to another). Selective impairment of switching ability occurs in patients with frontostriatal pathology, whilst...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(01)00217-2
更新日期:2002-01-01 00:00:00
abstract::Dopaminergic medication in Parkinson's disease has been proposed to improve cognitive processing by modulating the severely depleted dorsal striatum, while impairing reward processing by modulating the relatively intact ventral striatum. However, there is no direct (neural) evidence for this hypothesis. Here we fill t...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2014.05.023
更新日期:2014-09-01 00:00:00
abstract::Diffusion Tensor Imaging (DTI) was used to investigate the relationship between white matter and reading abilities in reading impaired and non-reading impaired children. Seventeen children (7 non-reading impaired, 10 reading impaired) participated in this study. DTI was performed with 2mm isotropic resolution to cover...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2009.03.009
更新日期:2009-07-01 00:00:00
abstract::The variability of episodic memory decline and hippocampal atrophy observed with increasing age may partly be explained by genetic factors. KIBRA (kidney and brain expressed protein) and CLSTN2 (calsyntenin 2) are two candidate genes previously linked to episodic memory performance and volume of the hippocampus, a key...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2015.09.031
更新日期:2015-11-01 00:00:00
abstract::The effect of unilateral temporal- or frontal-lobe lesions on the capacity of short-term memory for a single pattern was explored; this measure has been designated pattern span. Pattern span was assessed under different delays and with and without distraction. Both the passage of time and presence of distraction decre...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(94)90046-9
更新日期:1994-08-01 00:00:00
abstract::Alzheimer's disease (AD) involves not only gray matter but also white matter pathology, as reflected by atrophy of the corpus callosum (CC). Since decreased CC size may indicate reduced functional interhemispheric connectivity, differences in callosal size may have cognitive consequences that may become specifically a...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2005.05.002
更新日期:2006-01-01 00:00:00
abstract::Previous research has suggested that bilinguals may exhibit cognitive advantages over those who are monolingual, although conflicting results have been reported. This advantage may be heightened in older adults, because of age-related cognitive decline. However, the effects of bilingualism on working memory performanc...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2020.107468
更新日期:2020-06-01 00:00:00
abstract::We use a unique environment of Whole Body Perceptual Deprivation (WBPD) to induce an altered state of consciousness (ASC) in our participants, and employ online EEG recording. We present individual EEG alpha profiles, and show how these data can be analyzed at the individual level. Our goal is to investigate to what d...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2019.01.018
更新日期:2019-03-04 00:00:00
abstract::Cerebral amyloid beta (Aβ) deposition occurs in a substantial fraction of cognitively normal (CN) older individuals. However, it has been difficult to reliably detect evidence of amyloid-related cognitive alterations in CN using standard neuropsychological measures. We sought to determine whether a highly demanding fa...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.06.006
更新日期:2011-07-01 00:00:00
abstract::Mimicry has been suggested to function as a "social glue", a key mechanism that helps to build social rapport. It leads to increased feeling of closeness toward the mimicker as well as greater liking, suggesting close bidirectional links with reward. In recent work using eye-gaze tracking, we have demonstrated that th...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.08.018
更新日期:2018-07-31 00:00:00
abstract::Epidemiological population studies highlight the presence of substantial individual variability in reading skill, with approximately 5-10% of individuals characterized as having specific reading disability (SRD). Despite reported substantial heritability, typical for a complex trait, the specifics of the connections b...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2018.07.015
更新日期:2019-07-01 00:00:00
abstract::The brain activity during a sentence reading task and a visual control task was examined with fMRI in 13 German dyslexic readers and 15 age-matched fluent readers (age: 14-16 years). These participants came from a longitudinal study and the dyslexic readers exhibited a persistent reading fluency deficit from early on....
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2006.03.010
更新日期:2006-01-01 00:00:00
abstract::Forty-three consecutively admitted Parkinsonian patients, of whom over a third had undergone stereotactic surgery about a decade previously, and a small control group were given a confrontation naming task. A number of comparisons were made, under the rubrics of success in naming, types of error and response latency, ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(86)90012-6
更新日期:1986-01-01 00:00:00
abstract::Pseudoneglect refers to a tendency of neurologically healthy individuals to produce leftward perceptual biases during spatial tasks, which is traditionally measured using line bisection tasks. This behavioral asymmetry is often explained as a consequence of right hemispheric dominance for visuospatial attention. The p...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2020.107634
更新日期:2020-11-01 00:00:00
abstract::Patients with homonymous hemianopia may report the completion of forms that overlap the vertical meridian of their field defects. While previous investigations of "hemianopic completion" have variously attributed to the disorder to inattention, residual vision or unstable fixation, we believe that our investigation ha...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2006.01.036
更新日期:2006-01-01 00:00:00
abstract::Infants are sensitive to structure and patterns within continuous streams of sensory input. This sensitivity relies on statistical learning, the ability to detect predictable regularities in spatial and temporal sequences. Recent evidence has shown that infants can detect statistical regularities in action sequences t...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.05.007
更新日期:2019-03-18 00:00:00
abstract::The Aprosodia Battery was developed to distinguish different patterns of affective-prosodic deficits in patients with left versus right brain damage by using affective utterances with incrementally reduced verbal-articulatory demands. It has also been used to assess affective-prosodic performance in various clinical g...
journal_title:Neuropsychologia
pub_type: 杂志文章,多中心研究
doi:10.1016/j.neuropsychologia.2010.12.024
更新日期:2011-04-01 00:00:00
abstract::This study investigated the cerebral correlates of the Trail Making Test (TMT), used commonly as a measure of frontal lobe function. Such work sheds additional light on the known shortcomings of the TMT as a localizing instrument, as indicated, for example, by studies of patients with focal brain lesions. Functional m...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2005.03.013
更新日期:2005-01-01 00:00:00
abstract::Severe left visual neglect has previously been shown to reduce when left hand movements in left hemispace were performed simultaneously to a series of cancellation tasks (Robertson and North, Neuropsychologia 30, 553-563, 1992). The present study demonstrates in two separate cases that this advantage associated with l...
journal_title:Neuropsychologia
pub_type: 评论,杂志文章
doi:10.1016/0028-3932(94)90064-7
更新日期:1994-01-01 00:00:00
abstract::Neglect patients are not aware of stimuli in the contralesional space. We aimed to simulate neglect-like behaviour in healthy participants, by asking them to orient their visuospatial attention in two conditions: non-hypnotic suggestion and post-hypnotic suggestion. Results showed that directing visuospatial attention...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.08.008
更新日期:2011-10-01 00:00:00
abstract::Recent animal studies have shown that stress can profoundly affect motor behaviour and worsen motor deficits associated with Parkinson's disease (PD) by acting on the dopaminergic system, possibly due to stress-associated emotional changes. However, systematic investigation of the influence of acute emotional stressor...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2018.03.006
更新日期:2018-04-01 00:00:00
abstract::Mutual adaptive timing (MAT), the capacity to adapt one's timing to the timing of a partner, is a form of interpersonal entrainment necessary to play music in ensemble. To this respect, two questions can be advanced. First, whether MAT can be seen also in non-musician populations. This might imply interesting theoreti...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2018.08.017
更新日期:2018-10-01 00:00:00