Abstract:
:The variability of episodic memory decline and hippocampal atrophy observed with increasing age may partly be explained by genetic factors. KIBRA (kidney and brain expressed protein) and CLSTN2 (calsyntenin 2) are two candidate genes previously linked to episodic memory performance and volume of the hippocampus, a key memory structure. However, whether polymorphisms in these two genes also influence age-related longitudinal memory decline and hippocampal atrophy is still unknown. Using data from two independent cohorts, the Sydney Memory and Ageing Study and the Older Australian Twins Study, we investigated whether the KIBRA and CLSTN2 genetic polymorphisms (rs17070145 and rs6439886) are associated with episodic memory performance and hippocampal volume in older adults (65-90 years at baseline). We were able to examine these polymorphisms in relation to memory and hippocampal volume using cross-sectional data and, more importantly, also using longitudinal data (2 years between testing occasions). Overall we did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in two cohorts of older adults.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Boraxbekk CJ,Ames D,Kochan NA,Lee T,Thalamuthu A,Wen W,Armstrong NJ,Kwok JB,Schofield PR,Reppermund S,Wright MJ,Trollor JN,Brodaty H,Sachdev P,Mather KAdoi
10.1016/j.neuropsychologia.2015.09.031subject
Has Abstractpub_date
2015-11-01 00:00:00pages
10-7eissn
0028-3932issn
1873-3514pii
S0028-3932(15)30174-3journal_volume
78pub_type
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