Greater striatal responses to medication in Parkinson׳s disease are associated with better task-switching but worse reward performance.

Abstract:

:Dopaminergic medication in Parkinson's disease has been proposed to improve cognitive processing by modulating the severely depleted dorsal striatum, while impairing reward processing by modulating the relatively intact ventral striatum. However, there is no direct (neural) evidence for this hypothesis. Here we fill this gap by scanning Parkinson's disease patients (n=15) ON and relatively OFF their dopaminergic medication using functional magnetic resonance imaging. During scanning, patients performed a task that enabled the simultaneous measurement of task-switching and reward-related processing. Brain-behavior correlations revealed that medication-related increases (ON-OFF) in switch-related BOLD signal (switch-repeat) in the dorsomedial striatum were associated, on an individual basis, with improvements in task-switching (i.e. a decreased switch cost). Conversely, medication-related increases (ON-OFF) in reward-related BOLD signal (high-low) in the ventromedial striatum were associated, on an individual basis, with impairments in performance in anticipation of reward (i.e. an increased reward cost). Linear regression analyses demonstrated that the positive relationship between medication-related changes in BOLD and the reward cost was unique to the ventromedial striatum, whereas the negative relationship between medication-related changes in BOLD and the switch cost was not unique to the dorsomedial striatum. These findings extend the dopamine overdose hypothesis, according to which dopamine-induced changes in dorsal and ventral striatal processing lead to cognitive improvement and impairment respectively.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Aarts E,Nusselein AA,Smittenaar P,Helmich RC,Bloem BR,Cools R

doi

10.1016/j.neuropsychologia.2014.05.023

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

390-7

eissn

0028-3932

issn

1873-3514

pii

S0028-3932(14)00171-7

journal_volume

62

pub_type

杂志文章
  • Modifying the brain activation of poor readers during sentence comprehension with extended remedial instruction: a longitudinal study of neuroplasticity.

    abstract::This study used fMRI to longitudinally assess the impact of intensive remedial instruction on cortical activation among 5th grade poor readers during a sentence comprehension task. The children were tested at three time points: prior to remediation, after 100 h of intensive instruction, and 1 year after the instructio...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2008.03.012

    authors: Meyler A,Keller TA,Cherkassky VL,Gabrieli JD,Just MA

    更新日期:2008-08-01 00:00:00

  • The role of inferior frontal cortex in belief-bias reasoning: an rTMS study.

    abstract::The belief-bias effect in syllogistic reasoning refers to the tendency for subjects to be erroneously biased when logical conclusions are incongruent with belief about the world. This study examined the role of inferior frontal cortex (IFC) in belief-bias reasoning using repetitive transcranial magnetic stimulation (r...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2010.03.021

    authors: Tsujii T,Masuda S,Akiyama T,Watanabe S

    更新日期:2010-06-01 00:00:00

  • Perceptual flexibility after frontal or temporal lobectomy.

    abstract::Using stimuli with ambiguous figure-ground relationships, Ricci and Blundo (1990, Neuropsychologia 28, 1163-1173) demonstrated that patients with frontal-lobe lesions are impaired at shifting perspective. No significant difference between right frontal and left frontal groups was found. To investigate this phenomenon ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(94)90159-7

    authors: Meenan JP,Miller LA

    更新日期:1994-09-01 00:00:00

  • Neural responses elicited to face motion and vocalization pairings.

    abstract::During social interactions our brains continuously integrate incoming auditory and visual input from the movements and vocalizations of others. Yet, the dynamics of the neural events elicited to these multisensory stimuli remain largely uncharacterized. Here we recorded audiovisual scalp event-related potentials (ERPs...

    journal_title:Neuropsychologia

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.neuropsychologia.2006.04.017

    authors: Puce A,Epling JA,Thompson JC,Carrick OK

    更新日期:2007-01-07 00:00:00

  • Lexical judgments after right- or left-hemisphere injury.

    abstract::Patients with unilateral left- or right-hemisphere lesions were asked to make similarity judgments to visually presented words on the basis of rhyme, meaning or visual similarity. The left-hemisphere-injured group was significantly impaired, relative to controls, for all types of lexical judgments, with the greatest i...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(86)90002-3

    authors: Chiarello C,Church KL

    更新日期:1986-01-01 00:00:00

  • Disruption of synaesthesia by posthypnotic suggestion: an ERP study.

    abstract::This study examined whether the behavioral and electrophysiological correlates of synaesthetic response conflict could be disrupted by posthypnotic suggestion. We recorded event-related brain potentials while a highly suggestible face-color synaesthete and matched controls viewed congruently and incongruently colored ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2010.07.004

    authors: Terhune DB,Cardeña E,Lindgren M

    更新日期:2010-09-01 00:00:00

  • Automatic and voluntary orienting of attention in patients with visual neglect: horizontal and vertical dimensions.

    abstract::The present study was aimed at testing internally and externally-controlled mechanisms of covert orienting in patients with visuo-spatial neglect. Internally-controlled orienting was tested by presenting central informative cues. Externally-controlled orienting was tested by presenting peripheral non-informative cues....

    journal_title:Neuropsychologia

    pub_type: 临床试验,杂志文章

    doi:10.1016/0028-3932(94)90102-3

    authors: Làdavas E,Carletti M,Gori G

    更新日期:1994-10-01 00:00:00

  • Electrophysiological correlates of detecting a visual target and detecting its absence: the role of feature dimensions.

    abstract::Electrophysiological measurements were taken from observers performing a visual search within a single feature dimension, and between multiple dimensions. The N2pc to selected singleton target stimuli (rightward tilted lines) was increased when targets varied between feature dimensions, compared to the N2pc to the sam...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2010.07.005

    authors: Akyürek EG,Dinkelbach A,Schubö A,Müller HJ

    更新日期:2010-09-01 00:00:00

  • Intermanual information transfer in patients with lesions in the trunk of the corpus callosum.

    abstract::Interhemispheric transfer of haptic information was examined in six partially callosotomized patients and three control subjects. Three different portions of the trunk were severed in different subjects. The most anterior 10 mm of the trunk, anterior to the foramen of Monro, was sectioned in one patient. Three other p...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(84)90024-1

    authors: Bentin S,Sahar A,Moscovitch M

    更新日期:1984-01-01 00:00:00

  • The dependence of span and delayed-response performance on prefrontal cortex.

    abstract::Theoretical and empirical research on the cognitive functions of the prefrontal cortex have established that this region mediates what have been called 'executive' processes that can influence working and long-term memory. Despite the accumulation of such empirical evidence, the dependence of purely mnemonic portions ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章,meta分析

    doi:10.1016/s0028-3932(99)00021-4

    authors: D'Esposito M,Postle BR

    更新日期:1999-10-01 00:00:00

  • Disentangling neglect and hemianopia.

    abstract::In this paper we report findings which question the diagnosis of a hemianopia in B.Q., a 66-year-old lady who shows unilateral spatial neglect following a lesion to the right parietal lobe. The presence of a hemianopia has been indicated following two independent assessments of B.Q.'s visual fields. We examined B.Q.'s...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(91)90065-g

    authors: Walker R,Findlay JM,Young AW,Welch J

    更新日期:1991-01-01 00:00:00

  • Isolated numerical skills in posterior cortical atrophy--an fMRI study.

    abstract::Posterior cortical atrophy (PCA) is characterized by bilateral parieto-occipito-temporal atrophy and hypometabolism. Neuropsychological impairments include complex visual disturbances, alexia, agraphia, finger agnosia, right-left disorientation and dyscalculia. A recent case study reported severe numerical deficits wi...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2006.02.007

    authors: Delazer M,Benke T,Trieb T,Schocke M,Ischebeck A

    更新日期:2006-01-01 00:00:00

  • The PCSK6 gene is associated with handedness, the autism spectrum, and magical ideation in a non-clinical population.

    abstract::Common polymorphisms in the gene PCSK6, whose protein product mediates the development of brain and body asymmetry through the NODAL pathway, have recently been associated with handedness in three studies, making it a key candidate gene for understanding the developmental and expression of human lateralization. We tes...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2016.02.020

    authors: Robinson KJ,Hurd PL,Read S,Crespi BJ

    更新日期:2016-04-01 00:00:00

  • Visual search deficits in Parkinson's disease are attenuated by bottom-up target salience and top-down information.

    abstract::Patients with Parkinson's disease (PD), a degenerative disorder primarily affecting the nigrostriatal dopamine system, exhibit deficits in selecting task-relevant stimuli in the presence of irrelevant stimuli, such as in visual search tasks. However, results from previous studies suggest that these deficits may vary a...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2006.01.037

    authors: Horowitz TS,Choi WY,Horvitz JC,Côté LJ,Mangels JA

    更新日期:2006-01-01 00:00:00

  • It does not look odd to me: perceptual impairments and eye movements in amnesic patients with medial temporal lobe damage.

    abstract::Studies of people with memory impairments have shown that a specific set of brain structures in the medial temporal lobe (MTL) is vital for memory function. However, whether these structures have a role outside of memory remains contentious. Recent studies of amnesic patients with damage to two structures within the M...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2012.11.003

    authors: Erez J,Lee AC,Barense MD

    更新日期:2013-01-01 00:00:00

  • Parkinson's disease patient's behaviour in a covered maze learning task.

    abstract::A computerized maze task was constructed that allowed only partial vision of the maze structure and produced measurements for separate analysis of cognitive processes described as impaired in Parkinson's disease. Eighteen patients suffering from mild Parkinson's disease and 18 individually matched normal controls were...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(90)90008-c

    authors: Wallesch CW,Karnath HO,Papagno C,Zimmermann P,Deuschl G,Lücking CH

    更新日期:1990-01-01 00:00:00

  • Neural basis of functional fixedness during creative idea generation: An EEG study.

    abstract::Decades of problem solving and creativity research have converged to show that the ability to generate new and useful ideas can be blocked or impeded by intuitive biases leading to mental fixations. The present study aimed at investigating the neural bases of the processes involved in overcoming fixation effects durin...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2018.03.009

    authors: Camarda A,Salvia É,Vidal J,Weil B,Poirel N,Houdé O,Borst G,Cassotti M

    更新日期:2018-09-01 00:00:00

  • Disconnection agraphia in a case of multiple sclerosis: the isolation of letter movement plans from language.

    abstract::We report the case of a left-handed man (MCR), who presented with a peripheral agraphia as an early sign of multiple sclerosis. His left-handed writing was neologistic, whilst oral spelling, typing and spelling with the right hand were intact. Structural MRI scanning revealed a lesion of the body of the corpus callosu...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2004.12.011

    authors: Varley R,Cowell PE,Gibson A,Romanowski CA

    更新日期:2005-01-01 00:00:00

  • Atypical recruitment of medial prefrontal cortex in autism spectrum disorders: an fMRI study of two executive function tasks.

    abstract::Recent studies have suggested an uneven profile of executive dysfunction in autism spectrum disorders (ASD). For example, some authors have reported deficits on newly developed tests of executive function sensitive to rostral prefrontal function, despite spared, or even superior, performance on other tests. We investi...

    journal_title:Neuropsychologia

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.neuropsychologia.2008.03.025

    authors: Gilbert SJ,Bird G,Brindley R,Frith CD,Burgess PW

    更新日期:2008-01-01 00:00:00

  • Emotion recognition in Huntington's disease and frontotemporal dementia.

    abstract::A well-documented feature of Huntington's disease (HD) is disproportionate impairment in the ability to recognise the emotional expression of disgust. However, this finding has been challenged by studies that report no differential disgust impairment and attribute apparent differences across emotions to task difficult...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2008.04.018

    authors: Snowden JS,Austin NA,Sembi S,Thompson JC,Craufurd D,Neary D

    更新日期:2008-09-01 00:00:00

  • Gender agreement violations modulate beta oscillatory dynamics during sentence comprehension: A comparison of second language learners and native speakers.

    abstract::For native speakers, many studies suggest a link between oscillatory neural activity in the beta frequency range and syntactic processing. For late second language (L2) learners on the other hand, the extent to which the neural architecture supporting syntactic processing is similar to or different from that of native...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2016.06.031

    authors: Lewis AG,Lemhӧfer K,Schoffelen JM,Schriefers H

    更新日期:2016-08-01 00:00:00

  • Lexical and syntactic representations in the brain: an fMRI investigation with multi-voxel pattern analyses.

    abstract::Work in theoretical linguistics and psycholinguistics suggests that human linguistic knowledge forms a continuum between individual lexical items and abstract syntactic representations, with most linguistic representations falling between the two extremes and taking the form of lexical items stored together with the s...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2011.09.014

    authors: Fedorenko E,Nieto-Castañon A,Kanwisher N

    更新日期:2012-03-01 00:00:00

  • Cognitive activation during PET: a case study of monozygotic twins discordant for closed head injury.

    abstract::Using positron emission tomography (PET), we studied physiological changes in a patient with frontal lobe damage resulting from closed head injury by assessing his regional cerebral blood flow (rCBF) pattern relative to that of his uninjured monozygotic (MZ) cotwin and against normal variability between cotwins in 10 ...

    journal_title:Neuropsychologia

    pub_type: 临床试验,杂志文章

    doi:10.1016/0028-3932(95)00147-6

    authors: Kirkby BS,Van Horn JD,Ostrem JL,Weinberger DR,Berman KF

    更新日期:1996-07-01 00:00:00

  • Exceptions to the male advantage on a spatial task: family handedness and college major as factors identifying women who excel.

    abstract::Two factors, family handedness and college major, were investigated in order to identify the characteristics of women likely to excel on a mental rotation task. It was found that those likely to have the necessary combination of genetic potential and spatial experiences were right-handed women with nonright-handed rel...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(89)90113-9

    authors: Casey MB,Brabeck MM

    更新日期:1989-01-01 00:00:00

  • Material-dependent and material-independent selection processes in the frontal and parietal lobes: an event-related fMRI investigation of response competition.

    abstract::The present study used the flanker task [Percept. Psychophys. 16 (1974) 143] to identify neural structures that support response selection processes, and to determine which of these structures respond differently depending on the type of stimulus material associated with the response. Participants performed two versio...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/s0028-3932(03)00040-x

    authors: Hazeltine E,Bunge SA,Scanlon MD,Gabrieli JD

    更新日期:2003-01-01 00:00:00

  • Individual alpha frequency modulates sleep-related emotional memory consolidation.

    abstract::Alpha-band oscillatory activity is involved in modulating memory and attention. However, few studies have investigated individual differences in oscillatory activity during the encoding of emotional memory, particularly in sleep paradigms where sleep is thought to play an active role in memory consolidation. The curre...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2020.107660

    authors: Cross ZR,Santamaria A,Corcoran AW,Chatburn A,Alday PM,Coussens S,Kohler MJ

    更新日期:2020-11-01 00:00:00

  • The role of motor contagion in the prediction of action.

    abstract::It has been proposed that actions are intrinsically linked to perception. The idea behind these theories is that observing, imagining or in any way representing an action excites the motor programs used to execute that same action. There is neurophysiological evidence that neurons in premotor cortex of monkeys respond...

    journal_title:Neuropsychologia

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuropsychologia.2004.11.012

    authors: Blakemore SJ,Frith C

    更新日期:2005-01-01 00:00:00

  • Recognition and naming of famous faces in Alzheimer's disease: a cognitive analysis.

    abstract::A Famous Faces Test designed to assess face recognition, spontaneous naming, verbal identification of un-named faces, and cued naming using semantic and phonetic cues was administered to 22 patients with dementia of Alzheimer type (DAT) and 25 matched controls. The DAT patients were significantly impaired in all test ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(93)90128-m

    authors: Hodges JR,Salmon DP,Butters N

    更新日期:1993-08-01 00:00:00

  • Processing of binaural spatial information in human auditory cortex: neuromagnetic responses to interaural timing and level differences.

    abstract::This study was designed to test two hypotheses about binaural hearing: (1) that binaural cues are primarily processed in the hemisphere contralateral to the perceived location of a sound; and (2) that the two main binaural cues, interaural timing differences and interaural level differences, are processed in separate ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2010.05.008

    authors: Johnson BW,Hautus MJ

    更新日期:2010-07-01 00:00:00

  • Ear differences in children at two years of age.

    abstract::Twenty-six children (13 boys and 13 girls) aged from 21 to 35.5 months were presented with a dichotic test of recognition of familiar words. There was no significant ear difference on average, however, a clear right-ear preference did emerge in children of right-handed parents. This contrasted with the tendency toward...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(85)90053-3

    authors: Lokker R,Morais J

    更新日期:1985-01-01 00:00:00