Abstract：
:Posterior cortical atrophy (PCA) is characterized by bilateral parieto-occipito-temporal atrophy and hypometabolism. Neuropsychological impairments include complex visual disturbances, alexia, agraphia, finger agnosia, right-left disorientation and dyscalculia. A recent case study reported severe numerical deficits with some selectively preserved numerical skills in a patient affected by PCA [Delazer, M., Karner, E., Zamarian, L., Donnemiller, E., & Benke, T. (2006). Number processing in posterior cortical atrophy--a neuropsycholgical case study. Neuropsychologia]. In a functional magnetic resonance imaging (fMRI) study brain activation patterns related to these selectively preserved numerical skills were analyzed. Recitation of multiplication tables and counting forward were contrasted to word recitation in a block design. Contrasts between experimental conditions and control condition yielded significant activation of inferior and medial temporal structures. Since numerical processing is generally associated with parietal activation, it was hypothesized that preserved brain structures would compensate for the functional deficits.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Delazer M,Benke T,Trieb T,Schocke M,Ischebeck Adoi
10.1016/j.neuropsychologia.2006.02.007subject
Has Abstractpub_date
2006-01-01 00:00:00pages
1909-13issue
10eissn
0028-3932issn
1873-3514pii
S0028-3932(06)00051-0journal_volume
44pub_type
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