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Role of vascular nitric oxide synthase in endotoxin shock of Propionibacterium acnes-sensitized rats.

Abstract：

:The sensitivity of animals to endotoxin differs significantly between species. Thus, factors that determine the susceptibility to endotoxin may play important roles in the pathogenesis of septic shock. In order to determine the mechanism responsible for susceptibility to endotoxin, the effect of lipopolysaccharide (LPS) on the circulatory status of Propionibacterium acnes (PA)-sensitized rats was studied. Following the intravenous administration of a low dose of LPS, the arterial blood pressure of PA-treated rats, but not of normal animals, progressively decreased; the PA-sensitized animals died of circulatory shock within 7 h of LPS administration. N omega-nitro-L-arginine (NA) reduced the depressor effect of LPS by an L-arginine-inhibitable mechanism. Administration of LPS markedly increased the level of the inducible type of nitric oxide (NO) synthase in various tissues, including the aorta, of PA-treated rats but not of control animals. LPS also increased plasma levels of nitrate plus nitrite and aortic levels of cGMP. Dexamethasone inhibited the de novo synthesis of NO synthase in the aorta and other tissues and reduced the depressor effect of LPS. These and other findings suggest that induction of nitric oxide synthase in resistant arteries might underlie the pathogenesis of LPS-induced hypotension in PA-sensitized animals and the mechanism responsible for the susceptibility to endotoxin.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Kida T,Kuroki T,Kobayashi K,Inoue M

doi

10.1006/abbi.1994.1291

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

135-41

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(84)71291-4

journal_volume

312

pub_type

杂志文章

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