Stimulation of alveolar macrophages by BCG vaccine enhances the process of lung fibrosis induced by bleomycin.

Abstract:

:It was found that the BCG vaccine injected subcutaneously to the rats enhances the process of lung fibrosis induced by bleomycin. Pretreatment of rats with this vaccine results in accumulation of activated macrophages in lung interstitium and in the bronchoalveolar spaces. It may be suggested that the activated macrophages release various cytokines which may stimulate the proliferation of fibroblasts and biosynthesis of extracellular matrix components.

authors

Chyczewska E,Chyczewski L,Bańkowski E,Sułkowski S,Nikliński J

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

113-6

issue

3

eissn

0239-8508

issn

1897-5631

journal_volume

31

pub_type

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