Leptin concentrations in patients with polycystic ovary syndrome before and after met-formin treatment depending on insulin resistance, body mass index and androgen con-centrations--introductory report.

Abstract:

:Polycystic ovary syndrome (PCOS) is an endocrinological and metabolic disorder which may concern about 3-8% of women. Some PCOS women have the increased leptin concentration in blood serum. Leptin concentration is higher in patients with high body mass index (BMI) and impaired tissue sensitivity to insulin. The aim of this study was to determine leptin concentrations in PCOS patients before and after metformin treatment depending on BMI, insulin resistance calculated on the basis of the Homeostasis Model Assessment (HOMA) index, as well as concentrations of androgens: testosterone and androstendion. Such values as BMI, insulin resistance according to the HOMA index, and concentrations of androstendion, testosterone and leptin were determined in 35 patients with PCOS before and after 3-month metformin treatment administered in daily doses of 2 x 850 mg. Increased leptin levels before the therapy were observed in 91.3% (21 out of 23) of obese patients, in 75% (9 out of 12) non-obese patients, in 100% (8 patients) insulin resistance women, in 81.5% (22 out of 27) insulin sensitive patients, in 94.7% (18 out of 19) women with elevated androstendion concentration and in 75% (12 out of 16) with normal androstendion concentration, in 93.7% (15 out of 16) patients with increased testosterone concentration and in 78.9% (15 out of 19) patients with testosterone concentrations within the normal range. After treatment statistically significant decrease in leptin concentration was obtained in the patients with BMI

authors

Marciniak A,Nawrocka-Rutkowska J,Brodowska A,Sienkiewicz R,Szydłowska I,Starczewski A

doi

10.2478/v10042-009-0032-0

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

323-8

issue

2

eissn

0239-8508

issn

1897-5631

pii

C2643068W732Q353

journal_volume

47

pub_type

临床试验,杂志文章
  • Sequential translocation of tyrosine kinases Lyn and Syk to the activated Fcgamma receptors during phagocytosis.

    abstract::Tyrosine phosphorylation of numerous proteins is one of the earliest events detectable during Fcgamma receptor-mediated phagocytosis. We demonstrate that IgG-coated particles associated with the surface of macrophages are enriched with numerous tyrosine-phosphorylated proteins. During particle internalization the prot...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Strzelecka-Kiliszek A,Sobota A

    更新日期:2002-01-01 00:00:00

  • Quercetin suppresses heat shock-induced nuclear translocation of Hsp72.

    abstract::The effect of quercetin and heat shock on the Hsp72 level and distribution in HeLa cells was studied by Western blotting, indirect immunofluorescence and immunogold electron microscopy. In control cells and after quercetin treatment, Hsp72 was located both in the cytoplasm and in the nucleus in comparable amounts. Aft...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Jakubowicz-Gil J,Pawlikowska-Pawlega B,Piersiak T,Pawelec J,Gawron A

    更新日期:2005-01-01 00:00:00

  • The protective impact of Trans-Cinnamaldehyde (TCA) against the IL-1b induced inflammation in in vitro osteoarthritis model by regulating PI3K/AKT pathways.

    abstract:INTRODUCTION:Osteoarthritis (OA) is a severe joint degeneration disease in elderly people described by the advanced degradation of articular cartilage, which ultimately leads to chronic pain. Trans-cinnamaldehyde (TCA) exerted its anti-inflammatory function in numerous disease syndromes; however, its role in the pathog...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/FHC.a2020.0025

    authors: Wu JR,Zhong WJ,Chen ZD,Zhu BQ,Jiang YY,Wierzbicki PM

    更新日期:2020-01-01 00:00:00

  • CD40L and IL-4 stimulation of acute lymphoblastic leukemia cells results in upregulation of mRNA level of FLICE--an important component of apoptosis.

    abstract::The use of cancer vaccines based on dendritic cells (DC) presenting tumor antigens can be a promising tool in the treatment of leukemia. The functional characteristics of leukemia derived DC is still to be elucidated. CD40 promotes survival, proliferation and differentiation of normal B cells. CD40 triggering was used...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: łuczyński W,Kowalczuk O,Iłendo E,Stasiak-Barmuta A,Krawczuk-Rybak M,Malinowska I,Kołtan A,Szczepalński T,Olejnik I,Jaworowski R,Chyczewski L,Matysiak M,Wysocki M,Sońta-Jakimczyk D,Wieczorek M

    更新日期:2007-01-01 00:00:00

  • Bone as a source of organism vitality and regeneration.

    abstract::The most important features that determine the vital role of bone include: a) a continuous supply of calcium, which is indispensible for every cell of the entire organism at all times, and b) the delivery of circulating blood cells and some adult stem cells to keep the body vigorous, ready for self-reparation, and con...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章,评审

    doi:10.5603/fhc.2011.0079

    authors: Mackiewicz Z,Niklińska WE,Kowalewska J,Chyczewski L

    更新日期:2011-01-01 00:00:00

  • Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus.

    abstract::CD59 is one of the key molecules involved in cell protection against autologus complement. The fact that complement regulatory proteins are able to prevent hyperacute rejection of organs in pig to primate model, raises the question of possible complement regulatory protein (CRP) involvement in the maturation of immuno...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Sladowski D,Wasiutyński A,Wilczyński G,Grabska-Liberek I,Coecke S,Kinsner A,Kochanowska I

    更新日期:2006-01-01 00:00:00

  • STAT3, HIF-1alpha, EPO and EPOR - signaling proteins in human primary ductal breast cancers.

    abstract::STAT3 upregulates expression of HIF-1 induced EPO. Receptor EPOR was reported to activate STAT3. Our study was aimed at demonstration of tissue immunoreactivities of those proteins and determination of their relationships in reference to clinicopathological variables of breast cancers. We detected STAT3, HIF-1alpha, E...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Wincewicz A,Sulkowska M,Koda M,Leśniewicz T,Kanczuga-Koda L,Sulkowski S

    更新日期:2007-01-01 00:00:00

  • Contribution of stem cells to skeletal muscle regeneration.

    abstract::Stem cells for skeletal muscle originate from dermomyotome of the embryo. The early marker of these cells is expression of both transcription factors Pax3 and Pax7 (Pax3+/Pax7+ cells). The skeletal muscles in the adult organism have a remarkable ability to regenerate. Skeletal muscle damage induces degenerative phase,...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章,评审

    doi:

    authors: Kawiak J,Brzóska E,Grabowska I,Hoser G,Stremińska W,Wasilewska D,Machaj EK,Pojda Z,Moraczewski J

    更新日期:2006-01-01 00:00:00

  • Immunohistochemical visualization of pro-inflammatory cytokines and enzymes in ovarian tumors.

    abstract::Epithelial ovarian cancer represents one of the most deadly gynaecological neoplasms in developed countries and is a highly heterogeneous disease. Epidemiological studies show that anti-inflammatory drugs reduce the incidence and mortality of several types of cancer, indicating the potential role of pro-inflammatory f...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/FHC.2014.0015

    authors: Plewka D,Kowalczyk AE,Jakubiec-Bartnik B,Morek M,Bogunia E,Kmiec A,Wierzbicki PM,Plewka A

    更新日期:2014-01-01 00:00:00

  • Immunohistochemical localization of androgen receptor in rat oocytes.

    abstract::Immunohistochemical localization of androgen receptor (AR) was investigated in the rat oocytes during their development in the primary, secondary and antral follicles. The group of experimental Wistar rats included prepubertal female rats, killed at 30 days of age, and mature female rats killed at estrus or metestrus....

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Szołtys M,Słomczyńska M,Tabarowski Z

    更新日期:2003-01-01 00:00:00

  • Morphological and molecular aspects of cancerogenesis in the lung.

    abstract::Morphology and some molecular aspects of hyperplastic (bronchial basal cell hyperplasia and alveolar cell hyperplasia), metaplastic (squamous metaplasia), preneoplastic and early neoplastic (dysplasia in squamous metaplasia, cancer in situ and atypical alveolar cell hyperplasia) changes were studied in 180 lungs resec...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Chyczewski L,Chyczewska E,Nikliński J,Niklińska W,Sulkowska M,Naumnik W,Kovalchuk O

    更新日期:2001-01-01 00:00:00

  • Activity of delta(5)3beta-hydroxysteroid dehydrogenase and steroid hormones content in early preimplantation horse embryos.

    abstract::The activity of delta (5)3 beta-hydroxysteroid dehydrogenase was examined histochemically in 6 to 10 days aged horse blastocysts. A positive reaction was noted in the blastomeres of all embryos incubated in medium with substrate. Measurable amounts of progesterone, androgens and estrogens were found in blastocysts on ...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Paulo E,Tischner M

    更新日期:1985-01-01 00:00:00

  • Cytochemical studies on the antheridial mucilage and changes in its concentration and amount during the spermatogenesis in Chara vulgaris L.

    abstract::The internal space of the antheridium in Chara vulgaris L. is filled with the PAS-positive mucilage which is of pectic nature. Morphometric and cytophotometric measurements on the semithin sections indicate that the concentration and amount of PAS-positive polysaccharides: 1) increase during the time of antheridial gr...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Gosek A,Kwiatkowska M

    更新日期:1991-01-01 00:00:00

  • Phenotype of dendritic cells generated in the presence of non-small cell lung cancer antigens - preliminary report.

    abstract::Therapeutic outcomes of definitively treated non-small-cell lung cancer (NSCLC) are unacceptably poor. It has been proposed that the manipulation of dendritic cells (DCs) as a "natural" vaccine adjuvant may prove to be a particularly effective way to stimulate antitumor immunity. Presently, there is no standardized me...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.2478/v10042-008-0078-4

    authors: Jankowska O,Krawczyk P,Wojas-Krawczyk K,Sagan D,Milanowski J,Roliński J

    更新日期:2008-01-01 00:00:00

  • Transformation of a human mixed GH-PRL adenoma cell population in response to long-term bromocriptine treatment.

    abstract::A child was operated 3 times because of a recurrent growth hormone- and prolactin-producing pituitary adenoma. Between the operations she was treated for five years with bromocriptine. The characteristics of the tumour cell population collected after the last operation was now examined by electron microscopy, immunocy...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Bácsy E,Fazekas I,Slowik F,Pásztor E,Czirják S

    更新日期:1997-01-01 00:00:00

  • Human cathepsin D.

    abstract::A literature survey was performed of human cathepsin D gene, cathepsin D biosynthesis, posttranslatory modifications, transport within the cell, substrate specificity and catalytic effect. Methods used to determine the activity and level of this proteinase as well as its role in the biochemistry and pathobiochemistry ...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章,评审

    doi:10.2478/v10042-008-0003-x

    authors: Minarowska A,Gacko M,Karwowska A,Minarowski Ł

    更新日期:2008-01-01 00:00:00

  • Differential expression of chemokine receptor CXCR4 in Th1 and Th2 subtypes of CD4+ lymphocytes.

    abstract::Different cytokine profiles allow to divide the CD4+ lymphocytes into Th1, Th2 and Th0 subtypes. It has been observed that the Th2 cells are more efficient supporters for HIV-1 replication than the Th1 cells. The Th1 and the Th2 cells were isolated from peripheral blood lymphocytes of HIV-1 seronegative individuals an...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Jagodziński PP,Trzeciak WH

    更新日期:2000-01-01 00:00:00

  • Ghrelin and obestatin in thyroid gland - immunohistochemical expression in nodular goiter, papillary and medullary cancer.

    abstract:INTRODUCTION:Previous studies analyzing ghrelin and obestatin expression in thyroid gland tissue are not unanimous and are mostly related to ghrelin. The role of ghrelin and obestatin in the thyroid gland appears very interesting due to their probable involvement in cell proliferation. Furthermore, since the thyroid gl...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/FHC.a2015.0004

    authors: Gurgul E,Kasprzak A,Blaszczyk A,Biczysko M,Surdyk-Zasada J,Seraszek-Jaros A,Ruchala M

    更新日期:2015-01-01 00:00:00

  • Localization of a proteasomal antigen in human spermatozoa: immunohistochemical electron microscopic study.

    abstract::The ultrastructural localization of a proteasomal antigen in human spermatozoa was studied by means of immunolabeling with the MPC21 monoclonal antibody and secondary gold labeled antibody with 1.4 nm gold particles in combination with silver enhancement reaction using pre-embedding technique. The labeling was found i...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Biały LP,Ziemba HT,Marianowski P,Fracki S,Bury M,Wójcik C

    更新日期:2001-01-01 00:00:00

  • Immunoexpression of P16INK4a, Rb and TP53 proteins in bronchiolar columnar cell dysplasia (BCCD) in lungs resected due to primary non-small cell lung cancer.

    abstract::Lung cancer is the leading cause of death worldwide. High mortality comes out mainly of the fact that majority of the cases are diagnosed in advanced stadium. An expanded diagnostics of precancerous conditions would certainly contribute to lowering the mortality rate. Many of the molecular changes accompanying the mul...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.2478/v10042-008-0013-8

    authors: Pankiewicz W,Sulewska A,Niklinska W,Naumnik W,Laudanski J,Niklinski J,Chyczewski L

    更新日期:2008-01-01 00:00:00

  • Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos.

    abstract::Fertilization involves a series of cellular interactions culminating in the fusion of gamete membranes, creating a zygote and then an embryo. During the process of human fertilization in vivo or in conventional in vitro fertilization (IVF), sperm must be capable of undergoing the acrosome reaction, binding to the zona...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Depa-Martynów M,Kempisty B,Lianeri M,Jagodziński PP,Jedrzejczak P

    更新日期:2007-01-01 00:00:00

  • The effect of acute heat exposure on rat pituitary corticotroph activation: the role of vasopressin.

    abstract::The increased ambient temperature affects the function of hypothalamic-pituitary-adrenal (HPA) axis. Since the correlation among vasopressin (VP), adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses to various stressors have been long recognized, the aim of this study was to reveal the aforementione...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.2478/v10042-010-0071-6

    authors: Jasnic N,Korac A,Velickovic K,Golic I,Djordjevic J,Djurasevic S,Djordjevic I,Vujovic P,Cvijic G

    更新日期:2010-12-01 00:00:00

  • Circulating tumor cells in different stages of colorectal cancer.

    abstract:INTRODUCTION:Liquid biopsies are noninvasive tests using blood or body fluids to detect circulating tumor cells (CTCs) or the products of tumor cells, such as fragments of nucleic acids or proteins that are shed into biological fluids from primary tumor or its metastates. The analysis of published clinical studies prov...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/FHC.a2017.0005

    authors: Eliasova P,Pinkas M,Kolostova K,Gurlich R,Bobek V

    更新日期:2017-01-01 00:00:00

  • S-100 protein immunoreactivity in mammalian testis and epididymis.

    abstract::The present study deals with immunohistochemical localization of S-100 protein in mouse, bank vole and pine vole testis and epididymis. S-100 protein immunoreactivity was observed in the endothelia of capillaries and lymphatic sinusoids of pine vole testis. A reaction to S-100 protein of the same intensity as that not...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Czykier E,Sawicki B,Zabel M

    更新日期:2000-01-01 00:00:00

  • Predictive value of ERCC1 single-nucleotide polymorphism in patients receiving platinum-based chemotherapy for locally-advanced and advanced non-small cell lung cancer--a pilot study.

    abstract::Platinum-based chemotherapy is the main type of I-line treatment of advanced and non-operative NSCLC patients without EGFR gene mutation. The excision repair cross-complementation group 1 (ERCC1) is an enzyme that executes the incision of the damaged DNA strand and removes platinum-induced DNA adducts. We investigated...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.2478/18700

    authors: Krawczyk P,Wojas-Krawczyk K,Mlak R,Kucharczyk T,Biernacka B,Milanowski J

    更新日期:2012-04-24 00:00:00

  • Proliferating cell nuclear antigen (PCNA) expression in pituitary adenomas: relationship to the endocrine phenotype of adenoma.

    abstract::The expression of proliferating cell nuclear antigen (PCNA) correlates to cell proliferation and for this reason it is commonly considered as one of proliferation markers. Since proliferation rate is an important factor determining the tumor aggressiveness, the evaluation of PCNA index (the percentage of PCNA-immunopo...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:

    authors: Pawlikowski M,Gruszka A,Kurnatowska I,Winczyk K,Kunert-Radek J,Radek A

    更新日期:2006-01-01 00:00:00

  • Microtubule heterogeneity of Ornithogalum umbellatum ovary epidermal cells: non-stable cortical microtubules and stable lipotubuloid microtubules.

    abstract::Lipotubuloids, structures containing lipid bodies and microtubules, are described in ovary epidermal cells of Ornithogalum umbellatum. Microtubules of lipotubuloids can be fixed in electron microscope fixative containing only buffered OsO(4) or in glutaraldehyde with OsO(4) post-fixation, or in a mixture of OsO(4) and...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/fhc.2011.0040

    authors: Kwiatkowska M,Stępiński D,Polit JT,Popłońska K,Wojtczak A

    更新日期:2011-01-01 00:00:00

  • Age-associated functional morphology of thyroid and its impact on the expression of vimentin, cytokeratins and VEGF. The role of nigella in refinement.

    abstract:INTRODUCTION:Aging causes morphological and functional changes in the thyroid gland. Free radicals play a key role in the pathology of normal aging. Vimentin and cytokeratin are cytoskeletal intermediate filaments that are often used as indirect indices of tissue injury. The aim of the study was to clarify the age-rela...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/FHC.a2018.0015

    authors: Zaki SM,Mohamed EA,Abdel Fattah S,Abdullah H,Kaszubowska L

    更新日期:2018-01-01 00:00:00

  • Organization of the innervation of the oesophagus and stomach in chinchilla (Chinchilla laniger, Molina).

    abstract::Using the histochemical and histological techniques the morphology and topography of the autonomic plexuses of the oesophagus and stomach in chinchilla (Chinchilla laniger) was investigated. AChE-positive and adrenergic structures in the myenteric and submucosal plexus were observed. According to the results the choli...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.5603/FHC.2013.0018

    authors: Nowak E

    更新日期:2013-01-01 00:00:00

  • Inducible nitric oxide synthase immunoreactivity in healthy rat pancreas.

    abstract::Nitric oxide (NO) is produced by NO synthase (NOS) isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible NOS (iNOS). It is believed that, while nNOS and eNOS are effective in regulation of normal physiological processes, iNOS is expressed at an increasing rate especially in inflammatory process. The aim ...

    journal_title:Folia histochemica et cytobiologica

    pub_type: 杂志文章

    doi:10.2478/v10042-008-0032-5

    authors: Keklikoglu N

    更新日期:2008-01-01 00:00:00