Abstract:
:Ischemia/reperfusion (I/R) injury is a multifactorial process that affects liver function after transplantation and resectional surgery. Alterations in hepatic microcirculation and decreased hepatic flow can cause local hypoxia and consequently liver damage, which is worsened by reperfusion. The aim of this study was to evaluate if treatment with L-arginine improved hepatic function in rats with I/R injury. Animals were treated with L-arginine, ischemized for 30 min, and reperfused for 3 h. Plasmatic levels of GOT, GPT, lipid hydroperoxides (LOOH), and total thiol groups (RSH) were evaluated. In addition, we analyzed hepatic LOOH and RSH levels, DNA fragmentation, heme oxygenase 1 (HO-1) expression, and histological modifications. Our results demonstrate a significant improvement in hepatic function of I/R rats compared to the control group. Treatment with L-arginine increased the expression of HO-1. These data suggest that L-arginine could be useful in preventing oxidative damage during hepatic surgery.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Lanteri R,Acquaviva R,Di Giacomo C,Caltabiano R,Li Destri G,Vanella L,Santangelo M,Lanzafame S,Di Cataldo Adoi
10.1002/micr.20206subject
Has Abstractpub_date
2006-01-01 00:00:00pages
25-32issue
1eissn
0738-1085issn
1098-2752journal_volume
26pub_type
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