Abstract:
:Bile reflux may play a key role for esophageal carcinogenesis in reflux disease. In search for bile-specific effects, the animal model of esophageal cancer was applied in a mutagenesis assay. Big Blue transgenic mice were operated with microsurgical techniques. Seven had total gastrectomy with esophagojejunostomy creating esophageal reflux of bile and five had a sham operation. After 24 weeks, the mutation frequency (MF) was measured through standard Big Blue mutagenesis assay in the esophageal mucosa and the duodenum as control. Esophageal reflux resulted in esophagitis in the distal esophagus. The MF in esophageal mucosa was 1.6 times higher in animals with reflux than in sham-operated animals; it was identical in the duodenum. In conclusion, the mutagenic potential of bile reflux has been confirmed. However, mechanisms of carcinogenesis in the esophageal cancer model other than chronic inflammation could not be identified because of the only moderately increased MF.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Fein M,Peters JH,DeMeester TRdoi
10.1002/micr.20424subject
Has Abstractpub_date
2007-01-01 00:00:00pages
647-50issue
8eissn
0738-1085issn
1098-2752journal_volume
27pub_type
杂志文章相关文献
MICROSURGERY文献大全abstract::The authors present a new and efficient treatment for reconstruction of bilateral defective thumbs by different configured toe-tissues transplantations in a single stage, including bilateral second-toe transfer in 2 cases, bilateral hallux wrap-around flap transfer in 1 case, bilateral modified hallux wrap-around flap...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.10213
更新日期:2003-01-01 00:00:00
abstract::This study was designed to investigate regeneration of reinnervated, free transplanted muscles. We used a rat model, consisting of eight rats per group, in which the latissimus dorsi muscle was transplanted orthotopically and then harvested and evaluated after 2 and 12 weeks. Age-matched control animals were used to o...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920161205
更新日期:1995-01-01 00:00:00
abstract::There is a lack of agreement regarding the potential for peripheral nerve cells with short axons to regenerate and innervate the terminal end organs of nerve cells with long axons. We designed a study to evaluate experimentally the possibility of neurons to reconstitute much longer axonal segments. Twenty Wistar rats ...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920110203
更新日期:1990-01-01 00:00:00
abstract::End-to-side neurorrhaphy, a possible strategy for treating nerve lesions without useable proximal nerve stumps, has been experimentally and clinically investigated. In end-to-side neurorrhaphy, three main elements should be considered: 1) the induction of axonal collateral sprouting in the donor nerve; 2) the ability ...
journal_title:Microsurgery
pub_type: 杂志文章,评审
doi:10.1002/micr.21736
更新日期:2002-01-01 00:00:00
abstract::This is an experimental study comparing the suturing time and patency rate of a spiral interrupted suturing technique to those of conventional interrupted and continuous suturing technique in end-to-end as well as end-to-side anastomosis. The spiral interrupted suturing technique requires less time for either end-to-e...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920070205
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:Reconstruction of abdominal wall defects with enterocutaneous fistulas (ECF) remains challenging. The purpose of this report is to describe a single-stage approach using combined microscopic enterolysis, pedicle seromuscular bowel flaps, mesh, fasciocutaneous, and myocutaneous flaps. METHODS:Between 1990 ...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.30374
更新日期:2020-01-01 00:00:00
abstract::The authors report on a series of experiments designed to produce a skeletal muscle contraction functional for dynamic myoplasties. Conventional stimulation techniques recruit all or most of the muscle fibers simultaneously and with maximal strength. This approach has limitations in free dynamic muscle flap transfers ...
journal_title:Microsurgery
pub_type: 杂志文章,评审
doi:10.1002/micr.1052
更新日期:2001-01-01 00:00:00
abstract::Perivascular sympathectomy, which has been used for vasospastic disorders of the hands, was examined in experimental models. Perivascular sympathectomy was performed on the central ear vessels and forepaw metacarpal vessels of the rabbit and on the common digital vessels in the monkey. The effects on adrenergic nerves...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920150113
更新日期:1994-01-01 00:00:00
abstract::Ring avulsion can lead to soft tissue compromise resulting in eventual digit failure or restriction of motion. The authors present use of the venous flow through flap for simultaneous soft tissue and digital vessel reconstruction in severe ring avulsion injury. A retrospective review of ring avulsion injuries treated ...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20527
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Persistent genital arousal disorder (PGAD) is a woman's perception that she is in a state of sexual arousal, without the ability of arousal to be satisfied by orgasm. It is the hypothesis of this study that PGAD results from a minimal degree of nerve compression of the dorsal branch of the pudendal nerve. If...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.30464
更新日期:2020-02-01 00:00:00
abstract::There is evidence that nerve flaps are superior to nerve grafts for bridging long nerve defects. Moreover, arterialized neurovenous flaps (ANVFs) have multiple potential advantages over traditional nerve flaps in this context. This paper describes a case of reconstruction of a long defect of the ulnar artery and nerve...
journal_title:Microsurgery
pub_type: 杂志文章,评审
doi:10.1002/micr.30265
更新日期:2018-02-01 00:00:00
abstract::It is known that a vein graft provides a good microenvironment for axon regeneration in motor peripheral nerves, but the use of artery graft for regeneration of sensory nerves is controversial. We sectioned the saphenous nerve and repaired it by using heterologous inside-out and standard artery graft techniques in rat...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1017
更新日期:2001-01-01 00:00:00
abstract::Based on an anatomic study, a transfer of the brachialis muscle branch of the musculocutaneous nerve (BMBMCN) to finger flexor functional fascicles of the median nerve was designed. Preliminary results of clinical application of this new procedure are reported. Dissection of 32 cadaver upper limbs revealed that BMBMCN...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20053
更新日期:2004-01-01 00:00:00
abstract::By applying a novel biochemical technique using porcine tendon as the raw material with its antigen minimized, we developed an artificial biological ligament (ABL). We examined and tested its structure, mechanical properties, and biocompatibility and explored the feasibility of reconstructing the anterior cruciate lig...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20442
更新日期:2008-01-01 00:00:00
abstract::Replantation of amputated rat feet utilizing an efferent arteriovenous shunt constructed between the distal posterior tibial artery and the proximal posterior tibial vein, in the absence of all other venous drainage, provides an alternative pathway to the normal venous drainage in a replanted rat foot. However, this s...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920130112
更新日期:1992-01-01 00:00:00
abstract::Free microvascular tissue transfers have become today a key instrument for the surgical treatment of wide loss of tissue. These procedures can provide definitive treatment in a single operation but they are expensive and require specialized practitioners. The operating microscope traditionally has provided this requir...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20399
更新日期:2007-01-01 00:00:00
abstract::In a digital degloving injury of four fingers, a combined treatment of tripedicle dermal flap, free hemipulp web flap, and skin graft was used. The functional and cosmetic results of the hand were satisfactory. The patient had an excellent sensory recovery in the free hemipulp web flap and did not complain of any disa...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/(sici)1098-2752(1998)18:3<172::aid-micr9>3
更新日期:1998-01-01 00:00:00
abstract::Improved microsurgical techniques for kidney transplantation in the mouse are described. Left renal transplantation is performed with end-to-side anastomoses of the donor renal vein to the inferior vena cava and the donor aortic cuff to the aorta. Urinary tract reconstruction is accomplished by suturing the donor uret...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920160212
更新日期:1995-01-01 00:00:00
abstract::Two hundred twenty patients with soft tissue defects in the hand and forearm were treated with 226 free and island flap transfers. Reconstructed sites involved the thumb in 74 cases, the fingers in 117, the hand in 30, and the forearm in 5. Seventy-nine patients received 82 free flaps, and 141 patients received 144 is...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/(SICI)1098-2752(1996)17:3<150::AID-MICR10>
更新日期:1996-01-01 00:00:00
abstract::Lymphedema most commonly occurs after cancer treatment and can affect limbs and genitalia. Genital lymphedema (GL) is a rare condition and can be disabling psychologically and physically. It often occurs along with lower extremity lymphedema (LEL). Conservative and physiologic reconstructive surgery such as lymphatico...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.30331
更新日期:2018-11-01 00:00:00
abstract::The authors present a new technique of end-to-side microvascular anastomosis in a rat carotid artery model, employing a milliwatt CO2 laser. Both carotid arteries were isolated and approximated in an end-to-side fashion by the placement of four 10-0 nylon stay sutures. The milliwatt CO2 laser was used to effect vessel...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920070206
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Composite defects of bone and soft tissues represent a reconstructive challenge. Several techniques have been described in the medical literature; however, extensive composite defects should be reconstructed with microvascular free tissue transfer. The purpose of this report is to present the use of a compos...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.22067
更新日期:2013-03-01 00:00:00
abstract::Combination of tissue expansion and perforator flaps broadened the reconstructive options in burn cases with wide scar contractures. We report a case of total aesthetic subunit reconstruction of the anterior abdominal skin using a pre-expanded pedicled anterolateral thigh (ALT) perforator flap in a patient with postbu...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.30519
更新日期:2019-11-01 00:00:00
abstract::Current methods of peripheral nerve repair are to rejoin cut nerve stumps directly or to bridge large gaps with autologous nerve grafts. In both cases the surface of nerve stump endings is typically cut perpendicularly to the long axis of the nerve. The outcome of such operations, however, is still not satisfactory. I...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20290
更新日期:2006-01-01 00:00:00
abstract::We present herein a case of massive arterial thrombosis of a free rectus abdominal musculocutaneous flap used for reconstructive surgery of gingival carcinoma that could not be rescued. A 54-year-old woman underwent the operation. She had experienced two miscarriages in her 20s, but medical history was otherwise uneve...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20734
更新日期:2010-01-01 00:00:00
abstract::The use of bulky retractors in experimental microsurgical procedures creates interference with the limited operative field. The current article describes a small but effective retractor made from ordinary staples, which are inexpensive and easily accessible. ...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920080416
更新日期:1987-01-01 00:00:00
abstract::Cryopreservation of organs has been investigated to sustain the reproductive function of patients undergoing sterilizing chemotherapy and radiotherapy or reproductive surgery. A modified protocol for whole organ cryopreservation was described and the outcome of cryopreservative ovaries was evaluated, and apoptosis of ...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20516
更新日期:2008-01-01 00:00:00
abstract::This study describes our experience using an improved technique for microsurgical sleeve anastomosis of arteries. Modifications of previously described techniques include utilization of a sidecut and placement of the two stitches within separate vertical planes. In 40 arteries, we attained a patency rate of 97.5%. His...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920120502
更新日期:1991-01-01 00:00:00
abstract::A 4-year-old girl who sustained the hemiplegic cerebral palsy and subsequent spasticity in the left upper extremity underwent the C7 nerve root rhizotomy and the contralateral C7 nerve root transfer to the ipsilateral middle trunk of brachial plexus through an interpositional sural nerve graft. In a 2-year follow-up, ...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.20877
更新日期:2011-07-01 00:00:00
abstract::To evaluate the natural course of postsurgical adhesion formation, a descriptive animal study was performed in a standardized rat adhesion model, involving the uterine horn and peritoneal side wall. Extent and type of postsurgical adhesion formation was evaluated at increasing postoperative time intervals up to 1 year...
journal_title:Microsurgery
pub_type: 杂志文章
doi:10.1002/micr.1920160912
更新日期:1995-01-01 00:00:00