Carcinogenesis in reflux disease--in search for bile-specific effects.

Abstract:

:Bile reflux may play a key role for esophageal carcinogenesis in reflux disease. In search for bile-specific effects, the animal model of esophageal cancer was applied in a mutagenesis assay. Big Blue transgenic mice were operated with microsurgical techniques. Seven had total gastrectomy with esophagojejunostomy creating esophageal reflux of bile and five had a sham operation. After 24 weeks, the mutation frequency (MF) was measured through standard Big Blue mutagenesis assay in the esophageal mucosa and the duodenum as control. Esophageal reflux resulted in esophagitis in the distal esophagus. The MF in esophageal mucosa was 1.6 times higher in animals with reflux than in sham-operated animals; it was identical in the duodenum. In conclusion, the mutagenic potential of bile reflux has been confirmed. However, mechanisms of carcinogenesis in the esophageal cancer model other than chronic inflammation could not be identified because of the only moderately increased MF.

journal_name

Microsurgery

journal_title

Microsurgery

authors

Fein M,Peters JH,DeMeester TR

doi

10.1002/micr.20424

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

647-50

issue

8

eissn

0738-1085

issn

1098-2752

journal_volume

27

pub_type

杂志文章
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