End-to-side neurorrhaphy.

Abstract:

:End-to-side neurorrhaphy, a possible strategy for treating nerve lesions without useable proximal nerve stumps, has been experimentally and clinically investigated. In end-to-side neurorrhaphy, three main elements should be considered: 1) the induction of axonal collateral sprouting in the donor nerve; 2) the ability of the collateral axons to pierce the different conjunctival layers, including the ability the donor nerve basal laminae, to reinnervate the recipient nerve; and 3) the functional plasticity and behavioral readjustment of single motoneurons that have eventually adopted new motor units. This article reviews the following areas of research and clinical investigation: animal models, axonal collateral sprouting from end-to-side neurorrhaphy, effect of epineurotomy and perineurotomy on axon regeneration, motor reinnervation, and clinical trials.

journal_name

Microsurgery

journal_title

Microsurgery

authors

Zhang F,Fischer KA

doi

10.1002/micr.21736

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

122-7

issue

3

eissn

0738-1085

issn

1098-2752

journal_volume

22

pub_type

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