Abstract:
:End-to-side neurorrhaphy, a possible strategy for treating nerve lesions without useable proximal nerve stumps, has been experimentally and clinically investigated. In end-to-side neurorrhaphy, three main elements should be considered: 1) the induction of axonal collateral sprouting in the donor nerve; 2) the ability of the collateral axons to pierce the different conjunctival layers, including the ability the donor nerve basal laminae, to reinnervate the recipient nerve; and 3) the functional plasticity and behavioral readjustment of single motoneurons that have eventually adopted new motor units. This article reviews the following areas of research and clinical investigation: animal models, axonal collateral sprouting from end-to-side neurorrhaphy, effect of epineurotomy and perineurotomy on axon regeneration, motor reinnervation, and clinical trials.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Zhang F,Fischer KAdoi
10.1002/micr.21736subject
Has Abstractpub_date
2002-01-01 00:00:00pages
122-7issue
3eissn
0738-1085issn
1098-2752journal_volume
22pub_type
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