The effect of contrast media of low osmolality on the peripheral arterial blood flow in the dog.

Abstract:

:The intravascular contrast media in current use are solutions of salts of tri-iodinated substituted benzoic acids. Haemodynamic changes following injection of these contrast media are due mainly to their high osmolar concentration which is five to eight times physiological levels. In this study we compare the effect in dogs on femoral arterial flow following femoral arterial injection of three new low osmolality contrast media (Amipaque, Iopamidol and Hexabrix) compared to conventional contrast media (Coronary 280). Conventional salts such as Conray 280 cause a marked vasodilatation and increase in femoral blood flow to about twice pre-injection levels. The three new low osmolality contrast media cause much less vasodilation and increase in femoral blood flow (+32%). There was no significant difference between the effects of any of the three new media. The experiment suggests that any of three new low osmolality contrast media should be suitable for femoral arteriography as they cause much less vasodilatation (and therefore discomfort) than conventional contrast media. Our results do not indicate a preference for any of the three new contrast agents.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Steiner RM,Grainger RG,Memon N,Weiss D,Kanofsky PB,Menduke H

doi

10.1016/s0009-9260(80)80001-8

subject

Has Abstract

pub_date

1980-11-01 00:00:00

pages

621-7

issue

6

eissn

0009-9260

issn

1365-229X

journal_volume

31

pub_type

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