Stimulation of sodium and of chloride transport in epithelia by forskolin.

abstract：:1 Non-adrenergic non-cholinergic (NANC) vasodilator nerves regulate tone in certain vascular beds. We have investigated the mechanisms of the NANC dilator response in the isolated small mesenteric artery of the rabbit by use of the tension myograph. 2 Small second or third order (150-300 microm in diameter) arteries o...

journal_title：British journal of pharmacology

authors： Kakuyama M,Vallance P,Ahluwalia A

更新日期：1998-01-01 00:00:00

abstract：:1 The presynaptic alpha-adrenoceptor blocking activity of the newly synthesized alpha-adrenoceptor blocking drug, benextramine, was evaluated in the isolated left atrium of the guinea-pig heart. 2 High-voltage stimulation increased the force of contraction of electrically driven atrial strips, presumably by releasing ...

journal_title：British journal of pharmacology

authors： Belleau B,Benfey BG,Melchiorre C

更新日期：1982-04-01 00:00:00

abstract：:1. The interaction between endogenous nitric oxide (NO) and factors from the rat submandibular salivary gland such as epidermal growth factor (EGF) on gastric mucosal integrity in the rat has been investigated. 2. Bolus administration of the NO synthase inhibitor, NG nitro-L-arginine methyl ester (L-NAME; 6.25-50 mg k...

journal_title：British journal of pharmacology

authors： Tepperman BL,Soper BD

更新日期：1993-09-01 00:00:00

abstract：:1. We have shown earlier that pilocarpine strongly inhibits mouse and human liver coumarin 7-hydroxylase activity of CYP 2A and pentoxyresorufin O-deethylase activity of CYP 2B in vitro. Since pilocarpine, like coumarin, contains a lactone structure we have studied in more detail its inhibitory potency on mouse and hu...

journal_title：British journal of pharmacology

authors： Kinonen T,Pasanen M,Gynther J,Poso A,Järvinen T,Alhava E,Juvonen RO

更新日期：1995-11-01 00:00:00

abstract：UNLABELLED:Reorganization of the actin cytoskeleton is essential for cell motility and chemotaxis. Actin-binding proteins (ABPs) and membrane lipids, especially phosphoinositides PI(4,5)P2 and PI(3,4,5)P3 are involved in the regulation of this reorganization. At least 15 ABPs have been reported to interact with, or reg...

journal_title：British journal of pharmacology

authors： Wu CY,Lin MW,Wu DC,Huang YB,Huang HT,Chen CL

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cloxyquin (5-cloroquinolin-8-ol) has been described as an activator of TRESK (K2P 18.1, TWIK-related spinal cord K+ channel) background potassium channel. We have examined the specificity of the drug by testing several K2P channels. We have investigated the mechanism of cloxyquin-mediated TRESK a...

journal_title：British journal of pharmacology

authors： Lengyel M,Dobolyi A,Czirják G,Enyedi P

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Angiotensin II (AngII) induces migration and growth of vascular smooth muscle cell (VSMC), which is responsible for vascular remodelling in some cardiovascular diseases. Ang II also activates a Cl(-) current, but the underlying mechanism is not clear. EXPERIMENTAL APPROACH:The A10 cell line and ...

journal_title：British journal of pharmacology

authors： Ma MM,Lin CX,Liu CZ,Gao M,Sun L,Tang YB,Zhou JG,Wang GL,Guan YY

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Strontium ranelate reduces fracture risk in postmenopausal women with osteoporosis. Evidence from non-clinical studies and analyses of bone markers in phase III trials indicate that this is due to an increase in osteoblast formation and a decrease of osteoclastic resorption. The aim of this work ...

journal_title：British journal of pharmacology

authors： Brennan TC,Rybchyn MS,Green W,Atwa S,Conigrave AD,Mason RS

更新日期：2009-08-01 00:00:00

abstract：:1. Neurogenic responses to transmural electrical stimulation were examined in endothelium-denuded extrameningeal (vertebral and carotid) and intrameningeal (spinal, basilar and middle cerebral) arteries isolated from dogs. 2. In the extrameningeal arteries, transmural electrical stimulation produced a phasic contracti...

journal_title：British journal of pharmacology

authors： Kohno Y,Saito T,Saito H,Aoyama H,Nojyo Y,Kigoshi S,Muramatsu I

更新日期：1995-11-01 00:00:00

abstract：:1 The effect of compound 48/80 was studied on the twitch-like contractions of the longitudinal muscle of guinea-pig ileum induced by electrical stimulation of intramural cholinergic nerves. 2 Compound 48/80 alone, at concentrations up to 30 microgram/ml, had no effect on the twitch contractions. The contraction to exo...

journal_title：British journal of pharmacology

authors： Kamikawa Y,Shimo Y

更新日期：1978-12-01 00:00:00

abstract：:1. The effects of several agonists of the metabotropic glutamate receptor (mGluR) were studied in adult rat striatal slices by measuring (i) KCl (30 mM)-induced output of previously taken up D-[3H]-aspartate (Asp), (ii) forskolin (30 microM)-induced adenosine 3':5'-cyclic monophosphate (cyclic AMP) accumulation and (i...

journal_title：British journal of pharmacology

authors： Lombardi G,Alesiani M,Leonardi P,Cherici G,Pellicciari R,Moroni F

更新日期：1993-12-01 00:00:00

abstract：:1. We investigated how microsomal cytochrome P450 mono-oxygenase (Cyp450 MO) is regulated in cultured porcine aortic endothelial cells. The hypothesis that a Cyp450 MO-derived metabolite links Ca2+ store depletion and Ca2+ entry was studied further. 2. Microsomal Cyp450 MO was monitored fluorometrically by dealkylatio...

journal_title：British journal of pharmacology

authors： Hoebel BG,Kostner GM,Graier WF

更新日期：1997-08-01 00:00:00

abstract：:The binding of DL-[3,4-3H] 2-amino-4-phosphonobutyric acid DL[3H]-APB to rat whole brain synaptic membranes was investigated. Binding was linear with membrane protein concentration, and optimal at physiological pH and temperature. The association rate was rapid, achieving equilibrium within 10 min. Prolonged incubatio...

journal_title：British journal of pharmacology

authors： Butcher SP,Collins JF,Roberts PJ

更新日期：1983-10-01 00:00:00

abstract：:The effect of activation of protein kinase C (PKC) or adenylyl cyclase on release of glutamate has been investigated in a perfused slice preparation from the rat caudal trigeminal nucleus. Stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) produced a concentration-dependent increase in K(+)-evoked release of ...

journal_title：British journal of pharmacology

authors： Maneuf YP,McKnight AT

更新日期：2001-09-01 00:00:00

abstract：:1. The NK1 tachykinin receptor agonists, septide, [Sar9,Met(O2)11]SP and [Pro9]SP produced locomotor hyperactivity (10-20 min) when injected intracerebroventricularly (i.c.v.) in the guinea-pig. The most potent in eliciting this hyperactivity was septide (from 0.63 to 5 micrograms), compared to [Sar9,Met(O2)11]SP, whi...

journal_title：British journal of pharmacology

authors： Piot O,Betschart J,Grall I,Ravard S,Garret C,Blanchard JC

更新日期：1995-11-01 00:00:00

abstract：:The interaction of ketamine with the 5-HT3 receptor of rabbit nodose ganglion neurones is described. Ketamine (3-30 microM) enhanced 5-HT3 receptor-mediated currents recorded under voltage-clamp conditions. This action did not appear to be related to the known effect of ketamine of inhibiting 5-HT uptake. ...

journal_title：British journal of pharmacology

authors： Peters JA,Malone HM,Lambert JJ

更新日期：1991-07-01 00:00:00

abstract：:1. Nine non-steroidal anti-inflammatory drugs were tested for antagonism of bradykinin-induced bronchoconstriction in guinea-pig lungs in vivo. Only one, benzydamine, was inactive.2. The descending order of potency of the active anti-inflammatory drugs was meclofenamate = Scha 306>Scha 87/2>indoxole>Mi85>indomethacin>...

journal_title：British journal of pharmacology

authors： Collier HO,James GW,Piper PJ

更新日期：1968-09-01 00:00:00

abstract：:1. The type of endothelin (ET) receptor located on the myenteric neurones of guinea-pig ileum was determined by receptor autoradiography and function of the receptor was examined by release experiments of acetylcholine (ACh) from the longitudinal muscle myenteric plexus (LM-MP) preparations. 2. Specific [125I]-ET-1 bi...

journal_title：British journal of pharmacology

authors： Yoshimura M,Yamashita Y,Kan S,Niwa M,Taniyama K

更新日期：1996-07-01 00:00:00

abstract：:1. The modification by Bay K 8644 of the vasodilator effects of nifedipine, diltiazem, nicorandil and nitroglycerin was investigated in the femoral arterial bed of anaesthetized dogs. 2. The right femoral artery was cannulated and its arterial bed was perfused with autologous blood at a constant pressure slightly high...

journal_title：British journal of pharmacology

authors： Sato Y,Ishii K,Taira N

更新日期：1988-01-01 00:00:00

abstract：:To evaluate the role of G-protein-coupled receptor kinases (GRK) in the desensitization of the histamine H(2) receptor, the H(2) receptor was transiently cotransfected with GRK2, 3, 5 or 6 in COS-7 cells and the cyclic AMP levels in response to histamine were studied. Coexpression of the H(2) receptor with GRK2 and 3 ...

journal_title：British journal of pharmacology

authors： Rodriguez-Pena MS,Timmerman H,Leurs R

更新日期：2000-12-01 00:00:00

abstract：:1. Immunohistochemical and functional studies have been performed to localize and determine the effects of neuropeptide Y (NPY) in the rat seminal vesicle. 2. An abundant presence of NPY-immunoreactive nerves, mainly concentrated in the smooth muscle layer of the seminal vesicle was found. Chronic 6-hydroxydopamine tr...

journal_title：British journal of pharmacology

authors： Iravani MM,Zar MA

更新日期：1994-11-01 00:00:00

abstract：:Administration of catechol to rats anaesthetized with urethane produces a central excitatory state during which an EMG consisting of three temporally distinct components (M1, M2 and M3) can be recorded from forelimb and hindlimb muscles to electrical stimulation of cutaneous afferents. The probability of occurrence of...

journal_title：British journal of pharmacology

authors： Dewhurst DG

更新日期：1984-09-01 00:00:00

abstract：:1. The role of nitic oxide (NO) derived from L-arginine in the regional vasodilator effects of endothelin-1 has been investigated in anaesthetized, spontaneously hypertensive (SH) rats in which autonomic reflexes were abolished by ganglion blockade. The experimental design incorporated animals infused with phenylephri...

journal_title：British journal of pharmacology

authors： Fozard JR,Part ML

更新日期：1992-03-01 00:00:00

abstract：:1. Both in mammalian tissues and in transfected cells, only low levels of alpha1D-adrenoceptors are detected in radioligand binding studies. It has been implicated that the comparatively long N-terminal tail of the alpha1D-adrenoceptor is responsible for the inefficient surface expression of the receptor. 2. In the pr...

journal_title：British journal of pharmacology

authors： Petrovska R,Kapa I,Klovins J,Schiöth HB,Uhlén S

更新日期：2005-03-01 00:00:00

abstract：:1. Patients with airway infection by Pseudomonas aeruginosa have impaired mucociliary clearance. Pyocyanin is a phenazine pigment produced by P. aeruginosa which is present in the sputum of colonized patients, slows human ciliary beat frequency (CBF) in vitro and slows mucociliary transport in vivo in the guinea-pig. ...

journal_title：British journal of pharmacology

authors： Kanthakumar K,Cundell DR,Johnson M,Wills PJ,Taylor GW,Cole PJ,Wilson R

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The effects of bergamot essential oil (BEO; Citrus bergamia, Risso) on excitotoxic neuronal damage was investigated in vitro. EXPERIMENTAL APPROACH:The study was performed in human SH-SY5Y neuroblastoma cells exposed to N-methyl-D-aspartate (NMDA). Cell viability was measured by dye exclusion. R...

journal_title：British journal of pharmacology

authors： Corasaniti MT,Maiuolo J,Maida S,Fratto V,Navarra M,Russo R,Amantea D,Morrone LA,Bagetta G

更新日期：2007-06-01 00:00:00

abstract：:1. A wide panel of compounds acting on beta-adrenoceptors active either in mammalian heart or in rodent digestive tract and adipose tissues, were investigated for their effects on Chinese hamster ovary cells transfected with the human or murine beta 3-adrenoceptor gene. 2. The beta 3-agonists, bucindolol, CGP 12177A a...

journal_title：British journal of pharmacology

authors： Blin N,Nahmias C,Drumare MF,Strosberg AD

更新日期：1994-07-01 00:00:00

abstract：:In this issue MacMillan and McCarron in 2010 demonstrated that the phospholipase C (PLC) inhibitor U-73122 can potently inhibit Ca(2+) release from isolated smooth muscle cells independent of its effect on PLC. Their data suggest that the PLC inhibitor can block the sarcoplasmic/endoplasmic reticulum calcium ATPase pu...

journal_title：British journal of pharmacology

authors： Hollywood MA,Sergeant GP,Thornbury KD,McHale NG

更新日期：2010-07-01 00:00:00

abstract：:The effects of 10 mM caffeine (CAF) on intramembrane charge movements (ICM) were studied in isolated guinea-pig ventricular heart cells with the whole-cell patch-clamp technique. In the presence of CAF, the properties (voltage dependence, maximum Q(ON) [Q(max)], availability with voltage) of Q(ON) charge activated fro...

journal_title：British journal of pharmacology

authors： Leroy J,Lignon JM,Gannier F,Argibay JA,Malécot CO

更新日期：2002-02-01 00:00:00

abstract：:1. In decerebrated, non-spinalized rabbits, intrathecal administration of either of the selective 5-HT1A-receptor antagonists (S)WAY-100135 or WAY-100635 resulted in dose-dependent enhancement of the reflex responses of gastrocnemius motoneurones evoked by electrical stimulation of all myelinated afferents of the sura...

journal_title：British journal of pharmacology

authors： Clarke RW,Harris J,Houghton AK

更新日期：1996-11-01 00:00:00