Differential antagonism by Bay K 8644 of vasodilator effects of nifedipine, diltiazem, nicorandil and nitroglycerin in dog femoral circulation.

abstract：:Phytoestrogens are plant-derived dietary compounds with structural similarity to 17-β-oestradiol (E2), the primary female sex hormone. This structural similarity to E2 enables phytoestrogens to cause (anti)oestrogenic effects by binding to the oestrogen receptors. The aim of the present review is to present a state-of...

journal_title：British journal of pharmacology

authors： Rietjens IMCM,Louisse J,Beekmann K

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Agonists of the M(2) muscarinic acetylcholine receptor (mAChR) increase mRNA for this receptor and mRNA for endothelial and neuronal isoforms of NO synthase (eNOS or nNOS). Here we examine the different signalling pathways involved in such events in rat cardiac atria. EXPERIMENTAL APPROACH:In is...

journal_title：British journal of pharmacology

authors： Ganzinelli S,Joensen L,Borda E,Bernabeo G,Sterin-Borda L

更新日期：2007-05-01 00:00:00

abstract：:1. In the neuronally isolated cortex of the cat, local application of bemegride, picrotoxin, nikethamide, caffeine and strychnine facilitated the surface positive response of the isolated cortex and lowered the stimulus threshold for this response. Excepting nikethamide, they all produced convulsive discharge in the i...

journal_title：British journal of pharmacology

authors： Frank GB,Jhamandas K

更新日期：1970-08-01 00:00:00

abstract：:1. The effects of the two enantiomers, quinidine and quinine, were studied on depolarization- and agonist-induced isometric contractions in rat isolated thoracic aortic rings. 2. Quinidine or quinine (10(-6)M-3 x 10(-4)M) produced a concentration-dependent relaxation of 80 mM KCl-contracted rings, the pD2 values being...

journal_title：British journal of pharmacology

authors： del Pozo BF,Pérez-Vizcaíno F,Villamor E,Zaragozá F,Tamargo J

更新日期：1996-01-01 00:00:00

abstract：:The mechanism underlying the LTC(4)-induced contraction of guinea-pig taenia coli was determined using the simultaneous measurements of [Ca(2+)](i) and force in whole muscle preparations. Additional experiments were performed in receptor coupled permeabilized preparation. For comparison purposes, the contraction which...

journal_title：British journal of pharmacology

authors： Ieiri S,Nishimura J,Hirano K,Suita S,Kanaide H

更新日期：2001-06-01 00:00:00

abstract：:The chronic morphine-induced inhibition of rat liver tryptophan pyrrolase activity and the resultant increases in tryptophan availability to the brain and brain 5-hydroxytryptamine (5-HT) synthesis are reversed within 10 min after naloxone administration. The possible involvement of hepatic tryptophan metabolism in mo...

journal_title：British journal of pharmacology

authors： Badawy AA,Evans M

更新日期：1981-11-01 00:00:00

abstract：:By examination of compound action potentials in the saphenous nerve of the anaesthetized rat it has been shown that capsaicin causes a rapid, dose-dependent, failure of conduction in many C-fibres when applied directly to the nerve. A large reduction in C-fibre conduction occurs with concentrations as low as 110 micro...

journal_title：British journal of pharmacology

authors： Baranowski R,Lynn B,Pini A

更新日期：1986-10-01 00:00:00

abstract：:We investigated the rate of penetration into and the intra-relationship between the serum, cerebrospinal fluid (CSF) and regional brain extracellular fluid (bECF) compartments following systemic administration of lamotrigine in rat. The serum pharmacokinetics were biphasic with an initial distribution phase, (half-lif...

journal_title：British journal of pharmacology

authors： Walker MC,Tong X,Perry H,Alavijeh MS,Patsalos PN

更新日期：2000-05-01 00:00:00

abstract：:1. We investigated the cytoprotective effect of low-dose nitric oxide (NO) on NO-induced cell death in mouse macrophage-like cell line RAW264. 2. Sodium nitroprusside (SNP), an NO donor, at a high concentration (4 mM) released cytochrome c from mitochondria and induced death in RAW264 cells. Acetyl-L-aspartyl-L-glutam...

journal_title：British journal of pharmacology

authors： Yoshioka Y,Yamamuro A,Maeda S

更新日期：2003-05-01 00:00:00

abstract：:1. A biliary fistula was prepared in twelve sheep.2. Each animal was given 2 ml. of (14)C-carbon tetrachloride (specific activity 15 mc/m-mole) and bile collected at 2, 4, 24 and 48 hr.3. Specific activity was measured by liquid scintillation counting before and after each specimen had been heated to 75 degrees C for ...

journal_title：British journal of pharmacology

authors： Khalidi A,Zaki SA

更新日期：1969-06-01 00:00:00

abstract：:The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more deta...

journal_title：British journal of pharmacology

authors： Alexander SP,Christopoulos A,Davenport AP,Kelly E,Marrion NV,Peters JA,Faccenda E,Harding SD,Pawson AJ,Sharman JL,Southan C,Davies JA,CGTP Collaborators.

更新日期：2017-12-01 00:00:00

abstract：:1. The effects of beta-adrenoceptor blockade on the changes in plasma renin activity (PRA) following angiotensin enzyme (ACE) inhibition were investigated in pentobarbitone-chloralose anaesthetized dogs. 2. ACE-inhibition, with enalapril (2 mg kg-1), caused a significant reduction in systemic arterial blood pressure (...

journal_title：British journal of pharmacology

authors： Cambridge D,Whiting MV,Butterfield LJ,Allan G

更新日期：1992-06-01 00:00:00

abstract：:1. The mechanisms by which nicorandil causes relaxation of rat isolated small mesenteric arteries mounted on a Mulvany myograph was investigated by use of a combination of putatively mechanism-specific antagonists. 2. In arteries precontracted by the thromboxane-mimetic, U46619, the EC50 for cromakalim and levcromakal...

journal_title：British journal of pharmacology

authors： Fujiwara T,Angus JA

更新日期：1996-12-01 00:00:00

abstract：:1. We studied the biochemical and contractile responses of isolated human myocardial tissue expressing native receptor variants of the 389G>R beta(1)-adrenoceptor polymorphism. 2. Right atrial appendage was obtained from homozygous RR patients (n=37) and homozygous GG patients (n=17) undergoing elective cardiac surger...

journal_title：British journal of pharmacology

authors： Sandilands AJ,O'Shaughnessy KM,Brown MJ

更新日期：2003-01-01 00:00:00

abstract：:In electrophysiological measurements the beta-carboline ethyl 6-benzyloxy-beta-carboline-3-carboxylate (ZK 91085) acts as a positive allosteric modulator on rat recombinant alpha1beta2gamma2 GABA(A) receptors and binds with high affinity (IC50-1.5 nM) to the [3H]-flunitrazepam site. Flumazenil was able to partially co...

journal_title：British journal of pharmacology

authors： Thomet U,Baur R,Scholze P,Sieghart W,Sigel E

更新日期：1999-07-01 00:00:00

abstract：:The aim of this study was to investigate the structure-activity relationship of S-alkyl-L-isothiocitrulline-containing dipeptides towards three partially purified recombinant human nitric oxide synthase (NOS) isozymes, as well as the effects of these compounds on cytokine-induced NO production by human DLD-1 cells. In...

journal_title：British journal of pharmacology

authors： Park JM,Higuchi T,Kikuchi K,Urano Y,Hori H,Nishino T,Aoki J,Inoue K,Nagano T

更新日期：2001-04-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) is a relatively recently discovered molecule originating in the so-called L-cells of the intestine. The peptide has insulinotrophic properties and it is this characteristic that has predominantly been investigated. This has led to the use of the GLP-1-like peptide exendin-4 (EX-4), whic...

journal_title：British journal of pharmacology

authors： Harkavyi A,Whitton PS

更新日期：2010-02-01 00:00:00

abstract：:1. The action of adrenaline on the K(+) balance of the isolated heart was found to depend on the ionic composition and the temperature of the perfusion fluids used.2. When the perfusion fluid contained 145 mM Na(+), 1.7 mM Ca(++) and 3-9 mM K(+), adrenaline caused the hearts to gain K(+); when the K(+) concentration w...

journal_title：British journal of pharmacology

authors： Stafford A

更新日期：1969-07-01 00:00:00

abstract：:1. The release of 5-hydroxytryptamine (5-HT) from the cerebral cortex and caudate nucleus of brainstem-transected cats and from the cerebral cortex of rats anaesthetized with urethane was determined by radioenzymatic and biological assay. 2. The stimulation of nucleus linearis intermedius of raphe doubles the basal 5-...

journal_title：British journal of pharmacology

authors： Aiello-Malmberg P,Bartolini A,Bartolini R,Galli A

更新日期：1979-04-01 00:00:00

abstract：:1. Lowering of the extracellular Mg(2+)-concentration induces various patterns of epileptiform activity in combined rat entorhinal cortex-hippocampal brain slices. After a prolonged period of exposure to Mg(2+)-free medium seizure-like events in the entorhinal cortex change to a state of late recurrent discharges whic...

journal_title：British journal of pharmacology

authors： Pfeiffer M,Draguhn A,Meierkord H,Heinemann U

更新日期：1996-10-01 00:00:00

abstract：:1. The present study was designed to characterize the nociceptive response induced by protein kinase C (PKC) peripheral activation and to investigate if this biochemical event is important for the nociceptive response induced by formaldehyde, and bradykinin (BK). 2. Intraplantar injection of phorbol-12,13-didecanoate ...

journal_title：British journal of pharmacology

authors： Souza AL,Moreira FA,Almeida KR,Bertollo CM,Costa KA,Coelho MM

更新日期：2002-01-01 00:00:00

abstract：:The POZ domain Krüppel-like zinc finger transcription repressor (POK family) contains many important molecules, including RP58, Bcl6 and PLZF. They function as transcription repressors via chromatin remodelling and histone deacetylation and are known to be involved in the development and tumourigenesis of various orga...

journal_title：British journal of pharmacology

authors： Okado H

更新日期：2020-09-22 00:00:00

abstract：:1. The relationships between the density of dopamine D4.4 receptors and the agonist efficacies of L-745,870 (3-(4-[4-chlorophhenyl]piperazin-1-yl)-methyl-1H-pyrrolo [2, 3-b]pyridine) and U-101958 ((1-benzyl-piperidin-4-yl)-(3-isopropoxy-pyridin-2-yl)-methyl-a min e) were investigated in Chinese hamster ovary (CHO) cel...

journal_title：British journal of pharmacology

authors： Gazi L,Bobirnac I,Danzeisen M,Schüpbach E,Langenegger D,Sommer B,Hoyer D,Tricklebank M,Schoeffter P

更新日期：1999-10-01 00:00:00

abstract：:1. Endothelin, a novel potent vasoconstrictor peptide produced by vascular endothelial cells stimulated anion secretion by a cultured secretory epithelium derived from the rat epididymis as measured by changes in short-circuit current (SCC). 2. Stimulation of the SCC was observed when endothelin was added to the basol...

journal_title：British journal of pharmacology

authors： Wong PY,Fu WO,Huang SJ

更新日期：1989-12-01 00:00:00

abstract：:1. Using gene chip technology, we first identified that PGF(2alpha) (FP agonist) and Butaprost (EP(2) agonist) induced about a five-fold upregulation of Nur77 mRNA expression in hFP-HEK 293/EBNA and hEP(2)-HEK293/EBNA cells. Northern Blot analysis revealed that PGF(2alpha)- and Butaprost-induced upregulation of Nur77 ...

journal_title：British journal of pharmacology

authors： Liang Y,Li C,Guzman VM,Chang WW,Evinger AJ,Pablo JV,Woodward DF

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Uridine 5'-triphosphate (UTP) is a potent vasoconstrictor of cerebral arteries and induces Ca(2+) waves in vascular smooth muscle cells (VSMCs). This study aimed to determine the mechanisms underlying UTP-induced Ca(2+) waves in VSMCs of the rat basilar artery. EXPERIMENTAL APPROACH:Isometric fo...

journal_title：British journal of pharmacology

authors： Syyong HT,Yang HH,Trinh G,Cheung C,Kuo KH,van Breemen C

更新日期：2009-02-01 00:00:00

abstract：:The chemical trimethylcyclohexanol (TMC) is closely related to menthol, the major component of a terpene preparation with known choleretic and cholelitholytic activity. Its effects on hepatic cholesterol synthesis and bile secretion were examined in the rat. In both acute and long-term dosing experiments TMC significa...

journal_title：British journal of pharmacology

authors： Bell GD,Clegg RJ,Ellis WR,Middleton B,White DA

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A putative novel cannabinoid receptor mediates vasorelaxation to anandamide and abnormal-cannabidiol and is blocked by O-1918 and by high concentrations of rimonabant. This study investigates VSN16, a novel water-soluble agonist, as a vasorelaxant potentially acting at non-CB1, non-CB2 cannabinoi...

journal_title：British journal of pharmacology

authors： Hoi PM,Visintin C,Okuyama M,Gardiner SM,Kaup SS,Bennett T,Baker D,Selwood DL,Hiley CR

更新日期：2007-11-01 00:00:00

abstract：:1. Pharmacological inhibitors of protein kinase A (PKA) and protein phosphatases 1/2A were used to determine whether basal L-type Ca(2+) current (I(Ca)) observed in the absence of exogenous beta-adrenergic receptor stimulation is sustained by PKA-mediated phosphorylation. Amphotericin B was used to record whole-cell I...

journal_title：British journal of pharmacology

authors： Bracken N,Elkadri M,Hart G,Hussain M

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tooth eruption is a complicated process regulated by the dental follicles (DF). Our recent study discovered that tooth eruption was inhibited upon injection of bleomycin into DF. However, the mechanisms were unknown. EXPERIMENTAL APPROACH:Human dental follicle cells (hDFCs) were treated by bleom...

journal_title：British journal of pharmacology

authors： Li ZZ,Wang HT,Lee GY,Yang Y,Zou YP,Wang B,Gong CJ,Cai Y,Ren JG,Zhao JH

更新日期：2020-10-17 00:00:00