Endothelin stimulates short circuit current in a cultured epithelium.

abstract：BACKGROUND AND PURPOSE:GPR18 is a recently deorphaned lipid receptor that is activated by the endogenous lipid N-arachidonoyl glycine (NAGly) as well the behaviourally inactive atypical cannabinoid, abnormal cannabidiol (Abn-CBD). The presence and/or function of any GPR18-based ocular signalling system remain essential...

journal_title：British journal of pharmacology

authors： Caldwell MD,Hu SS,Viswanathan S,Bradshaw H,Kelly ME,Straiker A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is growing evidence that inflammation plays a major role in the pathogenesis of neural damage caused by deposition of amyloid β (Aβ) in the brain. Nimodipine has received attention as a drug that might improve learning and reduce cognitive deficits in Alzheimer's disease, but the mechanism ...

journal_title：British journal of pharmacology

authors： Sanz JM,Chiozzi P,Colaianna M,Zotti M,Ferrari D,Trabace L,Zuliani G,Di Virgilio F

更新日期：2012-12-01 00:00:00

abstract：:The effects of N-(cyclopropylmethyl)-19-isopentylnororvinol hydrochloride (M320) on urine excretion by rats were investigated. Further studies, using rabbit isolated vas deferens, investigated its interactions with kappa-opiate receptors. The output of urine for a 2 h period after M320, administered subcutaneously to ...

journal_title：British journal of pharmacology

authors： Abrahams JM,Boura AL,Evans RG,Johnston CI,Olley JE

更新日期：1986-12-01 00:00:00

abstract：:1. The benzodiazepine site of the alpha 6 beta 2 gamma 2 subtype of gamma-aminobutyric acidA (GABAA) receptors is distinguishable from that of the alpha 1 beta 2 gamma 2 subtype by its inability to interact with classical benzodiazepines (i.e., diazepam) and its agonistic response to Ro 15-1788, which behaves as an an...

journal_title：British journal of pharmacology

authors： Im WB,Pregenzer JF,Binder JA,Alberts GL,Im HK

更新日期：1997-02-01 00:00:00

abstract：:1. Different 5-hydroxytryptamine (5-HT) receptor subtypes mediate different behavioural responses. Compounds acting at more than one 5-HT receptor exert behavioural effects which may be the result of response competition or a specific interaction between pathways within the CNS. Therefore the mutual interaction betwee...

journal_title：British journal of pharmacology

authors： Berendsen HH,Broekkamp CL

更新日期：1990-11-01 00:00:00

abstract：:1. The regulatory mechanism for the hypertrophy of skeletal muscles induced by clenbuterol is unclear. The purpose of the present study was to determine the extent to which transforming growth factor betas (TGFbetas), fibroblast growth factors (FGFs), hepatocyte growth factor (HGF), and platelet-derived growth factors...

journal_title：British journal of pharmacology

authors： Akutsu S,Shimada A,Yamane A

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Skeletal muscle is the predominant site for glucose disposal and fatty acid consumption. Emerging evidence indicates that the crosstalk between adipose tissue and skeletal muscle is critical in maintaining insulin sensitivity and lipid homeostasis. The current study was designed to investigate wh...

journal_title：British journal of pharmacology

authors： Shen S,Liao Q,Zhang T,Pan R,Lin L

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In endothelial dysfunction, signalling by nitric oxide (NO) is impaired because of the oxidation and subsequent loss of the soluble guanylyl cyclase (sGC) haem. The sGC activator 4-[((4-carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino)methyl[benzoic]acid (BAY 58-2667) is a haem-mimetic abl...

journal_title：British journal of pharmacology

authors： Hoffmann LS,Schmidt PM,Keim Y,Schaefer S,Schmidt HH,Stasch JP

更新日期：2009-07-01 00:00:00

abstract：:The effect of propranolol, a beta-adrenoceptor blocking agent, has been investigated on gastric acid secretion in pylorus and cardiac-ligated rats. Compared to the control group, propranolol significantly diminished the gastric acid secretion, and inhibited the formation of gastric ulceration. ...

journal_title：British journal of pharmacology

authors： Danhof IE,Geumei A

更新日期：1972-09-01 00:00:00

abstract：:1. Effects of an orally active non-peptide (BK) B2 receptor antagonist, FR173657 ((E)-3-(6-acetamido-3-pyridyl)-N-[N-[2,4-dichloro-3-[(2-methyl-8-quinoli nyl) oxymethyl]phenyl]-N-methylaminocarbonylmethyl] acrylamide) on the plasma exudation in rat carrageenin-induced pleurisy were investigated. 2. Plasma exudation in...

journal_title：British journal of pharmacology

authors： Majima M,Kawashima N,Hiroshi I,Katori M

更新日期：1997-06-01 00:00:00

abstract：:1. Human big-endothelin-1 (big-ET-1) and endothelin-1 (ET-1) are equipotent as pressor agents and produce a significant change in mean arterial blood pressure (MAP) in anaesthetized guinea-pigs (2 nmol kg-1: peak delta MAP: 23 +/- 6 mmHg and 26 +/- 5 mmHg, respectively). 2. Unlike big-ET-1, big-endothelin-3 (big-ET-3)...

journal_title：British journal of pharmacology

authors： D'Orléans-Juste P,Télémaque S,Claing A

更新日期：1991-10-01 00:00:00

abstract：:Phytoestrogens are plant-derived dietary compounds with structural similarity to 17-β-oestradiol (E2), the primary female sex hormone. This structural similarity to E2 enables phytoestrogens to cause (anti)oestrogenic effects by binding to the oestrogen receptors. The aim of the present review is to present a state-of...

journal_title：British journal of pharmacology

authors： Rietjens IMCM,Louisse J,Beekmann K

更新日期：2017-06-01 00:00:00

abstract：:1. We measured the effects of agonists and antagonists of metabotropic glutamate (mGlu) receptors (types 1 and 5) on NMDA-induced depolarization of mouse cortical wedges in order to characterize the mGlu receptor type responsible for modulating NMDA responses. We also characterized a number of mGlu receptor agents by ...

journal_title：British journal of pharmacology

authors： Attucci S,Carlà V,Mannaioni G,Moroni F

更新日期：2001-02-01 00:00:00

abstract：:1. The affinities of a number of alpha 1-adrenoceptor antagonists were determined by displacement of [3H]-prazosin binding from cloned human alpha 1A-adrenoceptors (previously designated cloned alpha 1c subtype), alpha 1B alpha 1D and rat alpha 1D-adrenoceptors, stably expressed in rat-1 fibroblasts. Functional affini...

journal_title：British journal of pharmacology

authors： Kenny BA,Chalmers DH,Philpott PC,Naylor AM

更新日期：1995-07-01 00:00:00

abstract：:Nociceptin (NC), alias Orphanin FQ, has been recently identified as the endogenous ligand of the opioid receptor-like 1 receptor (OP(4)). This new NC/OP(4) receptor system belongs to the opioid family and has been characterized pharmacologically with functional and binding assays on native (mouse, rat, guinea-pig) and...

journal_title：British journal of pharmacology

authors： Calo' G,Guerrini R,Rizzi A,Salvadori S,Regoli D

更新日期：2000-04-01 00:00:00

abstract：:1. Many apparent actions of adenosine 5'-triphosphate (ATP) are mediated by adenosine produced by enzymatic hydrolysis of the nucleotide. Previously described actions of ATP in the CNS have been partly due to this phenomenon. In the present study analogues of ATP, which are not hydrolysed to adenosine, were used to se...

journal_title：British journal of pharmacology

authors： Stone TW,Cusack NJ

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cigarette smoke is a major cause for chronic obstructive pulmonary disease (COPD). Andrographolide is an active biomolecule isolated from the plant Andrographis paniculata. Andrographolide has been shown to activate nuclear factor erythroid-2-related factor 2 (Nrf2), a redox-sensitive antioxidant...

journal_title：British journal of pharmacology

authors： Guan SP,Tee W,Ng DS,Chan TK,Peh HY,Ho WE,Cheng C,Mak JC,Wong WS

更新日期：2013-04-01 00:00:00

abstract：:Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of ac...

journal_title：British journal of pharmacology

authors： Roche D,Gil D,Giraldo J

更新日期：2013-07-01 00:00:00

abstract：:1. Modulations of Cl- responses to glycine by 5-hydroxytryptamine ligands were studied in cultured spinal neurones, by the whole-cell recording technique. 2. Three 5-HT3 antagonists were found to potentiate reversibly responses to low concentrations of glycine. Potentiations were induced by micromolar concentrations o...

journal_title：British journal of pharmacology

authors： Chesnoy-Marchais D

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N-type voltage-gated calcium (Cav 2.2) channels are critical determinants of increased neuronal excitability and neurotransmission accompanying persistent neuropathic pain. Although Cav 2.2 channel antagonists are recommended as first-line treatment for neuropathic pain, calcium-current blocking ...

journal_title：British journal of pharmacology

authors： Moutal A,Li W,Wang Y,Ju W,Luo S,Cai S,François-Moutal L,Perez-Miller S,Hu J,Dustrude ET,Vanderah TW,Gokhale V,Khanna M,Khanna R

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intestinal mucositis is a common side-effect of irinotecan-based cancer chemotherapy regimens. This mucositis is associated with cytokine activation and NO synthesis. Production of IL-18 is up-regulated in patients suffering from inflammatory bowel disease. Therefore, we have investigated the rol...

journal_title：British journal of pharmacology

authors： Lima-Júnior RC,Freitas HC,Wong DV,Wanderley CW,Nunes LG,Leite LL,Miranda SP,Souza MH,Brito GA,Magalhães PJ,Teixeira MM,Cunha FQ,Ribeiro RA

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Subset of macrophages within the atheroma plaque displays a high glucose uptake activity. Nevertheless, the molecular mechanisms and the pathophysiological significance of this high glucose need remain unclear. While the role for hypoxia and hypoxia inducible factor 1α has been demonstrated, the ...

journal_title：British journal of pharmacology

authors： Ménégaut L,Jalil A,Pilot T,van Dongen K,Crespy V,Steinmetz E,Pais de Barros JP,Geissler A,Le Goff W,Venteclef N,Lagrost L,Gautier T,Thomas C,Masson D

更新日期：2020-12-29 00:00:00

abstract：:1. The fall in arterial blood pressure with bradycardia that occurs on injection of clonidine into the cerebral ventricles and into the cisterna magna is attributed to an action on ;chemosensitive zones' situated at the ventral surface of the brain stem. This conclusion is based on the following results obtained in ca...

journal_title：British journal of pharmacology

authors： Bousquet P,Guertzenstein PG

更新日期：1973-12-01 00:00:00

abstract：:1. The effects of dopamine on the L-type Ca2+ current (ICa,L) of both atrial and ventricular single myocytes and on the force of contraction of atrial trabeculae in rat heart were investigated. 2. Dopamine increased atrial ICa,L at concentrations higher than 1 microM, but had little or no effect on ICa,L at lower conc...

journal_title：British journal of pharmacology

authors： Zhao H,Matsuoka S,Fujioka Y,Noma A

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Palmitoylethanolamide (PEA) is an endogenous congener of anandamide and potentiates its actions at cannabinoid CB1 and CB2 receptors, and at transient receptor potential vanilloid type-1 (TRPV1) channels. The other endocannabinoid, 2-arachidonoylglycerol (2-AG), was recently suggested to act as a...

journal_title：British journal of pharmacology

authors： Petrosino S,Schiano Moriello A,Cerrato S,Fusco M,Puigdemont A,De Petrocellis L,Di Marzo V

更新日期：2016-04-01 00:00:00

abstract：:1. The effects of (-)-isoprenaline and the new beta-adrenoceptor agonist, MJ-9184-1, on the lungs, on the cardiovascular system, and on slow contracting skeletal muscle have been compared in cats under chloralose anaesthesia.2. Both amines reduced the increases in airways resistance produced by 5-HT, depressed incompl...

journal_title：British journal of pharmacology

authors： Gwee MC,Nott MW,Raper C,Rodger IW

更新日期：1972-11-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) is a relatively recently discovered molecule originating in the so-called L-cells of the intestine. The peptide has insulinotrophic properties and it is this characteristic that has predominantly been investigated. This has led to the use of the GLP-1-like peptide exendin-4 (EX-4), whic...

journal_title：British journal of pharmacology

authors： Harkavyi A,Whitton PS

更新日期：2010-02-01 00:00:00

abstract：:1. The effects of chronic oral administration of desmethylimipramine (DMI) or zimelidine (1.25 and 5 mg kg-1 twice daily for 21 days) were studied on rat whole cortical gamma-aminobutyric acidB (GABAB) binding sites. No changes in receptor affinity or number were found with either drug. 2. A subsequent study of GABAB ...

journal_title：British journal of pharmacology

authors： Cross JA,Horton RW

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transforming growth factor beta1 (TGFbeta1) is generated in atherosclerotic and injured vessel walls. We examined whether the endothelial-to-mesenchymal transdifferentiation induced by TGFbeta1 affects endothelial functions. EXPERIMENTAL APPROACH:Bovine aortic endothelial cells (BAECs) were trea...

journal_title：British journal of pharmacology

authors： Watanabe M,Oike M,Ohta Y,Nawata H,Ito Y

更新日期：2006-10-01 00:00:00

abstract：:1. Partial agonists of the beta2-adrenoceptor which activate adenylyl cyclase are widely used as bronchodilators for the relief of bronchoconstriction accompanying many disease conditions, including bronchial asthma. The bronchodilator salmeterol has both a prolonged duration of action in bronchial tissue and the abil...

journal_title：British journal of pharmacology

authors： January B,Seibold A,Allal C,Whaley BS,Knoll BJ,Moore RH,Dickey BF,Barber R,Clark RB

更新日期：1998-02-01 00:00:00